PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions

Group 2 innate lymphoid cells (ILC2s) are a component of type 2 immune response recently described to be involved in the regulation of anti-tumor immune responses. Here, the authors show that the expression of the peroxisome proliferator-activated receptor γ (PPAPγ) in human and mouse ILC2 sustains...

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Autores principales:	Giuseppe Ercolano, Alejandra Gomez-Cadena, Nina Dumauthioz, Giulia Vanoni, Mario Kreutzfeldt, Tania Wyss, Liliane Michalik, Romain Loyon, Angela Ianaro, Ping-Chih Ho, Christophe Borg, Manfred Kopf, Doron Merkler, Philippe Krebs, Pedro Romero, Sara Trabanelli, Camilla Jandus
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b884462c3efa444ba2a11976dff87142
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spelling	oai:doaj.org-article:b884462c3efa444ba2a11976dff871422021-12-02T15:38:20ZPPARɣ drives IL-33-dependent ILC2 pro-tumoral functions10.1038/s41467-021-22764-22041-1723https://doaj.org/article/b884462c3efa444ba2a11976dff871422021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22764-2https://doaj.org/toc/2041-1723Group 2 innate lymphoid cells (ILC2s) are a component of type 2 immune response recently described to be involved in the regulation of anti-tumor immune responses. Here, the authors show that the expression of the peroxisome proliferator-activated receptor γ (PPAPγ) in human and mouse ILC2 sustains type-2 cytokines secretion and support their pro-tumorigenic role in preclinical cancer models.Giuseppe ErcolanoAlejandra Gomez-CadenaNina DumauthiozGiulia VanoniMario KreutzfeldtTania WyssLiliane MichalikRomain LoyonAngela IanaroPing-Chih HoChristophe BorgManfred KopfDoron MerklerPhilippe KrebsPedro RomeroSara TrabanelliCamilla JandusNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Giuseppe Ercolano Alejandra Gomez-Cadena Nina Dumauthioz Giulia Vanoni Mario Kreutzfeldt Tania Wyss Liliane Michalik Romain Loyon Angela Ianaro Ping-Chih Ho Christophe Borg Manfred Kopf Doron Merkler Philippe Krebs Pedro Romero Sara Trabanelli Camilla Jandus PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions
description	Group 2 innate lymphoid cells (ILC2s) are a component of type 2 immune response recently described to be involved in the regulation of anti-tumor immune responses. Here, the authors show that the expression of the peroxisome proliferator-activated receptor γ (PPAPγ) in human and mouse ILC2 sustains type-2 cytokines secretion and support their pro-tumorigenic role in preclinical cancer models.
format	article
author	Giuseppe Ercolano Alejandra Gomez-Cadena Nina Dumauthioz Giulia Vanoni Mario Kreutzfeldt Tania Wyss Liliane Michalik Romain Loyon Angela Ianaro Ping-Chih Ho Christophe Borg Manfred Kopf Doron Merkler Philippe Krebs Pedro Romero Sara Trabanelli Camilla Jandus
author_facet	Giuseppe Ercolano Alejandra Gomez-Cadena Nina Dumauthioz Giulia Vanoni Mario Kreutzfeldt Tania Wyss Liliane Michalik Romain Loyon Angela Ianaro Ping-Chih Ho Christophe Borg Manfred Kopf Doron Merkler Philippe Krebs Pedro Romero Sara Trabanelli Camilla Jandus
author_sort	Giuseppe Ercolano
title	PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions
title_short	PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions
title_full	PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions
title_fullStr	PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions
title_full_unstemmed	PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions
title_sort	pparɣ drives il-33-dependent ilc2 pro-tumoral functions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b884462c3efa444ba2a11976dff87142
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PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions

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