Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function
Pulmonary function is influenced by environmental factors, lifestyle, and genetics. Here, in a multiethnic GWAS meta-analysis for pulmonary function traits, the authors identify over 50 additional genetic loci, a subset of which are specific for European, African, Asian, or Hispanic/Latino ancestry.
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Nature Portfolio
2018
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oai:doaj.org-article:b883c3b4b1074a7eaf40eb62c002409c2021-12-02T16:56:43ZMultiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function10.1038/s41467-018-05369-02041-1723https://doaj.org/article/b883c3b4b1074a7eaf40eb62c002409c2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05369-0https://doaj.org/toc/2041-1723Pulmonary function is influenced by environmental factors, lifestyle, and genetics. Here, in a multiethnic GWAS meta-analysis for pulmonary function traits, the authors identify over 50 additional genetic loci, a subset of which are specific for European, African, Asian, or Hispanic/Latino ancestry.Annah B. WyssTamar SoferMi Kyeong LeeNatalie TerzikhanJennifer N. NguyenLies LahousseJeanne C. LatourelleAlbert Vernon SmithTraci M. BartzMary F. FeitosaWei GaoTarunveer S. AhluwaliaWenbo TangChristopher OldmeadowQing DuanKim de JongMary K. WojczynskiXin-Qun WangRaymond NoordamFernando Pires HartwigVictoria E. JacksonTianyuan WangMa’en ObeidatBrian D. HobbsTianxiao HuanHongsheng GuiMargaret M. ParkerDonglei HuLauren S. MogilGleb KichaevJianping JinMariaelisa GraffTamara B. HarrisRavi KalhanSusan R. HeckbertLavinia PaternosterKristin M. BurkartYongmei LiuElizabeth G. HollidayJames G. WilsonJudith M. VonkJason L. SandersR. Graham BarrRenée de MutsertAna Maria Baptista MenezesHieab H. H. AdamsMaarten van den BergeRoby JoehanesAlbert M. LevinJennifer LibertoLenore J. LaunerAlanna C. MorrisonColleen M. SitlaniJuan C. CeledónStephen B. KritchevskyRodney J. ScottKaare ChristensenJerome I. RotterTobias N. BontenFernando César WehrmeisterYohan BosséShujie XiaoSam OhNora FranceschiniJennifer A. BrodyRobert C. KaplanKurt LohmanMark McEvoyMichael A. ProvinceFrits R. RosendaalKent D. TaylorDavid C. NickleL. Keoki WilliamsEsteban G. BurchardHeather E. WheelerDon D. SinVilmundur GudnasonKari E. NorthMyriam FornageBruce M. PsatyRichard H. MyersGeorge O’ConnorTorben HansenCathy C. LauriePatricia A. CassanoJoohon SungWoo Jin KimJohn R. AttiaLeslie LangeH. Marike BoezenBharat ThyagarajanStephen S. RichDennis O. Mook-KanamoriBernardo Lessa HortaAndré G. UitterlindenHae Kyung ImMichael H. ChoGuy G. BrusselleSina A. GharibJosée DupuisAni ManichaikulStephanie J. LondonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Annah B. Wyss Tamar Sofer Mi Kyeong Lee Natalie Terzikhan Jennifer N. Nguyen Lies Lahousse Jeanne C. Latourelle Albert Vernon Smith Traci M. Bartz Mary F. Feitosa Wei Gao Tarunveer S. Ahluwalia Wenbo Tang Christopher Oldmeadow Qing Duan Kim de Jong Mary K. Wojczynski Xin-Qun Wang Raymond Noordam Fernando Pires Hartwig Victoria E. Jackson Tianyuan Wang Ma’en Obeidat Brian D. Hobbs Tianxiao Huan Hongsheng Gui Margaret M. Parker Donglei Hu Lauren S. Mogil Gleb Kichaev Jianping Jin Mariaelisa Graff Tamara B. Harris Ravi Kalhan Susan R. Heckbert Lavinia Paternoster Kristin M. Burkart Yongmei Liu Elizabeth G. Holliday James G. Wilson Judith M. Vonk Jason L. Sanders R. Graham Barr Renée de Mutsert Ana Maria Baptista Menezes Hieab H. H. Adams Maarten van den Berge Roby Joehanes Albert M. Levin Jennifer Liberto Lenore J. Launer Alanna C. Morrison Colleen M. Sitlani Juan C. Celedón Stephen B. Kritchevsky Rodney J. Scott Kaare Christensen Jerome I. Rotter Tobias N. Bonten Fernando César Wehrmeister Yohan Bossé Shujie Xiao Sam Oh Nora Franceschini Jennifer A. Brody Robert C. Kaplan Kurt Lohman Mark McEvoy Michael A. Province Frits R. Rosendaal Kent D. Taylor David C. Nickle L. Keoki Williams Esteban G. Burchard Heather E. Wheeler Don D. Sin Vilmundur Gudnason Kari E. North Myriam Fornage Bruce M. Psaty Richard H. Myers George O’Connor Torben Hansen Cathy C. Laurie Patricia A. Cassano Joohon Sung Woo Jin Kim John R. Attia Leslie Lange H. Marike Boezen Bharat Thyagarajan Stephen S. Rich Dennis O. Mook-Kanamori Bernardo Lessa Horta André G. Uitterlinden Hae Kyung Im Michael H. Cho Guy G. Brusselle Sina A. Gharib Josée Dupuis Ani Manichaikul Stephanie J. London Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function |
| description |
Pulmonary function is influenced by environmental factors, lifestyle, and genetics. Here, in a multiethnic GWAS meta-analysis for pulmonary function traits, the authors identify over 50 additional genetic loci, a subset of which are specific for European, African, Asian, or Hispanic/Latino ancestry. |
| format |
article |
| author |
Annah B. Wyss Tamar Sofer Mi Kyeong Lee Natalie Terzikhan Jennifer N. Nguyen Lies Lahousse Jeanne C. Latourelle Albert Vernon Smith Traci M. Bartz Mary F. Feitosa Wei Gao Tarunveer S. Ahluwalia Wenbo Tang Christopher Oldmeadow Qing Duan Kim de Jong Mary K. Wojczynski Xin-Qun Wang Raymond Noordam Fernando Pires Hartwig Victoria E. Jackson Tianyuan Wang Ma’en Obeidat Brian D. Hobbs Tianxiao Huan Hongsheng Gui Margaret M. Parker Donglei Hu Lauren S. Mogil Gleb Kichaev Jianping Jin Mariaelisa Graff Tamara B. Harris Ravi Kalhan Susan R. Heckbert Lavinia Paternoster Kristin M. Burkart Yongmei Liu Elizabeth G. Holliday James G. Wilson Judith M. Vonk Jason L. Sanders R. Graham Barr Renée de Mutsert Ana Maria Baptista Menezes Hieab H. H. Adams Maarten van den Berge Roby Joehanes Albert M. Levin Jennifer Liberto Lenore J. Launer Alanna C. Morrison Colleen M. Sitlani Juan C. Celedón Stephen B. Kritchevsky Rodney J. Scott Kaare Christensen Jerome I. Rotter Tobias N. Bonten Fernando César Wehrmeister Yohan Bossé Shujie Xiao Sam Oh Nora Franceschini Jennifer A. Brody Robert C. Kaplan Kurt Lohman Mark McEvoy Michael A. Province Frits R. Rosendaal Kent D. Taylor David C. Nickle L. Keoki Williams Esteban G. Burchard Heather E. Wheeler Don D. Sin Vilmundur Gudnason Kari E. North Myriam Fornage Bruce M. Psaty Richard H. Myers George O’Connor Torben Hansen Cathy C. Laurie Patricia A. Cassano Joohon Sung Woo Jin Kim John R. Attia Leslie Lange H. Marike Boezen Bharat Thyagarajan Stephen S. Rich Dennis O. Mook-Kanamori Bernardo Lessa Horta André G. Uitterlinden Hae Kyung Im Michael H. Cho Guy G. Brusselle Sina A. Gharib Josée Dupuis Ani Manichaikul Stephanie J. London |
| author_facet |
Annah B. Wyss Tamar Sofer Mi Kyeong Lee Natalie Terzikhan Jennifer N. Nguyen Lies Lahousse Jeanne C. Latourelle Albert Vernon Smith Traci M. Bartz Mary F. Feitosa Wei Gao Tarunveer S. Ahluwalia Wenbo Tang Christopher Oldmeadow Qing Duan Kim de Jong Mary K. Wojczynski Xin-Qun Wang Raymond Noordam Fernando Pires Hartwig Victoria E. Jackson Tianyuan Wang Ma’en Obeidat Brian D. Hobbs Tianxiao Huan Hongsheng Gui Margaret M. Parker Donglei Hu Lauren S. Mogil Gleb Kichaev Jianping Jin Mariaelisa Graff Tamara B. Harris Ravi Kalhan Susan R. Heckbert Lavinia Paternoster Kristin M. Burkart Yongmei Liu Elizabeth G. Holliday James G. Wilson Judith M. Vonk Jason L. Sanders R. Graham Barr Renée de Mutsert Ana Maria Baptista Menezes Hieab H. H. Adams Maarten van den Berge Roby Joehanes Albert M. Levin Jennifer Liberto Lenore J. Launer Alanna C. Morrison Colleen M. Sitlani Juan C. Celedón Stephen B. Kritchevsky Rodney J. Scott Kaare Christensen Jerome I. Rotter Tobias N. Bonten Fernando César Wehrmeister Yohan Bossé Shujie Xiao Sam Oh Nora Franceschini Jennifer A. Brody Robert C. Kaplan Kurt Lohman Mark McEvoy Michael A. Province Frits R. Rosendaal Kent D. Taylor David C. Nickle L. Keoki Williams Esteban G. Burchard Heather E. Wheeler Don D. Sin Vilmundur Gudnason Kari E. North Myriam Fornage Bruce M. Psaty Richard H. Myers George O’Connor Torben Hansen Cathy C. Laurie Patricia A. Cassano Joohon Sung Woo Jin Kim John R. Attia Leslie Lange H. Marike Boezen Bharat Thyagarajan Stephen S. Rich Dennis O. Mook-Kanamori Bernardo Lessa Horta André G. Uitterlinden Hae Kyung Im Michael H. Cho Guy G. Brusselle Sina A. Gharib Josée Dupuis Ani Manichaikul Stephanie J. London |
| author_sort |
Annah B. Wyss |
| title |
Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function |
| title_short |
Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function |
| title_full |
Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function |
| title_fullStr |
Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function |
| title_full_unstemmed |
Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function |
| title_sort |
multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/b883c3b4b1074a7eaf40eb62c002409c |
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