Direct, acute effects of Klotho and FGF23 on vascular smooth muscle and endothelium.

Direct, acute effects of Klotho and FGF23 on vascular smooth muscle and endothelium.

Chronic kidney disease (CKD) is regarded as a state of Klotho deficiency and FGF23 excess. In patients with CKD a strong association has been found between increased serum FGF23 and mortality risk, possibly via enhanced atherosclerosis, vascular stiffness, and vascular calcification. The aim of this...

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Autores principales: Isabelle Six, Hirokazu Okazaki, Priscilla Gross, Joanna Cagnard, Cédric Boudot, Julien Maizel, Tilman B Drueke, Ziad A Massy
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/b8a343182f2e4adab29034359c701ffb
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