Programmed Cell Death Pathways in the Pathogenesis of Idiopathic Inflammatory Myopathies

Idiopathic inflammatory myopathy (IIM) is a heterogeneous group of acquired, autoimmune muscle diseases characterized by muscle inflammation and extramuscular involvements. Present literatures have revealed that dysregulated cell death in combination with impaired elimination of dead cells contribut...

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Autores principales:	Jia Shi, Mingwei Tang, Shuang Zhou, Dong Xu, Jiuliang Zhao, Chanyuan Wu, Qian Wang, Xinping Tian, Mengtao Li, Xiaofeng Zeng
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	idiopathic inflammatory myopathy (IIM) programmed cell death (PCD) apoptosis autophagy NETosis pyroptosis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/b89b1e1e8fc84f688b0cf7e3925affb4
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spelling	oai:doaj.org-article:b89b1e1e8fc84f688b0cf7e3925affb42021-11-30T17:23:07ZProgrammed Cell Death Pathways in the Pathogenesis of Idiopathic Inflammatory Myopathies1664-322410.3389/fimmu.2021.783616https://doaj.org/article/b89b1e1e8fc84f688b0cf7e3925affb42021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.783616/fullhttps://doaj.org/toc/1664-3224Idiopathic inflammatory myopathy (IIM) is a heterogeneous group of acquired, autoimmune muscle diseases characterized by muscle inflammation and extramuscular involvements. Present literatures have revealed that dysregulated cell death in combination with impaired elimination of dead cells contribute to the release of autoantigens, damage-associated molecular patterns (DAMPs) and inflammatory cytokines, and result in immune responses and tissue damages in autoimmune diseases, including IIMs. This review summarizes the roles of various forms of programmed cell death pathways in the pathogenesis of IIMs and provides evidence for potential therapeutic targets.Jia ShiJia ShiMingwei TangMingwei TangShuang ZhouShuang ZhouDong XuDong XuJiuliang ZhaoJiuliang ZhaoChanyuan WuChanyuan WuQian WangQian WangXinping TianXinping TianMengtao LiMengtao LiXiaofeng ZengXiaofeng ZengFrontiers Media S.A.articleidiopathic inflammatory myopathy (IIM)programmed cell death (PCD)apoptosisautophagyNETosispyroptosisImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	idiopathic inflammatory myopathy (IIM) programmed cell death (PCD) apoptosis autophagy NETosis pyroptosis Immunologic diseases. Allergy RC581-607
spellingShingle	idiopathic inflammatory myopathy (IIM) programmed cell death (PCD) apoptosis autophagy NETosis pyroptosis Immunologic diseases. Allergy RC581-607 Jia Shi Jia Shi Mingwei Tang Mingwei Tang Shuang Zhou Shuang Zhou Dong Xu Dong Xu Jiuliang Zhao Jiuliang Zhao Chanyuan Wu Chanyuan Wu Qian Wang Qian Wang Xinping Tian Xinping Tian Mengtao Li Mengtao Li Xiaofeng Zeng Xiaofeng Zeng Programmed Cell Death Pathways in the Pathogenesis of Idiopathic Inflammatory Myopathies
description	Idiopathic inflammatory myopathy (IIM) is a heterogeneous group of acquired, autoimmune muscle diseases characterized by muscle inflammation and extramuscular involvements. Present literatures have revealed that dysregulated cell death in combination with impaired elimination of dead cells contribute to the release of autoantigens, damage-associated molecular patterns (DAMPs) and inflammatory cytokines, and result in immune responses and tissue damages in autoimmune diseases, including IIMs. This review summarizes the roles of various forms of programmed cell death pathways in the pathogenesis of IIMs and provides evidence for potential therapeutic targets.
format	article
author	Jia Shi Jia Shi Mingwei Tang Mingwei Tang Shuang Zhou Shuang Zhou Dong Xu Dong Xu Jiuliang Zhao Jiuliang Zhao Chanyuan Wu Chanyuan Wu Qian Wang Qian Wang Xinping Tian Xinping Tian Mengtao Li Mengtao Li Xiaofeng Zeng Xiaofeng Zeng
author_facet	Jia Shi Jia Shi Mingwei Tang Mingwei Tang Shuang Zhou Shuang Zhou Dong Xu Dong Xu Jiuliang Zhao Jiuliang Zhao Chanyuan Wu Chanyuan Wu Qian Wang Qian Wang Xinping Tian Xinping Tian Mengtao Li Mengtao Li Xiaofeng Zeng Xiaofeng Zeng
author_sort	Jia Shi
title	Programmed Cell Death Pathways in the Pathogenesis of Idiopathic Inflammatory Myopathies
title_short	Programmed Cell Death Pathways in the Pathogenesis of Idiopathic Inflammatory Myopathies
title_full	Programmed Cell Death Pathways in the Pathogenesis of Idiopathic Inflammatory Myopathies
title_fullStr	Programmed Cell Death Pathways in the Pathogenesis of Idiopathic Inflammatory Myopathies
title_full_unstemmed	Programmed Cell Death Pathways in the Pathogenesis of Idiopathic Inflammatory Myopathies
title_sort	programmed cell death pathways in the pathogenesis of idiopathic inflammatory myopathies
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b89b1e1e8fc84f688b0cf7e3925affb4
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Programmed Cell Death Pathways in the Pathogenesis of Idiopathic Inflammatory Myopathies

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