Relationship between abnormal glucose metabolism and osteoporosis in Han Chinese men over the age of 50 years

Relationship between abnormal glucose metabolism and osteoporosis in Han Chinese men over the age of 50 years

Minyan Liu, Yanhui Lu, Xiaoling Cheng, Lichao Ma, Xinyu Miao, Nan Li, Boruo Sun, Shuangtong Yan, Jian Li, Chunling Li Department of Elderly Endocrinology, Chinese PLA General Hospital, Haidian District, Beijing 100853, China Aim: The aim of this study was to determine the relationship between abno...

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Autores principales: Liu M, Lu Y, Cheng X, Ma L, Miao X, Li N, Sun B, Yan S, Li J, Li C
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2019
Materias:
Diabetes mellitus
Osteoporosis
Bone mineral density
Bone turnover markers
Geriatrics
RC952-954.6
Acceso en línea:https://doaj.org/article/b88b4d5fe95d43a98508d179f0fde6d7
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spelling oai:doaj.org-article:b88b4d5fe95d43a98508d179f0fde6d72021-12-02T03:27:28ZRelationship between abnormal glucose metabolism and osteoporosis in Han Chinese men over the age of 50 years1178-1998https://doaj.org/article/b88b4d5fe95d43a98508d179f0fde6d72019-02-01T00:00:00Zhttps://www.dovepress.com/relationship-between-abnormal-glucose-metabolism-and-osteoporosis-in-h-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Minyan Liu, Yanhui Lu, Xiaoling Cheng, Lichao Ma, Xinyu Miao, Nan Li, Boruo Sun, Shuangtong Yan, Jian Li, Chunling Li Department of Elderly Endocrinology, Chinese PLA General Hospital, Haidian District, Beijing 100853, China Aim: The aim of this study was to determine the relationship between abnormal glucose metabolism and osteoporosis (OP) in Han Chinese men over the age of 50 years. Patients and methods: A cross-sectional study of 775 male patients aged over 50 years was performed at our hospital in 2011. The patients were divided into a normal glucose metabolism group, an impaired glucose regulation (IGR) group, and a type 2 diabetes mellitus (T2DM) group. Differences in their bone mineral densities (BMDs), OP detection rates, and indices of bone metabolism were assessed. Results: After adjusting for age and body mass index (BMI), there were no significant differences in lumbar spine, femoral neck, and total hip BMD values in the three groups (P>0.05) nor in OP detection rates (P=0.19). However, there were some significant differences in bone metabolism markers between the groups after adjusting for age, BMI, and serum creatinine (Cr): 25-hydroxyvitamin D (25(OH)D) was positively correlated with the presence of abnormal glycometabolism (r=0.08; P<0.01), while β-carboxy-terminal cross-linking telopeptide of type I collagen (β-CTX), bone gamma-carboxyglutamic acid protein (BGP; osteocalcin [OC]), and procollagen type 1 intact N-terminal propeptide (P1NP) were negatively correlated (r=-0.13, -0.21, -0.14, respectively; P<0.01). Logistic regression analysis of the data indicated that BGP was the only bone metabolism marker significantly influenced by abnormal glucose metabolism (OR =0.96). Conclusion: There were no significant differences in BMD or OP detection rates between the three glycometabolism groups after adjusting for age and BMI. However, the bone metabolism marker, BGP, was significantly negatively correlated with abnormal glucose metabolism. Keywords: diabetes mellitus, osteoporosis, bone mineral density, bone turnover markersLiu MLu YCheng XMa LMiao XLi NSun BYan SLi JLi CDove Medical PressarticleDiabetes mellitusOsteoporosisBone mineral densityBone turnover markersGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 14, Pp 445-451 (2019)
institution DOAJ
collection DOAJ
language EN
topic Diabetes mellitus
Osteoporosis
Bone mineral density
Bone turnover markers
Geriatrics
RC952-954.6
spellingShingle Diabetes mellitus
Osteoporosis
Bone mineral density
Bone turnover markers
Geriatrics
RC952-954.6
Liu M
Lu Y
Cheng X
Ma L
Miao X
Li N
Sun B
Yan S
Li J
Li C
Relationship between abnormal glucose metabolism and osteoporosis in Han Chinese men over the age of 50 years
description Minyan Liu, Yanhui Lu, Xiaoling Cheng, Lichao Ma, Xinyu Miao, Nan Li, Boruo Sun, Shuangtong Yan, Jian Li, Chunling Li Department of Elderly Endocrinology, Chinese PLA General Hospital, Haidian District, Beijing 100853, China Aim: The aim of this study was to determine the relationship between abnormal glucose metabolism and osteoporosis (OP) in Han Chinese men over the age of 50 years. Patients and methods: A cross-sectional study of 775 male patients aged over 50 years was performed at our hospital in 2011. The patients were divided into a normal glucose metabolism group, an impaired glucose regulation (IGR) group, and a type 2 diabetes mellitus (T2DM) group. Differences in their bone mineral densities (BMDs), OP detection rates, and indices of bone metabolism were assessed. Results: After adjusting for age and body mass index (BMI), there were no significant differences in lumbar spine, femoral neck, and total hip BMD values in the three groups (P>0.05) nor in OP detection rates (P=0.19). However, there were some significant differences in bone metabolism markers between the groups after adjusting for age, BMI, and serum creatinine (Cr): 25-hydroxyvitamin D (25(OH)D) was positively correlated with the presence of abnormal glycometabolism (r=0.08; P<0.01), while β-carboxy-terminal cross-linking telopeptide of type I collagen (β-CTX), bone gamma-carboxyglutamic acid protein (BGP; osteocalcin [OC]), and procollagen type 1 intact N-terminal propeptide (P1NP) were negatively correlated (r=-0.13, -0.21, -0.14, respectively; P<0.01). Logistic regression analysis of the data indicated that BGP was the only bone metabolism marker significantly influenced by abnormal glucose metabolism (OR =0.96). Conclusion: There were no significant differences in BMD or OP detection rates between the three glycometabolism groups after adjusting for age and BMI. However, the bone metabolism marker, BGP, was significantly negatively correlated with abnormal glucose metabolism. Keywords: diabetes mellitus, osteoporosis, bone mineral density, bone turnover markers
format article
author Liu M
Lu Y
Cheng X
Ma L
Miao X
Li N
Sun B
Yan S
Li J
Li C
author_facet Liu M
Lu Y
Cheng X
Ma L
Miao X
Li N
Sun B
Yan S
Li J
Li C
author_sort Liu M
title Relationship between abnormal glucose metabolism and osteoporosis in Han Chinese men over the age of 50 years
title_short Relationship between abnormal glucose metabolism and osteoporosis in Han Chinese men over the age of 50 years
title_full Relationship between abnormal glucose metabolism and osteoporosis in Han Chinese men over the age of 50 years
title_fullStr Relationship between abnormal glucose metabolism and osteoporosis in Han Chinese men over the age of 50 years
title_full_unstemmed Relationship between abnormal glucose metabolism and osteoporosis in Han Chinese men over the age of 50 years
title_sort relationship between abnormal glucose metabolism and osteoporosis in han chinese men over the age of 50 years
publisher Dove Medical Press
publishDate 2019
url https://doaj.org/article/b88b4d5fe95d43a98508d179f0fde6d7
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