A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes

A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes

Vaccines that interrupt malaria transmission will be important tools for malaria elimination. Here the authors identify a human monoclonal antibody from Pfs230 vaccinated individuals that blocks transmission of Plasmodium falciparum to mosquitoes in a complement-dependent manner and reacts with game...

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Autores principales: Camila H. Coelho, Wai Kwan Tang, Martin Burkhardt, Jacob D. Galson, Olga Muratova, Nichole D. Salinas, Thiago Luiz Alves e Silva, Karine Reiter, Nicholas J. MacDonald, Vu Nguyen, Raul Herrera, Richard Shimp, David L. Narum, Miranda Byrne-Steele, Wenjing Pan, Xiaohong Hou, Brittany Brown, Mary Eisenhower, Jian Han, Bethany J. Jenkins, Justin Y. A. Doritchamou, Margery G. Smelkinson, Joel Vega-Rodríguez, Johannes Trück, Justin J. Taylor, Issaka Sagara, Jonathan P. Renn, Niraj H. Tolia, Patrick E. Duffy
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/b8a08c9111ab413faed46691e94e1923
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spelling oai:doaj.org-article:b8a08c9111ab413faed46691e94e19232021-12-02T13:17:39ZA human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes10.1038/s41467-021-21955-12041-1723https://doaj.org/article/b8a08c9111ab413faed46691e94e19232021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21955-1https://doaj.org/toc/2041-1723Vaccines that interrupt malaria transmission will be important tools for malaria elimination. Here the authors identify a human monoclonal antibody from Pfs230 vaccinated individuals that blocks transmission of Plasmodium falciparum to mosquitoes in a complement-dependent manner and reacts with gamete surface.Camila H. CoelhoWai Kwan TangMartin BurkhardtJacob D. GalsonOlga MuratovaNichole D. SalinasThiago Luiz Alves e SilvaKarine ReiterNicholas J. MacDonaldVu NguyenRaul HerreraRichard ShimpDavid L. NarumMiranda Byrne-SteeleWenjing PanXiaohong HouBrittany BrownMary EisenhowerJian HanBethany J. JenkinsJustin Y. A. DoritchamouMargery G. SmelkinsonJoel Vega-RodríguezJohannes TrückJustin J. TaylorIssaka SagaraJonathan P. RennNiraj H. ToliaPatrick E. DuffyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Camila H. Coelho
Wai Kwan Tang
Martin Burkhardt
Jacob D. Galson
Olga Muratova
Nichole D. Salinas
Thiago Luiz Alves e Silva
Karine Reiter
Nicholas J. MacDonald
Vu Nguyen
Raul Herrera
Richard Shimp
David L. Narum
Miranda Byrne-Steele
Wenjing Pan
Xiaohong Hou
Brittany Brown
Mary Eisenhower
Jian Han
Bethany J. Jenkins
Justin Y. A. Doritchamou
Margery G. Smelkinson
Joel Vega-Rodríguez
Johannes Trück
Justin J. Taylor
Issaka Sagara
Jonathan P. Renn
Niraj H. Tolia
Patrick E. Duffy
A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes
description Vaccines that interrupt malaria transmission will be important tools for malaria elimination. Here the authors identify a human monoclonal antibody from Pfs230 vaccinated individuals that blocks transmission of Plasmodium falciparum to mosquitoes in a complement-dependent manner and reacts with gamete surface.
format article
author Camila H. Coelho
Wai Kwan Tang
Martin Burkhardt
Jacob D. Galson
Olga Muratova
Nichole D. Salinas
Thiago Luiz Alves e Silva
Karine Reiter
Nicholas J. MacDonald
Vu Nguyen
Raul Herrera
Richard Shimp
David L. Narum
Miranda Byrne-Steele
Wenjing Pan
Xiaohong Hou
Brittany Brown
Mary Eisenhower
Jian Han
Bethany J. Jenkins
Justin Y. A. Doritchamou
Margery G. Smelkinson
Joel Vega-Rodríguez
Johannes Trück
Justin J. Taylor
Issaka Sagara
Jonathan P. Renn
Niraj H. Tolia
Patrick E. Duffy
author_facet Camila H. Coelho
Wai Kwan Tang
Martin Burkhardt
Jacob D. Galson
Olga Muratova
Nichole D. Salinas
Thiago Luiz Alves e Silva
Karine Reiter
Nicholas J. MacDonald
Vu Nguyen
Raul Herrera
Richard Shimp
David L. Narum
Miranda Byrne-Steele
Wenjing Pan
Xiaohong Hou
Brittany Brown
Mary Eisenhower
Jian Han
Bethany J. Jenkins
Justin Y. A. Doritchamou
Margery G. Smelkinson
Joel Vega-Rodríguez
Johannes Trück
Justin J. Taylor
Issaka Sagara
Jonathan P. Renn
Niraj H. Tolia
Patrick E. Duffy
author_sort Camila H. Coelho
title A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes
title_short A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes
title_full A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes
title_fullStr A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes
title_full_unstemmed A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes
title_sort human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/b8a08c9111ab413faed46691e94e1923
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