A Physiological-Based Model for Simulating the Bioavailability and Kinetics of Sulforaphane from Broccoli Products

There are no known physiological-based digestion models that depict glucoraphanin (GR) to sulforaphane (SR) conversion and subsequent absorption. The aim of this research was to make a physiological-based digestion model that includes SR formation, both by endogenous myrosinase and gut bacterial enz...

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Autores principales:	Quchat Shekarri, Matthijs Dekker
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	physiological-based model sulforaphane glucoraphanin compartmental model broccoli bioavailability Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/b88533f3681c4f8b886f938e6a0d8a05
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spelling	oai:doaj.org-article:b88533f3681c4f8b886f938e6a0d8a052021-11-25T17:35:19ZA Physiological-Based Model for Simulating the Bioavailability and Kinetics of Sulforaphane from Broccoli Products10.3390/foods101127612304-8158https://doaj.org/article/b88533f3681c4f8b886f938e6a0d8a052021-11-01T00:00:00Zhttps://www.mdpi.com/2304-8158/10/11/2761https://doaj.org/toc/2304-8158There are no known physiological-based digestion models that depict glucoraphanin (GR) to sulforaphane (SR) conversion and subsequent absorption. The aim of this research was to make a physiological-based digestion model that includes SR formation, both by endogenous myrosinase and gut bacterial enzymes, and to simulate the SR bioavailability. An 18-compartment model (mouth, two stomach, seven small intestine, seven large intestine, and blood compartments) describing transit, reactions and absorption was made. The model, consisting of differential equations, was fit to data from a human intervention study using Mathwork’s Simulink and Matlab software. SR urine metabolite data from participants who consumed different broccoli products were used to estimate several model parameters and validate the model. The products had high, medium, low, and zero myrosinase content. The model’s predicted values fit the experimental values very well. Parity plots showed that the predicted values closely matched experimental values for the high (<i>r</i><sup>2</sup> = 0.95), and low (<i>r</i><sup>2</sup> = 0.93) products, but less so for the medium (<i>r</i><sup>2</sup> = 0.85) and zero (<i>r</i><sup>2</sup> = 0.78) myrosinase products. This is the first physiological-based model to depict the unique bioconversion processes of bioactive SR from broccoli. This model represents a preliminary step in creating a predictive model for the biological effect of SR, which can be used in the growing field of personalized nutrition.Quchat ShekarriMatthijs DekkerMDPI AGarticlephysiological-based modelsulforaphaneglucoraphanincompartmental modelbroccolibioavailabilityChemical technologyTP1-1185ENFoods, Vol 10, Iss 2761, p 2761 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	physiological-based model sulforaphane glucoraphanin compartmental model broccoli bioavailability Chemical technology TP1-1185
spellingShingle	physiological-based model sulforaphane glucoraphanin compartmental model broccoli bioavailability Chemical technology TP1-1185 Quchat Shekarri Matthijs Dekker A Physiological-Based Model for Simulating the Bioavailability and Kinetics of Sulforaphane from Broccoli Products
description	There are no known physiological-based digestion models that depict glucoraphanin (GR) to sulforaphane (SR) conversion and subsequent absorption. The aim of this research was to make a physiological-based digestion model that includes SR formation, both by endogenous myrosinase and gut bacterial enzymes, and to simulate the SR bioavailability. An 18-compartment model (mouth, two stomach, seven small intestine, seven large intestine, and blood compartments) describing transit, reactions and absorption was made. The model, consisting of differential equations, was fit to data from a human intervention study using Mathwork’s Simulink and Matlab software. SR urine metabolite data from participants who consumed different broccoli products were used to estimate several model parameters and validate the model. The products had high, medium, low, and zero myrosinase content. The model’s predicted values fit the experimental values very well. Parity plots showed that the predicted values closely matched experimental values for the high (<i>r</i><sup>2</sup> = 0.95), and low (<i>r</i><sup>2</sup> = 0.93) products, but less so for the medium (<i>r</i><sup>2</sup> = 0.85) and zero (<i>r</i><sup>2</sup> = 0.78) myrosinase products. This is the first physiological-based model to depict the unique bioconversion processes of bioactive SR from broccoli. This model represents a preliminary step in creating a predictive model for the biological effect of SR, which can be used in the growing field of personalized nutrition.
format	article
author	Quchat Shekarri Matthijs Dekker
author_facet	Quchat Shekarri Matthijs Dekker
author_sort	Quchat Shekarri
title	A Physiological-Based Model for Simulating the Bioavailability and Kinetics of Sulforaphane from Broccoli Products
title_short	A Physiological-Based Model for Simulating the Bioavailability and Kinetics of Sulforaphane from Broccoli Products
title_full	A Physiological-Based Model for Simulating the Bioavailability and Kinetics of Sulforaphane from Broccoli Products
title_fullStr	A Physiological-Based Model for Simulating the Bioavailability and Kinetics of Sulforaphane from Broccoli Products
title_full_unstemmed	A Physiological-Based Model for Simulating the Bioavailability and Kinetics of Sulforaphane from Broccoli Products
title_sort	physiological-based model for simulating the bioavailability and kinetics of sulforaphane from broccoli products
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b88533f3681c4f8b886f938e6a0d8a05
work_keys_str_mv	AT quchatshekarri aphysiologicalbasedmodelforsimulatingthebioavailabilityandkineticsofsulforaphanefrombroccoliproducts AT matthijsdekker aphysiologicalbasedmodelforsimulatingthebioavailabilityandkineticsofsulforaphanefrombroccoliproducts AT quchatshekarri physiologicalbasedmodelforsimulatingthebioavailabilityandkineticsofsulforaphanefrombroccoliproducts AT matthijsdekker physiologicalbasedmodelforsimulatingthebioavailabilityandkineticsofsulforaphanefrombroccoliproducts
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A Physiological-Based Model for Simulating the Bioavailability and Kinetics of Sulforaphane from Broccoli Products

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