Efficient homing of T cells via afferent lymphatics requires mechanical arrest and integrin-supported chemokine guidance

Immune cells mostly enter lymph nodes (LN) from blood circulation, but whether afferent lymphatics contributes to LN entry is unclear. Here, the authors show, using a photo-convertible reporter, that T cells in afferent lymphatics frequently enter LN and become arrested in the subcapsular sinus, wit...

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Autores principales:	Rieke Martens, Marc Permanyer, Kathrin Werth, Kai Yu, Asolina Braun, Olga Halle, Stephan Halle, Gwendolyn E. Patzer, Berislav Bošnjak, Friedemann Kiefer, Anika Janssen, Michaela Friedrichsen, Jenny Poetzsch, Karan Kohli, Yvonne Lueder, Rodrigo Gutierrez Jauregui, Nadine Eckert, Tim Worbs, Melanie Galla, Reinhold Förster
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b8963b2416da4786a23a0db5ee2b12ab
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spelling	oai:doaj.org-article:b8963b2416da4786a23a0db5ee2b12ab2021-12-02T16:50:04ZEfficient homing of T cells via afferent lymphatics requires mechanical arrest and integrin-supported chemokine guidance10.1038/s41467-020-14921-w2041-1723https://doaj.org/article/b8963b2416da4786a23a0db5ee2b12ab2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14921-whttps://doaj.org/toc/2041-1723Immune cells mostly enter lymph nodes (LN) from blood circulation, but whether afferent lymphatics contributes to LN entry is unclear. Here, the authors show, using a photo-convertible reporter, that T cells in afferent lymphatics frequently enter LN and become arrested in the subcapsular sinus, with chemokines and integrins further guiding their migration in the LN.Rieke MartensMarc PermanyerKathrin WerthKai YuAsolina BraunOlga HalleStephan HalleGwendolyn E. PatzerBerislav BošnjakFriedemann KieferAnika JanssenMichaela FriedrichsenJenny PoetzschKaran KohliYvonne LuederRodrigo Gutierrez JaureguiNadine EckertTim WorbsMelanie GallaReinhold FörsterNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rieke Martens Marc Permanyer Kathrin Werth Kai Yu Asolina Braun Olga Halle Stephan Halle Gwendolyn E. Patzer Berislav Bošnjak Friedemann Kiefer Anika Janssen Michaela Friedrichsen Jenny Poetzsch Karan Kohli Yvonne Lueder Rodrigo Gutierrez Jauregui Nadine Eckert Tim Worbs Melanie Galla Reinhold Förster Efficient homing of T cells via afferent lymphatics requires mechanical arrest and integrin-supported chemokine guidance
description	Immune cells mostly enter lymph nodes (LN) from blood circulation, but whether afferent lymphatics contributes to LN entry is unclear. Here, the authors show, using a photo-convertible reporter, that T cells in afferent lymphatics frequently enter LN and become arrested in the subcapsular sinus, with chemokines and integrins further guiding their migration in the LN.
format	article
author	Rieke Martens Marc Permanyer Kathrin Werth Kai Yu Asolina Braun Olga Halle Stephan Halle Gwendolyn E. Patzer Berislav Bošnjak Friedemann Kiefer Anika Janssen Michaela Friedrichsen Jenny Poetzsch Karan Kohli Yvonne Lueder Rodrigo Gutierrez Jauregui Nadine Eckert Tim Worbs Melanie Galla Reinhold Förster
author_facet	Rieke Martens Marc Permanyer Kathrin Werth Kai Yu Asolina Braun Olga Halle Stephan Halle Gwendolyn E. Patzer Berislav Bošnjak Friedemann Kiefer Anika Janssen Michaela Friedrichsen Jenny Poetzsch Karan Kohli Yvonne Lueder Rodrigo Gutierrez Jauregui Nadine Eckert Tim Worbs Melanie Galla Reinhold Förster
author_sort	Rieke Martens
title	Efficient homing of T cells via afferent lymphatics requires mechanical arrest and integrin-supported chemokine guidance
title_short	Efficient homing of T cells via afferent lymphatics requires mechanical arrest and integrin-supported chemokine guidance
title_full	Efficient homing of T cells via afferent lymphatics requires mechanical arrest and integrin-supported chemokine guidance
title_fullStr	Efficient homing of T cells via afferent lymphatics requires mechanical arrest and integrin-supported chemokine guidance
title_full_unstemmed	Efficient homing of T cells via afferent lymphatics requires mechanical arrest and integrin-supported chemokine guidance
title_sort	efficient homing of t cells via afferent lymphatics requires mechanical arrest and integrin-supported chemokine guidance
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b8963b2416da4786a23a0db5ee2b12ab
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Efficient homing of T cells via afferent lymphatics requires mechanical arrest and integrin-supported chemokine guidance

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