Predictors and prevention of diabetic cardiomyopathy

Vishalakshi Chavali, Suresh C Tyagi, Paras K Mishra Department of Physiology and Biophysics, School of Medicine, University of Louisville, Louisville, Kentucky, USA Abstract: Despite our cognizance that diabetes can enhance the chances of heart failure, causes multiorgan failure,and contributes to m...

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Autores principales:	Chavali V, Tyagi SC, Mishra PK
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/b87b468161fb4e5a87e2cfce9f6724fd
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spelling	oai:doaj.org-article:b87b468161fb4e5a87e2cfce9f6724fd2021-12-02T05:51:42ZPredictors and prevention of diabetic cardiomyopathy1178-7007https://doaj.org/article/b87b468161fb4e5a87e2cfce9f6724fd2013-04-01T00:00:00Zhttp://www.dovepress.com/predictors-and-prevention-of-diabetic-cardiomyopathy-a12722https://doaj.org/toc/1178-7007Vishalakshi Chavali, Suresh C Tyagi, Paras K Mishra Department of Physiology and Biophysics, School of Medicine, University of Louisville, Louisville, Kentucky, USA Abstract: Despite our cognizance that diabetes can enhance the chances of heart failure, causes multiorgan failure,and contributes to morbidity and mortality, it is rapidly increasing menace worldwide. Less attention has been paid to alert prediabetics through determining the comprehensive predictors of diabetic cardiomyopathy (DCM) and ameliorating DCM using novel approaches. DCM is recognized as asymptomatic progressing structural and functional remodeling in the heart of diabetics, in the absence of coronary atherosclerosis and hypertension. The three major stages of DCM are: (1) early stage, where cellular and metabolic changes occur without obvious systolic dysfunction; (2) middle stage, which is characterized by increased apoptosis, a slight increase in left ventricular size, and diastolic dysfunction and where ejection fraction (EF) is <50%; and (3) late stage, which is characterized by alteration in microvasculature compliance, an increase in left ventricular size, and a decrease in cardiac performance leading to heart failure. Recent investigations have revealed that DCM is multifactorial in nature and cellular, molecular, and metabolic perturbations predisposed and contributed to DCM. Differential expression of microRNA (miRNA), signaling molecules involved in glucose metabolism, hyperlipidemia, advanced glycogen end products, cardiac extracellular matrix remodeling, and alteration in survival and differentiation of resident cardiac stem cells are manifested in DCM. A sedentary lifestyle and high fat diet causes obesity and this leads to type 2 diabetes and DCM. However, exercise training improves insulin sensitivity, contractility of cardiomyocytes, and cardiac performance in type 2 diabetes. These findings provide new clues to diagnose and mitigate DCM. This review embodies developments in the field of DCM with the aim of elucidating the future perspectives of predictors and prevention of DCM. Keywords: diabetes, obesity, exercise, heart failure, miRNA, oxidative stressChavali VTyagi SCMishra PKDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2013, Iss default, Pp 151-160 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Chavali V Tyagi SC Mishra PK Predictors and prevention of diabetic cardiomyopathy
description	Vishalakshi Chavali, Suresh C Tyagi, Paras K Mishra Department of Physiology and Biophysics, School of Medicine, University of Louisville, Louisville, Kentucky, USA Abstract: Despite our cognizance that diabetes can enhance the chances of heart failure, causes multiorgan failure,and contributes to morbidity and mortality, it is rapidly increasing menace worldwide. Less attention has been paid to alert prediabetics through determining the comprehensive predictors of diabetic cardiomyopathy (DCM) and ameliorating DCM using novel approaches. DCM is recognized as asymptomatic progressing structural and functional remodeling in the heart of diabetics, in the absence of coronary atherosclerosis and hypertension. The three major stages of DCM are: (1) early stage, where cellular and metabolic changes occur without obvious systolic dysfunction; (2) middle stage, which is characterized by increased apoptosis, a slight increase in left ventricular size, and diastolic dysfunction and where ejection fraction (EF) is <50%; and (3) late stage, which is characterized by alteration in microvasculature compliance, an increase in left ventricular size, and a decrease in cardiac performance leading to heart failure. Recent investigations have revealed that DCM is multifactorial in nature and cellular, molecular, and metabolic perturbations predisposed and contributed to DCM. Differential expression of microRNA (miRNA), signaling molecules involved in glucose metabolism, hyperlipidemia, advanced glycogen end products, cardiac extracellular matrix remodeling, and alteration in survival and differentiation of resident cardiac stem cells are manifested in DCM. A sedentary lifestyle and high fat diet causes obesity and this leads to type 2 diabetes and DCM. However, exercise training improves insulin sensitivity, contractility of cardiomyocytes, and cardiac performance in type 2 diabetes. These findings provide new clues to diagnose and mitigate DCM. This review embodies developments in the field of DCM with the aim of elucidating the future perspectives of predictors and prevention of DCM. Keywords: diabetes, obesity, exercise, heart failure, miRNA, oxidative stress
format	article
author	Chavali V Tyagi SC Mishra PK
author_facet	Chavali V Tyagi SC Mishra PK
author_sort	Chavali V
title	Predictors and prevention of diabetic cardiomyopathy
title_short	Predictors and prevention of diabetic cardiomyopathy
title_full	Predictors and prevention of diabetic cardiomyopathy
title_fullStr	Predictors and prevention of diabetic cardiomyopathy
title_full_unstemmed	Predictors and prevention of diabetic cardiomyopathy
title_sort	predictors and prevention of diabetic cardiomyopathy
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/b87b468161fb4e5a87e2cfce9f6724fd
work_keys_str_mv	AT chavaliv predictorsandpreventionofdiabeticcardiomyopathy AT tyagisc predictorsandpreventionofdiabeticcardiomyopathy AT mishrapk predictorsandpreventionofdiabeticcardiomyopathy
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Predictors and prevention of diabetic cardiomyopathy

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