Pixelwise H-score: A novel digital image analysis-based metric to quantify membrane biomarker expression from immunohistochemistry images.

Immunohistochemistry (IHC) assays play a central role in evaluating biomarker expression in tissue sections for diagnostic and research applications. Manual scoring of IHC images, which is the current standard of practice, is known to have several shortcomings in terms of reproducibility and scalabi...

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Autores principales: Sripad Ram, Pamela Vizcarra, Pamela Whalen, Shibing Deng, C L Painter, Amy Jackson-Fisher, Steven Pirie-Shepherd, Xiaoling Xia, Eric L Powell
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
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Acceso en línea:https://doaj.org/article/b8922c40f36d48b9a4bdddcab8658a90
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