Time-Resolved Visual Chiral Discrimination of Cysteine Using Unmodified CdTe Quantum Dots

Abstract Herein, we demonstrate a simple yet novel luminescence assay for visual chiral discrimination of cysteine. Thioglycolic acid (TGA)-capped cadmium-telluride (CdTe) quantum dots (QDs) exposing green emission were directly synthesized in aqueous solution. The interaction between cysteine molec...

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Autores principales:	Forough Ghasemi, M. Reza Hormozi-Nezhad, Morteza Mahmoudi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b87cba5dbd884058a04b83a3bb1554b9
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spelling	oai:doaj.org-article:b87cba5dbd884058a04b83a3bb1554b92021-12-02T15:06:28ZTime-Resolved Visual Chiral Discrimination of Cysteine Using Unmodified CdTe Quantum Dots10.1038/s41598-017-00983-22045-2322https://doaj.org/article/b87cba5dbd884058a04b83a3bb1554b92017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00983-2https://doaj.org/toc/2045-2322Abstract Herein, we demonstrate a simple yet novel luminescence assay for visual chiral discrimination of cysteine. Thioglycolic acid (TGA)-capped cadmium-telluride (CdTe) quantum dots (QDs) exposing green emission were directly synthesized in aqueous solution. The interaction between cysteine molecules and CdTe QDs induced the aggregation of QDs via hydrogen bonding. As a result of electronic coupling within these aggregates, a redshift both in the absorption and emission spectra of QDs occured. The difference in the kinetics of the interactions between L- and D-cysteine with CdTe QDs led to chiral recognition of these enantiomers. Addition of D-cysteine to CdTe QDs in a basic media caused a green-to-yellow color change, while no color alteration in QDs emission was observed in the presence of L-cysteine after 2 hours. Notably, the QDs used in the proposed assay are free from any labling/modification, which makes the present strategy highly attractive for sensing applications. Furthermore, the presented chiral assay is able to determine the enantiomeric excess (ee) of D-cysteine in the whole range of ee values (from −100% to 100%).Forough GhasemiM. Reza Hormozi-NezhadMorteza MahmoudiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Forough Ghasemi M. Reza Hormozi-Nezhad Morteza Mahmoudi Time-Resolved Visual Chiral Discrimination of Cysteine Using Unmodified CdTe Quantum Dots
description	Abstract Herein, we demonstrate a simple yet novel luminescence assay for visual chiral discrimination of cysteine. Thioglycolic acid (TGA)-capped cadmium-telluride (CdTe) quantum dots (QDs) exposing green emission were directly synthesized in aqueous solution. The interaction between cysteine molecules and CdTe QDs induced the aggregation of QDs via hydrogen bonding. As a result of electronic coupling within these aggregates, a redshift both in the absorption and emission spectra of QDs occured. The difference in the kinetics of the interactions between L- and D-cysteine with CdTe QDs led to chiral recognition of these enantiomers. Addition of D-cysteine to CdTe QDs in a basic media caused a green-to-yellow color change, while no color alteration in QDs emission was observed in the presence of L-cysteine after 2 hours. Notably, the QDs used in the proposed assay are free from any labling/modification, which makes the present strategy highly attractive for sensing applications. Furthermore, the presented chiral assay is able to determine the enantiomeric excess (ee) of D-cysteine in the whole range of ee values (from −100% to 100%).
format	article
author	Forough Ghasemi M. Reza Hormozi-Nezhad Morteza Mahmoudi
author_facet	Forough Ghasemi M. Reza Hormozi-Nezhad Morteza Mahmoudi
author_sort	Forough Ghasemi
title	Time-Resolved Visual Chiral Discrimination of Cysteine Using Unmodified CdTe Quantum Dots
title_short	Time-Resolved Visual Chiral Discrimination of Cysteine Using Unmodified CdTe Quantum Dots
title_full	Time-Resolved Visual Chiral Discrimination of Cysteine Using Unmodified CdTe Quantum Dots
title_fullStr	Time-Resolved Visual Chiral Discrimination of Cysteine Using Unmodified CdTe Quantum Dots
title_full_unstemmed	Time-Resolved Visual Chiral Discrimination of Cysteine Using Unmodified CdTe Quantum Dots
title_sort	time-resolved visual chiral discrimination of cysteine using unmodified cdte quantum dots
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b87cba5dbd884058a04b83a3bb1554b9
work_keys_str_mv	AT foroughghasemi timeresolvedvisualchiraldiscriminationofcysteineusingunmodifiedcdtequantumdots AT mrezahormozinezhad timeresolvedvisualchiraldiscriminationofcysteineusingunmodifiedcdtequantumdots AT mortezamahmoudi timeresolvedvisualchiraldiscriminationofcysteineusingunmodifiedcdtequantumdots
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Time-Resolved Visual Chiral Discrimination of Cysteine Using Unmodified CdTe Quantum Dots

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