Parechovirus neonatal sepsis and meningitis – a (still) poorly recognised agent

Human parechovirus (HPeV), a Picornaviridae virus, is a microorganism associated with respiratory and gastrointestinal infections, in most cases with a benign clinical course. However, some serotypes have been recently associated with a more serious clinical outcome in young children, namely sepsis-...

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Autores principales:	Raquel Garrido, Joana Antunes, Helena Pedroso, Madalena Fialho, Manuel Cunha
Formato:	article
Lenguaje:	EN IT
Publicado:	Hygeia Press di Corridori Marinella 2021
Materias:	fever without a source neonatal meningitis parechovirus newborn infant picornaviridae Medicine R Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/b8844f63e7f14446b993b7c5098e6227
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spelling	oai:doaj.org-article:b8844f63e7f14446b993b7c5098e62272021-11-30T17:55:51ZParechovirus neonatal sepsis and meningitis – a (still) poorly recognised agent2281-069210.7363/110102https://doaj.org/article/b8844f63e7f14446b993b7c5098e62272021-11-01T00:00:00Zhttps://jpnim.com/index.php/jpnim/article/view/1002https://doaj.org/toc/2281-0692Human parechovirus (HPeV), a Picornaviridae virus, is a microorganism associated with respiratory and gastrointestinal infections, in most cases with a benign clinical course. However, some serotypes have been recently associated with a more serious clinical outcome in young children, namely sepsis-like disease and meningitis. In this report, we describe the case of a previously healthy, 11-day-old infant in our Paediatric Emergency Department who presented with high fever, irritability and poor feeding. No other accompanying symptoms, such as respiratory, gastrointestinal or urinary, were shown by the patient. Family history unveiled an 18-month-old sibling with an upper respiratory tract infection. Physical examination was unremarkable. Laboratory testing revealed a normal total white cell count with lymphopenia and a maximum C-reactive protein value of 21.4 mg/L. Cerebrospinal fluid (CSF) analysis showed pleocytosis with high proteinorrachia and normal glycorrhachia. With the clinical suspicion of sepsis, she was hospitalized for clinical surveillance, and empirical antibiotics were administered. Although the bacteriological exams of blood and CSF were negative, RNA of an HPeV was detected in the CSF. She had a favourable clinical course, the cerebral ultrasound was normal, and the clinical follow-up showed adequate psychomotor development until today (18 months old). Recent publications suggested HPeV as one of the major agents of neonatal sepsis and meningitis. Similarly, several other studies reported significant neurological impairments in infants with HPeV infection. In line with these recent findings, we believe this clinical case further supports the need for more extensive research in viral aetiology and in particular of this, not so uncommon, agent in order to avoid unnecessary and potentially harmful interventions in newborns presenting with a sepsis-like clinical picture.Raquel GarridoJoana AntunesHelena PedrosoMadalena FialhoManuel CunhaHygeia Press di Corridori Marinellaarticlefever without a sourceneonatal meningitisparechovirusnewborninfantpicornaviridaeMedicineRPediatricsRJ1-570ENITJournal of Pediatric and Neonatal Individualized Medicine, Vol 11, Iss 1, Pp e110102-e110102 (2021)
institution	DOAJ
collection	DOAJ
language	EN IT
topic	fever without a source neonatal meningitis parechovirus newborn infant picornaviridae Medicine R Pediatrics RJ1-570
spellingShingle	fever without a source neonatal meningitis parechovirus newborn infant picornaviridae Medicine R Pediatrics RJ1-570 Raquel Garrido Joana Antunes Helena Pedroso Madalena Fialho Manuel Cunha Parechovirus neonatal sepsis and meningitis – a (still) poorly recognised agent
description	Human parechovirus (HPeV), a Picornaviridae virus, is a microorganism associated with respiratory and gastrointestinal infections, in most cases with a benign clinical course. However, some serotypes have been recently associated with a more serious clinical outcome in young children, namely sepsis-like disease and meningitis. In this report, we describe the case of a previously healthy, 11-day-old infant in our Paediatric Emergency Department who presented with high fever, irritability and poor feeding. No other accompanying symptoms, such as respiratory, gastrointestinal or urinary, were shown by the patient. Family history unveiled an 18-month-old sibling with an upper respiratory tract infection. Physical examination was unremarkable. Laboratory testing revealed a normal total white cell count with lymphopenia and a maximum C-reactive protein value of 21.4 mg/L. Cerebrospinal fluid (CSF) analysis showed pleocytosis with high proteinorrachia and normal glycorrhachia. With the clinical suspicion of sepsis, she was hospitalized for clinical surveillance, and empirical antibiotics were administered. Although the bacteriological exams of blood and CSF were negative, RNA of an HPeV was detected in the CSF. She had a favourable clinical course, the cerebral ultrasound was normal, and the clinical follow-up showed adequate psychomotor development until today (18 months old). Recent publications suggested HPeV as one of the major agents of neonatal sepsis and meningitis. Similarly, several other studies reported significant neurological impairments in infants with HPeV infection. In line with these recent findings, we believe this clinical case further supports the need for more extensive research in viral aetiology and in particular of this, not so uncommon, agent in order to avoid unnecessary and potentially harmful interventions in newborns presenting with a sepsis-like clinical picture.
format	article
author	Raquel Garrido Joana Antunes Helena Pedroso Madalena Fialho Manuel Cunha
author_facet	Raquel Garrido Joana Antunes Helena Pedroso Madalena Fialho Manuel Cunha
author_sort	Raquel Garrido
title	Parechovirus neonatal sepsis and meningitis – a (still) poorly recognised agent
title_short	Parechovirus neonatal sepsis and meningitis – a (still) poorly recognised agent
title_full	Parechovirus neonatal sepsis and meningitis – a (still) poorly recognised agent
title_fullStr	Parechovirus neonatal sepsis and meningitis – a (still) poorly recognised agent
title_full_unstemmed	Parechovirus neonatal sepsis and meningitis – a (still) poorly recognised agent
title_sort	parechovirus neonatal sepsis and meningitis – a (still) poorly recognised agent
publisher	Hygeia Press di Corridori Marinella
publishDate	2021
url	https://doaj.org/article/b8844f63e7f14446b993b7c5098e6227
work_keys_str_mv	AT raquelgarrido parechovirusneonatalsepsisandmeningitisastillpoorlyrecognisedagent AT joanaantunes parechovirusneonatalsepsisandmeningitisastillpoorlyrecognisedagent AT helenapedroso parechovirusneonatalsepsisandmeningitisastillpoorlyrecognisedagent AT madalenafialho parechovirusneonatalsepsisandmeningitisastillpoorlyrecognisedagent AT manuelcunha parechovirusneonatalsepsisandmeningitisastillpoorlyrecognisedagent
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Parechovirus neonatal sepsis and meningitis – a (still) poorly recognised agent

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