Numerical optimization of targeted delivery of charged nanoparticles to the ostiomeatal complex for treatment of rhinosinusitis

Jinxiang Xi,1 Jiayao Eddie Yuan,1 Xiuhua April Si,2 James Hasbany1 1School of Engineering and Technology, Central Michigan University, Mount Pleasant, MI, 2Department of Mechanical Engineering, California Baptist University, Riverside, CA, USA Background: Despite the prevalence of rhinosinusitis th...

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Autores principales:	Xi J, Yuan JE, Si XA, Hasbany J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b890c7bdd5ab49f49c38b6f95deb1ba3
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spelling	oai:doaj.org-article:b890c7bdd5ab49f49c38b6f95deb1ba32021-12-02T05:40:44ZNumerical optimization of targeted delivery of charged nanoparticles to the ostiomeatal complex for treatment of rhinosinusitis1178-2013https://doaj.org/article/b890c7bdd5ab49f49c38b6f95deb1ba32015-07-01T00:00:00Zhttp://www.dovepress.com/numerical-optimization-of-targeted-delivery-of-charged-nanoparticles-t-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Jinxiang Xi,1 Jiayao Eddie Yuan,1 Xiuhua April Si,2 James Hasbany1 1School of Engineering and Technology, Central Michigan University, Mount Pleasant, MI, 2Department of Mechanical Engineering, California Baptist University, Riverside, CA, USA Background: Despite the prevalence of rhinosinusitis that affects 10%–15% of the population, current inhalation therapy shows limited efficacy. Standard devices deliver <5% of the drugs to the sinuses due to the complexity of nose structure, secluded location of the sinus, poor ventilation, and lack of control of particle motions inside the nasal cavity. Methods: An electric-guided delivery system was developed to guide charged particles to the ostiomeatal complex (OMC). Its performance was numerically assessed in an MRI-based nose–sinus model. Key design variables related to the delivery device, drug particles, and patient breathing were determined using sensitivity analysis. A two-stage optimization of design variables was conducted to obtain the best performance of the delivery system using the Nelder-Mead algorithm. Results and discussion: The OMC delivery system exhibited high sensitivity to the applied electric field and electrostatic charges carried by the particles. Through the synthesis of electric guidance and point drug release, the new delivery system eliminated particle deposition in the nasal valve and turbinate regions and significantly enhanced the OMC doses. An OMC delivery efficiency of 72.4% was obtained with the optimized design, which is one order of magnitude higher than the standard nasal devices. Moreover, optimization is imperative to achieve a sound delivery protocol because of the large number of design variables. The OMC dose increased from 45.0% in the baseline model to 72.4% in the optimized system. The optimization framework developed in this study can be easily adapted for the delivery of drugs to other sites in the nose such as the ethmoid sinus and olfactory region. Keywords: maxillary sinus, rhinosinusitis, intranasal aerosol drug delivery, charged particles, electric guidance, ostiomeatal complexXi JYuan JESi XAHasbany JDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 4847-4861 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Xi J Yuan JE Si XA Hasbany J Numerical optimization of targeted delivery of charged nanoparticles to the ostiomeatal complex for treatment of rhinosinusitis
description	Jinxiang Xi,1 Jiayao Eddie Yuan,1 Xiuhua April Si,2 James Hasbany1 1School of Engineering and Technology, Central Michigan University, Mount Pleasant, MI, 2Department of Mechanical Engineering, California Baptist University, Riverside, CA, USA Background: Despite the prevalence of rhinosinusitis that affects 10%–15% of the population, current inhalation therapy shows limited efficacy. Standard devices deliver <5% of the drugs to the sinuses due to the complexity of nose structure, secluded location of the sinus, poor ventilation, and lack of control of particle motions inside the nasal cavity. Methods: An electric-guided delivery system was developed to guide charged particles to the ostiomeatal complex (OMC). Its performance was numerically assessed in an MRI-based nose–sinus model. Key design variables related to the delivery device, drug particles, and patient breathing were determined using sensitivity analysis. A two-stage optimization of design variables was conducted to obtain the best performance of the delivery system using the Nelder-Mead algorithm. Results and discussion: The OMC delivery system exhibited high sensitivity to the applied electric field and electrostatic charges carried by the particles. Through the synthesis of electric guidance and point drug release, the new delivery system eliminated particle deposition in the nasal valve and turbinate regions and significantly enhanced the OMC doses. An OMC delivery efficiency of 72.4% was obtained with the optimized design, which is one order of magnitude higher than the standard nasal devices. Moreover, optimization is imperative to achieve a sound delivery protocol because of the large number of design variables. The OMC dose increased from 45.0% in the baseline model to 72.4% in the optimized system. The optimization framework developed in this study can be easily adapted for the delivery of drugs to other sites in the nose such as the ethmoid sinus and olfactory region. Keywords: maxillary sinus, rhinosinusitis, intranasal aerosol drug delivery, charged particles, electric guidance, ostiomeatal complex
format	article
author	Xi J Yuan JE Si XA Hasbany J
author_facet	Xi J Yuan JE Si XA Hasbany J
author_sort	Xi J
title	Numerical optimization of targeted delivery of charged nanoparticles to the ostiomeatal complex for treatment of rhinosinusitis
title_short	Numerical optimization of targeted delivery of charged nanoparticles to the ostiomeatal complex for treatment of rhinosinusitis
title_full	Numerical optimization of targeted delivery of charged nanoparticles to the ostiomeatal complex for treatment of rhinosinusitis
title_fullStr	Numerical optimization of targeted delivery of charged nanoparticles to the ostiomeatal complex for treatment of rhinosinusitis
title_full_unstemmed	Numerical optimization of targeted delivery of charged nanoparticles to the ostiomeatal complex for treatment of rhinosinusitis
title_sort	numerical optimization of targeted delivery of charged nanoparticles to the ostiomeatal complex for treatment of rhinosinusitis
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/b890c7bdd5ab49f49c38b6f95deb1ba3
work_keys_str_mv	AT xij numericaloptimizationoftargeteddeliveryofchargednanoparticlestotheostiomeatalcomplexfortreatmentofrhinosinusitis AT yuanje numericaloptimizationoftargeteddeliveryofchargednanoparticlestotheostiomeatalcomplexfortreatmentofrhinosinusitis AT sixa numericaloptimizationoftargeteddeliveryofchargednanoparticlestotheostiomeatalcomplexfortreatmentofrhinosinusitis AT hasbanyj numericaloptimizationoftargeteddeliveryofchargednanoparticlestotheostiomeatalcomplexfortreatmentofrhinosinusitis
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Numerical optimization of targeted delivery of charged nanoparticles to the ostiomeatal complex for treatment of rhinosinusitis

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