A Meta-Analysis of Growth Differentiation Factor-15 and Prognosis in Chronic Heart Failure

Background: Previous studies had reported increased circulating concentrations of growth differentiation factor-15 (GDF-15) in chronic heart failure (CHF), suggesting the potential prognostic significance of GDF-15 in this setting. To verify the relationship between the circulating GDF-15 levels and...

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Autores principales:	Jin-Wen Luo, Wen-Hui Duan, Lei Song, Yan-Qiao Yu, Da-Zhuo Shi
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	growth differentiation factor-15 chronic heart failure prognosis meta- analysis systematic review Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/b87eaf87957743ff907e87fb848295d7
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spelling	oai:doaj.org-article:b87eaf87957743ff907e87fb848295d72021-11-05T08:05:24ZA Meta-Analysis of Growth Differentiation Factor-15 and Prognosis in Chronic Heart Failure2297-055X10.3389/fcvm.2021.630818https://doaj.org/article/b87eaf87957743ff907e87fb848295d72021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.630818/fullhttps://doaj.org/toc/2297-055XBackground: Previous studies had reported increased circulating concentrations of growth differentiation factor-15 (GDF-15) in chronic heart failure (CHF), suggesting the potential prognostic significance of GDF-15 in this setting. To verify the relationship between the circulating GDF-15 levels and prognosis of CHF patients, we conducted an updated evidence-based meta-analysis.Methods: A comprehensive literature retrieval of PubMed, EMBASE, and Cochrane library was performed to collect the qualified studies that analyzed the prognostic value of GDF-15 in CHF from the inception of these online databases to September 25, 2021. The hazard ratio (HR) calculated for logGDF-15 of all-cause death and the related 95% confidence interval (CI) in multivariate analysis were used to measure the effect size. Additionally, subgroup analyses stratified by characteristics of the study participants were conducted for incremental evidence of GDF-15 in CHF with different clinical status.Results: A total of ten eligible studies involving 6,244 CHF patients were finally taken into the quantitative analysis. Results in the random-effects model indicated that there was an increased risk of 6% in all-cause mortality with a per 1LnU increase in baseline GDF-15 concentration (HR: 1.06, 95% CI: 1.03–1.10, P < 0.001). In stratified analyses, the association of GDF-15 with risk of all-cause mortality was found among chronic ischemic HF patients (HR:1.75, 95%CI: 1.24–2.48, P = 0.002), while the association was not found among chronic nonischemic HF patients (HR:1.01, 95%CI: 1.00–1.02, P = 0.219).Conclusion: The elevated GDF-15 is associated with an increased risk of all-cause mortality in CHF, especially, among CHF patients with ischemic etiology. The circulating GDF-15 might be a prognostic indicator in CHF patients.Registration Number:https://www.crd.york.ac.uk/PROSPERO; CRD42020210796.Jin-Wen LuoWen-Hui DuanLei SongYan-Qiao YuDa-Zhuo ShiFrontiers Media S.A.articlegrowth differentiation factor-15chronic heart failureprognosismeta- analysissystematic reviewDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	growth differentiation factor-15 chronic heart failure prognosis meta- analysis systematic review Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	growth differentiation factor-15 chronic heart failure prognosis meta- analysis systematic review Diseases of the circulatory (Cardiovascular) system RC666-701 Jin-Wen Luo Wen-Hui Duan Lei Song Yan-Qiao Yu Da-Zhuo Shi A Meta-Analysis of Growth Differentiation Factor-15 and Prognosis in Chronic Heart Failure
description	Background: Previous studies had reported increased circulating concentrations of growth differentiation factor-15 (GDF-15) in chronic heart failure (CHF), suggesting the potential prognostic significance of GDF-15 in this setting. To verify the relationship between the circulating GDF-15 levels and prognosis of CHF patients, we conducted an updated evidence-based meta-analysis.Methods: A comprehensive literature retrieval of PubMed, EMBASE, and Cochrane library was performed to collect the qualified studies that analyzed the prognostic value of GDF-15 in CHF from the inception of these online databases to September 25, 2021. The hazard ratio (HR) calculated for logGDF-15 of all-cause death and the related 95% confidence interval (CI) in multivariate analysis were used to measure the effect size. Additionally, subgroup analyses stratified by characteristics of the study participants were conducted for incremental evidence of GDF-15 in CHF with different clinical status.Results: A total of ten eligible studies involving 6,244 CHF patients were finally taken into the quantitative analysis. Results in the random-effects model indicated that there was an increased risk of 6% in all-cause mortality with a per 1LnU increase in baseline GDF-15 concentration (HR: 1.06, 95% CI: 1.03–1.10, P < 0.001). In stratified analyses, the association of GDF-15 with risk of all-cause mortality was found among chronic ischemic HF patients (HR:1.75, 95%CI: 1.24–2.48, P = 0.002), while the association was not found among chronic nonischemic HF patients (HR:1.01, 95%CI: 1.00–1.02, P = 0.219).Conclusion: The elevated GDF-15 is associated with an increased risk of all-cause mortality in CHF, especially, among CHF patients with ischemic etiology. The circulating GDF-15 might be a prognostic indicator in CHF patients.Registration Number:https://www.crd.york.ac.uk/PROSPERO; CRD42020210796.
format	article
author	Jin-Wen Luo Wen-Hui Duan Lei Song Yan-Qiao Yu Da-Zhuo Shi
author_facet	Jin-Wen Luo Wen-Hui Duan Lei Song Yan-Qiao Yu Da-Zhuo Shi
author_sort	Jin-Wen Luo
title	A Meta-Analysis of Growth Differentiation Factor-15 and Prognosis in Chronic Heart Failure
title_short	A Meta-Analysis of Growth Differentiation Factor-15 and Prognosis in Chronic Heart Failure
title_full	A Meta-Analysis of Growth Differentiation Factor-15 and Prognosis in Chronic Heart Failure
title_fullStr	A Meta-Analysis of Growth Differentiation Factor-15 and Prognosis in Chronic Heart Failure
title_full_unstemmed	A Meta-Analysis of Growth Differentiation Factor-15 and Prognosis in Chronic Heart Failure
title_sort	meta-analysis of growth differentiation factor-15 and prognosis in chronic heart failure
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b87eaf87957743ff907e87fb848295d7
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A Meta-Analysis of Growth Differentiation Factor-15 and Prognosis in Chronic Heart Failure

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