Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells

Aging involves gradual loss of tissue function, and transcription factor (TF) expression can ameliorate this in progeroid mice. Here the authors show that transient TF expression reverses age-associated epigenetic marks, inflammatory profiles and restores regenerative potential in naturally aged hum...

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Autores principales:	Tapash Jay Sarkar, Marco Quarta, Shravani Mukherjee, Alex Colville, Patrick Paine, Linda Doan, Christopher M. Tran, Constance R. Chu, Steve Horvath, Lei S. Qi, Nidhi Bhutani, Thomas A. Rando, Vittorio Sebastiano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b88ee3f2918443da9a944c8371cd034e
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spelling	oai:doaj.org-article:b88ee3f2918443da9a944c8371cd034e2021-12-02T14:40:28ZTransient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells10.1038/s41467-020-15174-32041-1723https://doaj.org/article/b88ee3f2918443da9a944c8371cd034e2020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15174-3https://doaj.org/toc/2041-1723Aging involves gradual loss of tissue function, and transcription factor (TF) expression can ameliorate this in progeroid mice. Here the authors show that transient TF expression reverses age-associated epigenetic marks, inflammatory profiles and restores regenerative potential in naturally aged human cells.Tapash Jay SarkarMarco QuartaShravani MukherjeeAlex ColvillePatrick PaineLinda DoanChristopher M. TranConstance R. ChuSteve HorvathLei S. QiNidhi BhutaniThomas A. RandoVittorio SebastianoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tapash Jay Sarkar Marco Quarta Shravani Mukherjee Alex Colville Patrick Paine Linda Doan Christopher M. Tran Constance R. Chu Steve Horvath Lei S. Qi Nidhi Bhutani Thomas A. Rando Vittorio Sebastiano Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells
description	Aging involves gradual loss of tissue function, and transcription factor (TF) expression can ameliorate this in progeroid mice. Here the authors show that transient TF expression reverses age-associated epigenetic marks, inflammatory profiles and restores regenerative potential in naturally aged human cells.
format	article
author	Tapash Jay Sarkar Marco Quarta Shravani Mukherjee Alex Colville Patrick Paine Linda Doan Christopher M. Tran Constance R. Chu Steve Horvath Lei S. Qi Nidhi Bhutani Thomas A. Rando Vittorio Sebastiano
author_facet	Tapash Jay Sarkar Marco Quarta Shravani Mukherjee Alex Colville Patrick Paine Linda Doan Christopher M. Tran Constance R. Chu Steve Horvath Lei S. Qi Nidhi Bhutani Thomas A. Rando Vittorio Sebastiano
author_sort	Tapash Jay Sarkar
title	Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells
title_short	Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells
title_full	Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells
title_fullStr	Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells
title_full_unstemmed	Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells
title_sort	transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b88ee3f2918443da9a944c8371cd034e
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Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells

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