The C. difficile toxin B membrane translocation machinery is an evolutionarily conserved protein delivery apparatus

Large Clostridial toxins infiltrate host cells using a translocation domain (LCT-T). Here, using a genomics-driven approach and functional assays, the authors uncover the presence of distant LCT-T homologs in bacteria outside clostridia and provide evidence for a toxic effector function in the gamma...

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Autores principales:	Kathleen E. Orrell, Michael J. Mansfield, Andrew C. Doxey, Roman A. Melnyk
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b882a90d75044ebbb51ee0106300e943
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spelling	oai:doaj.org-article:b882a90d75044ebbb51ee0106300e9432021-12-02T17:32:57ZThe C. difficile toxin B membrane translocation machinery is an evolutionarily conserved protein delivery apparatus10.1038/s41467-020-14306-z2041-1723https://doaj.org/article/b882a90d75044ebbb51ee0106300e9432020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14306-zhttps://doaj.org/toc/2041-1723Large Clostridial toxins infiltrate host cells using a translocation domain (LCT-T). Here, using a genomics-driven approach and functional assays, the authors uncover the presence of distant LCT-T homologs in bacteria outside clostridia and provide evidence for a toxic effector function in the gammaproteobacterium Serratia marcescens.Kathleen E. OrrellMichael J. MansfieldAndrew C. DoxeyRoman A. MelnykNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kathleen E. Orrell Michael J. Mansfield Andrew C. Doxey Roman A. Melnyk The C. difficile toxin B membrane translocation machinery is an evolutionarily conserved protein delivery apparatus
description	Large Clostridial toxins infiltrate host cells using a translocation domain (LCT-T). Here, using a genomics-driven approach and functional assays, the authors uncover the presence of distant LCT-T homologs in bacteria outside clostridia and provide evidence for a toxic effector function in the gammaproteobacterium Serratia marcescens.
format	article
author	Kathleen E. Orrell Michael J. Mansfield Andrew C. Doxey Roman A. Melnyk
author_facet	Kathleen E. Orrell Michael J. Mansfield Andrew C. Doxey Roman A. Melnyk
author_sort	Kathleen E. Orrell
title	The C. difficile toxin B membrane translocation machinery is an evolutionarily conserved protein delivery apparatus
title_short	The C. difficile toxin B membrane translocation machinery is an evolutionarily conserved protein delivery apparatus
title_full	The C. difficile toxin B membrane translocation machinery is an evolutionarily conserved protein delivery apparatus
title_fullStr	The C. difficile toxin B membrane translocation machinery is an evolutionarily conserved protein delivery apparatus
title_full_unstemmed	The C. difficile toxin B membrane translocation machinery is an evolutionarily conserved protein delivery apparatus
title_sort	c. difficile toxin b membrane translocation machinery is an evolutionarily conserved protein delivery apparatus
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b882a90d75044ebbb51ee0106300e943
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The C. difficile toxin B membrane translocation machinery is an evolutionarily conserved protein delivery apparatus

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