Time-Resolved Visual Chiral Discrimination of Cysteine Using Unmodified CdTe Quantum Dots

Abstract Herein, we demonstrate a simple yet novel luminescence assay for visual chiral discrimination of cysteine. Thioglycolic acid (TGA)-capped cadmium-telluride (CdTe) quantum dots (QDs) exposing green emission were directly synthesized in aqueous solution. The interaction between cysteine molec...

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Auteurs principaux: Forough Ghasemi, M. Reza Hormozi-Nezhad, Morteza Mahmoudi
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Langue:EN
Publié: Nature Portfolio 2017
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spelling oai:doaj.org-article:b87cba5dbd884058a04b83a3bb1554b92021-12-02T15:06:28ZTime-Resolved Visual Chiral Discrimination of Cysteine Using Unmodified CdTe Quantum Dots10.1038/s41598-017-00983-22045-2322https://doaj.org/article/b87cba5dbd884058a04b83a3bb1554b92017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00983-2https://doaj.org/toc/2045-2322Abstract Herein, we demonstrate a simple yet novel luminescence assay for visual chiral discrimination of cysteine. Thioglycolic acid (TGA)-capped cadmium-telluride (CdTe) quantum dots (QDs) exposing green emission were directly synthesized in aqueous solution. The interaction between cysteine molecules and CdTe QDs induced the aggregation of QDs via hydrogen bonding. As a result of electronic coupling within these aggregates, a redshift both in the absorption and emission spectra of QDs occured. The difference in the kinetics of the interactions between L- and D-cysteine with CdTe QDs led to chiral recognition of these enantiomers. Addition of D-cysteine to CdTe QDs in a basic media caused a green-to-yellow color change, while no color alteration in QDs emission was observed in the presence of L-cysteine after 2 hours. Notably, the QDs used in the proposed assay are free from any labling/modification, which makes the present strategy highly attractive for sensing applications. Furthermore, the presented chiral assay is able to determine the enantiomeric excess (ee) of D-cysteine in the whole range of ee values (from −100% to 100%).Forough GhasemiM. Reza Hormozi-NezhadMorteza MahmoudiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Forough Ghasemi
M. Reza Hormozi-Nezhad
Morteza Mahmoudi
Time-Resolved Visual Chiral Discrimination of Cysteine Using Unmodified CdTe Quantum Dots
description Abstract Herein, we demonstrate a simple yet novel luminescence assay for visual chiral discrimination of cysteine. Thioglycolic acid (TGA)-capped cadmium-telluride (CdTe) quantum dots (QDs) exposing green emission were directly synthesized in aqueous solution. The interaction between cysteine molecules and CdTe QDs induced the aggregation of QDs via hydrogen bonding. As a result of electronic coupling within these aggregates, a redshift both in the absorption and emission spectra of QDs occured. The difference in the kinetics of the interactions between L- and D-cysteine with CdTe QDs led to chiral recognition of these enantiomers. Addition of D-cysteine to CdTe QDs in a basic media caused a green-to-yellow color change, while no color alteration in QDs emission was observed in the presence of L-cysteine after 2 hours. Notably, the QDs used in the proposed assay are free from any labling/modification, which makes the present strategy highly attractive for sensing applications. Furthermore, the presented chiral assay is able to determine the enantiomeric excess (ee) of D-cysteine in the whole range of ee values (from −100% to 100%).
format article
author Forough Ghasemi
M. Reza Hormozi-Nezhad
Morteza Mahmoudi
author_facet Forough Ghasemi
M. Reza Hormozi-Nezhad
Morteza Mahmoudi
author_sort Forough Ghasemi
title Time-Resolved Visual Chiral Discrimination of Cysteine Using Unmodified CdTe Quantum Dots
title_short Time-Resolved Visual Chiral Discrimination of Cysteine Using Unmodified CdTe Quantum Dots
title_full Time-Resolved Visual Chiral Discrimination of Cysteine Using Unmodified CdTe Quantum Dots
title_fullStr Time-Resolved Visual Chiral Discrimination of Cysteine Using Unmodified CdTe Quantum Dots
title_full_unstemmed Time-Resolved Visual Chiral Discrimination of Cysteine Using Unmodified CdTe Quantum Dots
title_sort time-resolved visual chiral discrimination of cysteine using unmodified cdte quantum dots
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/b87cba5dbd884058a04b83a3bb1554b9
work_keys_str_mv AT foroughghasemi timeresolvedvisualchiraldiscriminationofcysteineusingunmodifiedcdtequantumdots
AT mrezahormozinezhad timeresolvedvisualchiraldiscriminationofcysteineusingunmodifiedcdtequantumdots
AT mortezamahmoudi timeresolvedvisualchiraldiscriminationofcysteineusingunmodifiedcdtequantumdots
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