Essentiality of fatty acid synthase in the 2D to anchorage-independent growth transition in transforming cells

The mechanisms associated with fatty acid synthase (FASN) upregulation during transformation are unclear. Here, the authors report that FASN promotes anaplerotic shift of the Krebs cycle in cancer cells expressing various oncogenes, and that its inhibition before transformation prevents tumour devel...

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Autores principales:	Maria J. Bueno, Veronica Jimenez-Renard, Sara Samino, Jordi Capellades, Alejandra Junza, María Luz López-Rodríguez, Javier Garcia-Carceles, Irene Lopez-Fabuel, Juan P. Bolaños, Navdeep S. Chandel, Oscar Yanes, Ramon Colomer, Miguel Quintela-Fandino
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b89dd0324e784e3382a7385377353baf
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spelling	oai:doaj.org-article:b89dd0324e784e3382a7385377353baf2021-12-02T17:01:44ZEssentiality of fatty acid synthase in the 2D to anchorage-independent growth transition in transforming cells10.1038/s41467-019-13028-12041-1723https://doaj.org/article/b89dd0324e784e3382a7385377353baf2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13028-1https://doaj.org/toc/2041-1723The mechanisms associated with fatty acid synthase (FASN) upregulation during transformation are unclear. Here, the authors report that FASN promotes anaplerotic shift of the Krebs cycle in cancer cells expressing various oncogenes, and that its inhibition before transformation prevents tumour development and invasion.Maria J. BuenoVeronica Jimenez-RenardSara SaminoJordi CapelladesAlejandra JunzaMaría Luz López-RodríguezJavier Garcia-CarcelesIrene Lopez-FabuelJuan P. BolañosNavdeep S. ChandelOscar YanesRamon ColomerMiguel Quintela-FandinoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maria J. Bueno Veronica Jimenez-Renard Sara Samino Jordi Capellades Alejandra Junza María Luz López-Rodríguez Javier Garcia-Carceles Irene Lopez-Fabuel Juan P. Bolaños Navdeep S. Chandel Oscar Yanes Ramon Colomer Miguel Quintela-Fandino Essentiality of fatty acid synthase in the 2D to anchorage-independent growth transition in transforming cells
description	The mechanisms associated with fatty acid synthase (FASN) upregulation during transformation are unclear. Here, the authors report that FASN promotes anaplerotic shift of the Krebs cycle in cancer cells expressing various oncogenes, and that its inhibition before transformation prevents tumour development and invasion.
format	article
author	Maria J. Bueno Veronica Jimenez-Renard Sara Samino Jordi Capellades Alejandra Junza María Luz López-Rodríguez Javier Garcia-Carceles Irene Lopez-Fabuel Juan P. Bolaños Navdeep S. Chandel Oscar Yanes Ramon Colomer Miguel Quintela-Fandino
author_facet	Maria J. Bueno Veronica Jimenez-Renard Sara Samino Jordi Capellades Alejandra Junza María Luz López-Rodríguez Javier Garcia-Carceles Irene Lopez-Fabuel Juan P. Bolaños Navdeep S. Chandel Oscar Yanes Ramon Colomer Miguel Quintela-Fandino
author_sort	Maria J. Bueno
title	Essentiality of fatty acid synthase in the 2D to anchorage-independent growth transition in transforming cells
title_short	Essentiality of fatty acid synthase in the 2D to anchorage-independent growth transition in transforming cells
title_full	Essentiality of fatty acid synthase in the 2D to anchorage-independent growth transition in transforming cells
title_fullStr	Essentiality of fatty acid synthase in the 2D to anchorage-independent growth transition in transforming cells
title_full_unstemmed	Essentiality of fatty acid synthase in the 2D to anchorage-independent growth transition in transforming cells
title_sort	essentiality of fatty acid synthase in the 2d to anchorage-independent growth transition in transforming cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b89dd0324e784e3382a7385377353baf
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Essentiality of fatty acid synthase in the 2D to anchorage-independent growth transition in transforming cells

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