Cardiac radiotherapy induces electrical conduction reprogramming in the absence of transmural fibrosis

Noninvasive cardiac radiotherapy may effectively manage ventricular tachycardia in refractory patients, but its radiobiologic mechanisms of action are unclear. Here, the authors show that photon radiation durably and favourably reprograms cardiac conduction in the absence of transmural fibrosis sugg...

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Autores principales:	David M. Zhang, Rachita Navara, Tiankai Yin, Jeffrey Szymanski, Uri Goldsztejn, Camryn Kenkel, Adam Lang, Cedric Mpoy, Catherine E. Lipovsky, Yun Qiao, Stephanie Hicks, Gang Li, Kaitlin M. S. Moore, Carmen Bergom, Buck E. Rogers, Clifford G. Robinson, Phillip S. Cuculich, Julie K. Schwarz, Stacey L. Rentschler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b87d769fbd7248d484a32dad47327e5a
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spelling	oai:doaj.org-article:b87d769fbd7248d484a32dad47327e5a2021-12-02T15:14:56ZCardiac radiotherapy induces electrical conduction reprogramming in the absence of transmural fibrosis10.1038/s41467-021-25730-02041-1723https://doaj.org/article/b87d769fbd7248d484a32dad47327e5a2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25730-0https://doaj.org/toc/2041-1723Noninvasive cardiac radiotherapy may effectively manage ventricular tachycardia in refractory patients, but its radiobiologic mechanisms of action are unclear. Here, the authors show that photon radiation durably and favourably reprograms cardiac conduction in the absence of transmural fibrosis suggesting this could be the mechanism through which cardiac radiotherapy to modulates arrhythmia susceptibility.David M. ZhangRachita NavaraTiankai YinJeffrey SzymanskiUri GoldsztejnCamryn KenkelAdam LangCedric MpoyCatherine E. LipovskyYun QiaoStephanie HicksGang LiKaitlin M. S. MooreCarmen BergomBuck E. RogersClifford G. RobinsonPhillip S. CuculichJulie K. SchwarzStacey L. RentschlerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David M. Zhang Rachita Navara Tiankai Yin Jeffrey Szymanski Uri Goldsztejn Camryn Kenkel Adam Lang Cedric Mpoy Catherine E. Lipovsky Yun Qiao Stephanie Hicks Gang Li Kaitlin M. S. Moore Carmen Bergom Buck E. Rogers Clifford G. Robinson Phillip S. Cuculich Julie K. Schwarz Stacey L. Rentschler Cardiac radiotherapy induces electrical conduction reprogramming in the absence of transmural fibrosis
description	Noninvasive cardiac radiotherapy may effectively manage ventricular tachycardia in refractory patients, but its radiobiologic mechanisms of action are unclear. Here, the authors show that photon radiation durably and favourably reprograms cardiac conduction in the absence of transmural fibrosis suggesting this could be the mechanism through which cardiac radiotherapy to modulates arrhythmia susceptibility.
format	article
author	David M. Zhang Rachita Navara Tiankai Yin Jeffrey Szymanski Uri Goldsztejn Camryn Kenkel Adam Lang Cedric Mpoy Catherine E. Lipovsky Yun Qiao Stephanie Hicks Gang Li Kaitlin M. S. Moore Carmen Bergom Buck E. Rogers Clifford G. Robinson Phillip S. Cuculich Julie K. Schwarz Stacey L. Rentschler
author_facet	David M. Zhang Rachita Navara Tiankai Yin Jeffrey Szymanski Uri Goldsztejn Camryn Kenkel Adam Lang Cedric Mpoy Catherine E. Lipovsky Yun Qiao Stephanie Hicks Gang Li Kaitlin M. S. Moore Carmen Bergom Buck E. Rogers Clifford G. Robinson Phillip S. Cuculich Julie K. Schwarz Stacey L. Rentschler
author_sort	David M. Zhang
title	Cardiac radiotherapy induces electrical conduction reprogramming in the absence of transmural fibrosis
title_short	Cardiac radiotherapy induces electrical conduction reprogramming in the absence of transmural fibrosis
title_full	Cardiac radiotherapy induces electrical conduction reprogramming in the absence of transmural fibrosis
title_fullStr	Cardiac radiotherapy induces electrical conduction reprogramming in the absence of transmural fibrosis
title_full_unstemmed	Cardiac radiotherapy induces electrical conduction reprogramming in the absence of transmural fibrosis
title_sort	cardiac radiotherapy induces electrical conduction reprogramming in the absence of transmural fibrosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b87d769fbd7248d484a32dad47327e5a
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Cardiac radiotherapy induces electrical conduction reprogramming in the absence of transmural fibrosis

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