Effects of a BMI1008 mixture on postoperative pain in a rat model of incisional pain.

<h4>Background</h4>The purpose of this study was to evaluate the analgesic effect of BMI1008 (a new drug containing lidocaine, methylene blue, dexamethasone and vitamin B complex) and to investigate the analgesic effect of lidocaine and BMI-L (other components of BMI1008 except lidocaine...

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Autores principales:	Geun Joo Choi, Eun Jin Ahn, Oh Haeng Lee, Hyun Kang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b89f25cf1df04c2cafe50ca9e3c18e81
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spelling	oai:doaj.org-article:b89f25cf1df04c2cafe50ca9e3c18e812021-12-02T20:06:09ZEffects of a BMI1008 mixture on postoperative pain in a rat model of incisional pain.1932-620310.1371/journal.pone.0257267https://doaj.org/article/b89f25cf1df04c2cafe50ca9e3c18e812021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257267https://doaj.org/toc/1932-6203<h4>Background</h4>The purpose of this study was to evaluate the analgesic effect of BMI1008 (a new drug containing lidocaine, methylene blue, dexamethasone and vitamin B complex) and to investigate the analgesic effect of lidocaine and BMI-L (other components of BMI1008 except lidocaine) at different concentrations in a rat model of incisional pain.<h4>Methods</h4>Male Sprague-Dawley rats (250-300 g) were used for the incisional pain model simulating postoperative pain. After the operation, normal saline, various concentrations of BMI1008, lidocaine with a fixed concentration of BMI-L, and BMI-L with a fixed concentration of lidocaine were injected at the incision site. The preventive analgesic effect was evaluated using BMI1008 administered 30 min before and immediately after the operation. In addition, BMI1008 was compared with positive controls using intraperitoneal ketorolac 30 mg/kg and fentanyl 0.5 μg/kg. The mechanical withdrawal threshold was measured with a von Frey filament.<h4>Results</h4>The analgesic effect according to the concentration of BMI1008, lidocaine with a fixed concentration of BMI-L, and BMI-L with a fixed concentration of lidocaine showed a concentration-dependent response and statistically significant difference among the groups (P <0.001, P <0.001, and P <0.001, respectively). The analgesic effect according to the time point of administration (before and after the operation) showed no evidence of a statistically significant difference between the groups (P = 0.170). Compared with the positive control groups, the results showed a statistically significant difference between the groups (P = 0.024).<h4>Conclusion</h4>BMI1008 showed its analgesic effect in a rat model of incisional pain in a concentration-dependent manner. Moreover, BMI-L showed an additive effect on the analgesic effect of lidocaine.Geun Joo ChoiEun Jin AhnOh Haeng LeeHyun KangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257267 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Geun Joo Choi Eun Jin Ahn Oh Haeng Lee Hyun Kang Effects of a BMI1008 mixture on postoperative pain in a rat model of incisional pain.
description	<h4>Background</h4>The purpose of this study was to evaluate the analgesic effect of BMI1008 (a new drug containing lidocaine, methylene blue, dexamethasone and vitamin B complex) and to investigate the analgesic effect of lidocaine and BMI-L (other components of BMI1008 except lidocaine) at different concentrations in a rat model of incisional pain.<h4>Methods</h4>Male Sprague-Dawley rats (250-300 g) were used for the incisional pain model simulating postoperative pain. After the operation, normal saline, various concentrations of BMI1008, lidocaine with a fixed concentration of BMI-L, and BMI-L with a fixed concentration of lidocaine were injected at the incision site. The preventive analgesic effect was evaluated using BMI1008 administered 30 min before and immediately after the operation. In addition, BMI1008 was compared with positive controls using intraperitoneal ketorolac 30 mg/kg and fentanyl 0.5 μg/kg. The mechanical withdrawal threshold was measured with a von Frey filament.<h4>Results</h4>The analgesic effect according to the concentration of BMI1008, lidocaine with a fixed concentration of BMI-L, and BMI-L with a fixed concentration of lidocaine showed a concentration-dependent response and statistically significant difference among the groups (P <0.001, P <0.001, and P <0.001, respectively). The analgesic effect according to the time point of administration (before and after the operation) showed no evidence of a statistically significant difference between the groups (P = 0.170). Compared with the positive control groups, the results showed a statistically significant difference between the groups (P = 0.024).<h4>Conclusion</h4>BMI1008 showed its analgesic effect in a rat model of incisional pain in a concentration-dependent manner. Moreover, BMI-L showed an additive effect on the analgesic effect of lidocaine.
format	article
author	Geun Joo Choi Eun Jin Ahn Oh Haeng Lee Hyun Kang
author_facet	Geun Joo Choi Eun Jin Ahn Oh Haeng Lee Hyun Kang
author_sort	Geun Joo Choi
title	Effects of a BMI1008 mixture on postoperative pain in a rat model of incisional pain.
title_short	Effects of a BMI1008 mixture on postoperative pain in a rat model of incisional pain.
title_full	Effects of a BMI1008 mixture on postoperative pain in a rat model of incisional pain.
title_fullStr	Effects of a BMI1008 mixture on postoperative pain in a rat model of incisional pain.
title_full_unstemmed	Effects of a BMI1008 mixture on postoperative pain in a rat model of incisional pain.
title_sort	effects of a bmi1008 mixture on postoperative pain in a rat model of incisional pain.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/b89f25cf1df04c2cafe50ca9e3c18e81
work_keys_str_mv	AT geunjoochoi effectsofabmi1008mixtureonpostoperativepaininaratmodelofincisionalpain AT eunjinahn effectsofabmi1008mixtureonpostoperativepaininaratmodelofincisionalpain AT ohhaenglee effectsofabmi1008mixtureonpostoperativepaininaratmodelofincisionalpain AT hyunkang effectsofabmi1008mixtureonpostoperativepaininaratmodelofincisionalpain
_version_	1718375445572878336

Effects of a BMI1008 mixture on postoperative pain in a rat model of incisional pain.

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