The role of surgery on primary site in metastatic upper urinary tract urothelial carcinoma and a nomogram for predicting the survival of patients with metastatic upper urinary tract urothelial carcinoma

Abstract Metastatic upper urinary tract urothelial carcinoma (mUTUC) is a relatively rare urothelial carcinoma, and little attention has been given to it. Our study established a nomogram by analyzing the prognostic factors of mUTUC to predict the survival of patients and revealed that the role of s...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xiaodi Zhang, Ping Wang, Kaiyan QI, Qiao Qiao, Yuanjun Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	metastasis nomogram SEER surgical therapy urothelial Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/b891842e658f49c68c117d627c018f68
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b891842e658f49c68c117d627c018f68
record_format	dspace
spelling	oai:doaj.org-article:b891842e658f49c68c117d627c018f682021-11-22T09:08:48ZThe role of surgery on primary site in metastatic upper urinary tract urothelial carcinoma and a nomogram for predicting the survival of patients with metastatic upper urinary tract urothelial carcinoma2045-763410.1002/cam4.4327https://doaj.org/article/b891842e658f49c68c117d627c018f682021-11-01T00:00:00Zhttps://doi.org/10.1002/cam4.4327https://doaj.org/toc/2045-7634Abstract Metastatic upper urinary tract urothelial carcinoma (mUTUC) is a relatively rare urothelial carcinoma, and little attention has been given to it. Our study established a nomogram by analyzing the prognostic factors of mUTUC to predict the survival of patients and revealed that the role of surgery at the primary tumor site. We extracted our data (2010–2016) from the Surveillance, Epidemiology, and End Results (SEER) database, and 628 patients with distant metastasis were identified. Propensity score matching (PSM) was used to balance the clinical variable bias in a 1:1 ratio. After PSM, we enrolled 502 patients in our study cohort. Univariate and multivariate Cox regression analyses and Kaplan–Meier curves showed that T stage, N stage, hepatic metastasis, surgery, and chemotherapy were prognostic factors for mUTUC before and after PSM. Based on the findings, a nomogram was constructed to predict the 12‐month survival of patients with distant metastasis. The analysis of subgroups of T stage, N stage, and different metastatic sites demonstrated that the survival of patients with T1/T2, N0/N1/N2/N3, metastasis including liver, and metastasis including bone could be improved by a combination of surgery and chemotherapy, while for the patients with T3/T4/TX, NX, metastasis including lung, and metastasis including distant lymph nodes, chemotherapy alone was a better choice to improve their overall survival. Radiotherapy has been proven to be useful for patients with N1/N2/N3 stage. We have provided more precise treatment strategies for stage IV patients. Our research fully affirms the role of surgery on primary site in UTUC patients with distant metastasis and the significance of classifying the patients into subgroups by integrating variables including T stage, N stage, and different metastatic sites to select the optimal treatment method.Xiaodi ZhangPing WangKaiyan QIQiao QiaoYuanjun JiangWileyarticlemetastasisnomogramSEERsurgical therapyurothelialNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancer Medicine, Vol 10, Iss 22, Pp 8079-8090 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	metastasis nomogram SEER surgical therapy urothelial Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	metastasis nomogram SEER surgical therapy urothelial Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Xiaodi Zhang Ping Wang Kaiyan QI Qiao Qiao Yuanjun Jiang The role of surgery on primary site in metastatic upper urinary tract urothelial carcinoma and a nomogram for predicting the survival of patients with metastatic upper urinary tract urothelial carcinoma
description	Abstract Metastatic upper urinary tract urothelial carcinoma (mUTUC) is a relatively rare urothelial carcinoma, and little attention has been given to it. Our study established a nomogram by analyzing the prognostic factors of mUTUC to predict the survival of patients and revealed that the role of surgery at the primary tumor site. We extracted our data (2010–2016) from the Surveillance, Epidemiology, and End Results (SEER) database, and 628 patients with distant metastasis were identified. Propensity score matching (PSM) was used to balance the clinical variable bias in a 1:1 ratio. After PSM, we enrolled 502 patients in our study cohort. Univariate and multivariate Cox regression analyses and Kaplan–Meier curves showed that T stage, N stage, hepatic metastasis, surgery, and chemotherapy were prognostic factors for mUTUC before and after PSM. Based on the findings, a nomogram was constructed to predict the 12‐month survival of patients with distant metastasis. The analysis of subgroups of T stage, N stage, and different metastatic sites demonstrated that the survival of patients with T1/T2, N0/N1/N2/N3, metastasis including liver, and metastasis including bone could be improved by a combination of surgery and chemotherapy, while for the patients with T3/T4/TX, NX, metastasis including lung, and metastasis including distant lymph nodes, chemotherapy alone was a better choice to improve their overall survival. Radiotherapy has been proven to be useful for patients with N1/N2/N3 stage. We have provided more precise treatment strategies for stage IV patients. Our research fully affirms the role of surgery on primary site in UTUC patients with distant metastasis and the significance of classifying the patients into subgroups by integrating variables including T stage, N stage, and different metastatic sites to select the optimal treatment method.
format	article
author	Xiaodi Zhang Ping Wang Kaiyan QI Qiao Qiao Yuanjun Jiang
author_facet	Xiaodi Zhang Ping Wang Kaiyan QI Qiao Qiao Yuanjun Jiang
author_sort	Xiaodi Zhang
title	The role of surgery on primary site in metastatic upper urinary tract urothelial carcinoma and a nomogram for predicting the survival of patients with metastatic upper urinary tract urothelial carcinoma
title_short	The role of surgery on primary site in metastatic upper urinary tract urothelial carcinoma and a nomogram for predicting the survival of patients with metastatic upper urinary tract urothelial carcinoma
title_full	The role of surgery on primary site in metastatic upper urinary tract urothelial carcinoma and a nomogram for predicting the survival of patients with metastatic upper urinary tract urothelial carcinoma
title_fullStr	The role of surgery on primary site in metastatic upper urinary tract urothelial carcinoma and a nomogram for predicting the survival of patients with metastatic upper urinary tract urothelial carcinoma
title_full_unstemmed	The role of surgery on primary site in metastatic upper urinary tract urothelial carcinoma and a nomogram for predicting the survival of patients with metastatic upper urinary tract urothelial carcinoma
title_sort	role of surgery on primary site in metastatic upper urinary tract urothelial carcinoma and a nomogram for predicting the survival of patients with metastatic upper urinary tract urothelial carcinoma
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/b891842e658f49c68c117d627c018f68
work_keys_str_mv	AT xiaodizhang theroleofsurgeryonprimarysiteinmetastaticupperurinarytracturothelialcarcinomaandanomogramforpredictingthesurvivalofpatientswithmetastaticupperurinarytracturothelialcarcinoma AT pingwang theroleofsurgeryonprimarysiteinmetastaticupperurinarytracturothelialcarcinomaandanomogramforpredictingthesurvivalofpatientswithmetastaticupperurinarytracturothelialcarcinoma AT kaiyanqi theroleofsurgeryonprimarysiteinmetastaticupperurinarytracturothelialcarcinomaandanomogramforpredictingthesurvivalofpatientswithmetastaticupperurinarytracturothelialcarcinoma AT qiaoqiao theroleofsurgeryonprimarysiteinmetastaticupperurinarytracturothelialcarcinomaandanomogramforpredictingthesurvivalofpatientswithmetastaticupperurinarytracturothelialcarcinoma AT yuanjunjiang theroleofsurgeryonprimarysiteinmetastaticupperurinarytracturothelialcarcinomaandanomogramforpredictingthesurvivalofpatientswithmetastaticupperurinarytracturothelialcarcinoma AT xiaodizhang roleofsurgeryonprimarysiteinmetastaticupperurinarytracturothelialcarcinomaandanomogramforpredictingthesurvivalofpatientswithmetastaticupperurinarytracturothelialcarcinoma AT pingwang roleofsurgeryonprimarysiteinmetastaticupperurinarytracturothelialcarcinomaandanomogramforpredictingthesurvivalofpatientswithmetastaticupperurinarytracturothelialcarcinoma AT kaiyanqi roleofsurgeryonprimarysiteinmetastaticupperurinarytracturothelialcarcinomaandanomogramforpredictingthesurvivalofpatientswithmetastaticupperurinarytracturothelialcarcinoma AT qiaoqiao roleofsurgeryonprimarysiteinmetastaticupperurinarytracturothelialcarcinomaandanomogramforpredictingthesurvivalofpatientswithmetastaticupperurinarytracturothelialcarcinoma AT yuanjunjiang roleofsurgeryonprimarysiteinmetastaticupperurinarytracturothelialcarcinomaandanomogramforpredictingthesurvivalofpatientswithmetastaticupperurinarytracturothelialcarcinoma
_version_	1718417816606998528

The role of surgery on primary site in metastatic upper urinary tract urothelial carcinoma and a nomogram for predicting the survival of patients with metastatic upper urinary tract urothelial carcinoma

Ejemplares similares