A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism

Ceramides are signalling molecules that regulate several physiological functions including insulin sensitivity. Here the authors report a selective ceramide synthase 1 inhibitor that counteracts lipid accumulation within the muscle and adiposity by increasing fatty acid oxidation but without affecti...

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Autores principales:	Nigel Turner, Xin Ying Lim, Hamish D. Toop, Brenna Osborne, Amanda E. Brandon, Elysha N. Taylor, Corrine E. Fiveash, Hemna Govindaraju, Jonathan D. Teo, Holly P. McEwen, Timothy A. Couttas, Stephen M. Butler, Abhirup Das, Greg M. Kowalski, Clinton R. Bruce, Kyle L. Hoehn, Thomas Fath, Carsten Schmitz-Peiffer, Gregory J. Cooney, Magdalene K. Montgomery, Jonathan C. Morris, Anthony S. Don
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b889316af6b04ac29b1836b3ff8bcb97
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spelling	oai:doaj.org-article:b889316af6b04ac29b1836b3ff8bcb972021-12-02T16:49:33ZA selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism10.1038/s41467-018-05613-72041-1723https://doaj.org/article/b889316af6b04ac29b1836b3ff8bcb972018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05613-7https://doaj.org/toc/2041-1723Ceramides are signalling molecules that regulate several physiological functions including insulin sensitivity. Here the authors report a selective ceramide synthase 1 inhibitor that counteracts lipid accumulation within the muscle and adiposity by increasing fatty acid oxidation but without affecting insulin sensitivity in mice fed with an obesogenic diet.Nigel TurnerXin Ying LimHamish D. ToopBrenna OsborneAmanda E. BrandonElysha N. TaylorCorrine E. FiveashHemna GovindarajuJonathan D. TeoHolly P. McEwenTimothy A. CouttasStephen M. ButlerAbhirup DasGreg M. KowalskiClinton R. BruceKyle L. HoehnThomas FathCarsten Schmitz-PeifferGregory J. CooneyMagdalene K. MontgomeryJonathan C. MorrisAnthony S. DonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nigel Turner Xin Ying Lim Hamish D. Toop Brenna Osborne Amanda E. Brandon Elysha N. Taylor Corrine E. Fiveash Hemna Govindaraju Jonathan D. Teo Holly P. McEwen Timothy A. Couttas Stephen M. Butler Abhirup Das Greg M. Kowalski Clinton R. Bruce Kyle L. Hoehn Thomas Fath Carsten Schmitz-Peiffer Gregory J. Cooney Magdalene K. Montgomery Jonathan C. Morris Anthony S. Don A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism
description	Ceramides are signalling molecules that regulate several physiological functions including insulin sensitivity. Here the authors report a selective ceramide synthase 1 inhibitor that counteracts lipid accumulation within the muscle and adiposity by increasing fatty acid oxidation but without affecting insulin sensitivity in mice fed with an obesogenic diet.
format	article
author	Nigel Turner Xin Ying Lim Hamish D. Toop Brenna Osborne Amanda E. Brandon Elysha N. Taylor Corrine E. Fiveash Hemna Govindaraju Jonathan D. Teo Holly P. McEwen Timothy A. Couttas Stephen M. Butler Abhirup Das Greg M. Kowalski Clinton R. Bruce Kyle L. Hoehn Thomas Fath Carsten Schmitz-Peiffer Gregory J. Cooney Magdalene K. Montgomery Jonathan C. Morris Anthony S. Don
author_facet	Nigel Turner Xin Ying Lim Hamish D. Toop Brenna Osborne Amanda E. Brandon Elysha N. Taylor Corrine E. Fiveash Hemna Govindaraju Jonathan D. Teo Holly P. McEwen Timothy A. Couttas Stephen M. Butler Abhirup Das Greg M. Kowalski Clinton R. Bruce Kyle L. Hoehn Thomas Fath Carsten Schmitz-Peiffer Gregory J. Cooney Magdalene K. Montgomery Jonathan C. Morris Anthony S. Don
author_sort	Nigel Turner
title	A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism
title_short	A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism
title_full	A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism
title_fullStr	A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism
title_full_unstemmed	A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism
title_sort	selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b889316af6b04ac29b1836b3ff8bcb97
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A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism

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