Detecting Progression of Treated Choroidal Melanomas: Is Ultrasonography Necessary?

Prompt detection and treatment of local treatment failure after radiotherapy for choroidal melanoma optimises any opportunities for conserving vision and the eye, possibly reducing an increased risk of metastatic disease. Long-term surveillance is therefore required but is hampered by the perceived...

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Autores principales:	Guy S. Negretti, Umiya Harley, Amit K. Arora, Gordon Hay, Mandeep S. Sagoo, Bertil E. Damato
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	uveal melanoma recurrence long-term surveillance imaging modalities Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/b885c27ef2344c0593b48f8990abe15f
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spelling	oai:doaj.org-article:b885c27ef2344c0593b48f8990abe15f2021-11-25T17:04:33ZDetecting Progression of Treated Choroidal Melanomas: Is Ultrasonography Necessary?10.3390/cancers132258322072-6694https://doaj.org/article/b885c27ef2344c0593b48f8990abe15f2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5832https://doaj.org/toc/2072-6694Prompt detection and treatment of local treatment failure after radiotherapy for choroidal melanoma optimises any opportunities for conserving vision and the eye, possibly reducing an increased risk of metastatic disease. Long-term surveillance is therefore required but is hampered by the perceived need to perform ultrasonography, which may not be available at a patient’s local hospital. The aim of this study was to determine whether local treatment failure can reliably be detected with colour fundus photography alone, and, if so, in which patients. Patients were included in the study if diagnosed with local treatment failure between April 2016 and February 2021 after eye-conserving therapy for choroidal melanoma. Wide-field colour and fundal autofluorescence (FAF) images, optical coherence tomography (OCT), and ultrasonography (US) were analysed by two of the authors (GN and UH). The cohort included 87 patients with local treatment failure. In 75 patients with clear media, tumour progression was detected by colour photography alone in 74 (98.7%) patients. Sensitivity was not increased by the addition of either OCT or AF. One patient with clear media developed extraocular extension detected with US without visible change in the intraocular part of the tumour. In the other 12 patients, US was required because of opaque media and a consequently poor fundal view. Local treatment failure after radiotherapy for choroidal melanoma is detected in 98.7% of cases with colour photography when the media are clear. Ultrasonography is useful when photography is prevented by opaque media or tumours having locations in the far periphery.Guy S. NegrettiUmiya HarleyAmit K. AroraGordon HayMandeep S. SagooBertil E. DamatoMDPI AGarticleuveal melanomarecurrencelong-term surveillanceimaging modalitiesNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5832, p 5832 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	uveal melanoma recurrence long-term surveillance imaging modalities Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	uveal melanoma recurrence long-term surveillance imaging modalities Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Guy S. Negretti Umiya Harley Amit K. Arora Gordon Hay Mandeep S. Sagoo Bertil E. Damato Detecting Progression of Treated Choroidal Melanomas: Is Ultrasonography Necessary?
description	Prompt detection and treatment of local treatment failure after radiotherapy for choroidal melanoma optimises any opportunities for conserving vision and the eye, possibly reducing an increased risk of metastatic disease. Long-term surveillance is therefore required but is hampered by the perceived need to perform ultrasonography, which may not be available at a patient’s local hospital. The aim of this study was to determine whether local treatment failure can reliably be detected with colour fundus photography alone, and, if so, in which patients. Patients were included in the study if diagnosed with local treatment failure between April 2016 and February 2021 after eye-conserving therapy for choroidal melanoma. Wide-field colour and fundal autofluorescence (FAF) images, optical coherence tomography (OCT), and ultrasonography (US) were analysed by two of the authors (GN and UH). The cohort included 87 patients with local treatment failure. In 75 patients with clear media, tumour progression was detected by colour photography alone in 74 (98.7%) patients. Sensitivity was not increased by the addition of either OCT or AF. One patient with clear media developed extraocular extension detected with US without visible change in the intraocular part of the tumour. In the other 12 patients, US was required because of opaque media and a consequently poor fundal view. Local treatment failure after radiotherapy for choroidal melanoma is detected in 98.7% of cases with colour photography when the media are clear. Ultrasonography is useful when photography is prevented by opaque media or tumours having locations in the far periphery.
format	article
author	Guy S. Negretti Umiya Harley Amit K. Arora Gordon Hay Mandeep S. Sagoo Bertil E. Damato
author_facet	Guy S. Negretti Umiya Harley Amit K. Arora Gordon Hay Mandeep S. Sagoo Bertil E. Damato
author_sort	Guy S. Negretti
title	Detecting Progression of Treated Choroidal Melanomas: Is Ultrasonography Necessary?
title_short	Detecting Progression of Treated Choroidal Melanomas: Is Ultrasonography Necessary?
title_full	Detecting Progression of Treated Choroidal Melanomas: Is Ultrasonography Necessary?
title_fullStr	Detecting Progression of Treated Choroidal Melanomas: Is Ultrasonography Necessary?
title_full_unstemmed	Detecting Progression of Treated Choroidal Melanomas: Is Ultrasonography Necessary?
title_sort	detecting progression of treated choroidal melanomas: is ultrasonography necessary?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b885c27ef2344c0593b48f8990abe15f
work_keys_str_mv	AT guysnegretti detectingprogressionoftreatedchoroidalmelanomasisultrasonographynecessary AT umiyaharley detectingprogressionoftreatedchoroidalmelanomasisultrasonographynecessary AT amitkarora detectingprogressionoftreatedchoroidalmelanomasisultrasonographynecessary AT gordonhay detectingprogressionoftreatedchoroidalmelanomasisultrasonographynecessary AT mandeepssagoo detectingprogressionoftreatedchoroidalmelanomasisultrasonographynecessary AT bertiledamato detectingprogressionoftreatedchoroidalmelanomasisultrasonographynecessary
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Detecting Progression of Treated Choroidal Melanomas: Is Ultrasonography Necessary?

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