The hypoxia-sensor carbonic anhydrase IX affects macrophage metabolism, but is not a suitable biomarker for human cardiovascular disease

The hypoxia-sensor carbonic anhydrase IX affects macrophage metabolism, but is not a suitable biomarker for human cardiovascular disease

Abstract Hypoxia is prevalent in atherosclerotic plaques, promoting plaque aggravation and subsequent cardiovascular disease (CVD). Transmembrane protein carbonic anhydrase IX (CAIX) is hypoxia-induced and can be shed into the circulation as soluble CAIX (sCAIX). As plaque macrophages are hypoxic, w...

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Autores principales: J. A. F. Demandt, L. J. Dubois, K. van Kuijk, M. Zaťovičová, H. Jin, S. Parkkila, S. W. van der Laan, L. Jelenska, B. M. E. Mees, C. P. M. Reutelingsperger, K. B. J. M. Cleutjens, C. J. H. van der Kallen, C. G. Schalkwijk, M. M. J. van Greevenbroek, E. A. L. Biessen, G. Pasterkamp, S. Pastoreková, C. D. A. Stehouwer, J. C. Sluimer
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/b88f767adcdb47aab623eaef420a2b57
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