Altered spontaneous brain activity patterns in patients with unilateral acute open globe injury using amplitude of low-frequency fluctuation: a functional magnetic resonance imaging study

Gang Tan,1,2,* Xin Huang,1,3,* Lei Ye,1 An-Hua Wu,2 Li-Xian He,2 Yu-Lin Zhong,1 Nan Jiang,1 Fu-Qing Zhou,4 Yi Shao1 1Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 2Department of Ophthalmology, The First Affiliated Hospital of University of Sou...

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Autores principales:	Tan G, Huang X, Ye L, Wu AH, He LX, Zhong YL, Jiang N, Zhou FQ, Shao Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	ALFF open globe injury resting state spontaneous activity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/b8a8f31e266a4cbf97b27f90476bceba
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spelling	oai:doaj.org-article:b8a8f31e266a4cbf97b27f90476bceba2021-12-02T02:39:03ZAltered spontaneous brain activity patterns in patients with unilateral acute open globe injury using amplitude of low-frequency fluctuation: a functional magnetic resonance imaging study1178-2021https://doaj.org/article/b8a8f31e266a4cbf97b27f90476bceba2016-08-01T00:00:00Zhttps://www.dovepress.com/altered-spontaneous-brain-activity-patterns-in-patients-with-unilatera-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Gang Tan,1,2,* Xin Huang,1,3,* Lei Ye,1 An-Hua Wu,2 Li-Xian He,2 Yu-Lin Zhong,1 Nan Jiang,1 Fu-Qing Zhou,4 Yi Shao1 1Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 2Department of Ophthalmology, The First Affiliated Hospital of University of South China, Hengyang, Hunan, 3Department of Ophthalmology, The First People’s Hospital of Jiujiang City, Jiujiang, 4Department of Radiology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Medical Imaging Research Institute, Nanchang, Jiangxi, People’s Republic of China *These authors contributed equally to this work Objective: The aim of this study was to evaluate altered spontaneous brain activities in patients with unilateral acute open globe injury (OGI) using amplitude of low-frequency fluctuation (ALFF) method and its relationship with their clinical manifestations.Patients and methods: A total of 18 patients with acute OGI (16 males and two females) and 18 healthy controls (HCs, 16 males and two females) closely matched in age, sex, and education were recruited in this study. The ALFF method was used to evaluate the altered spontaneous brain activities. The relationships between the mean ALFF signal values of different brain regions and the clinical features were evaluated by correlation analysis. Acute OGI patients were distinguished from HCs by receiver operating characteristic curve.Results: Compared with HCs, acute OGI patients had significantly higher ALFF values in the left cuneus, left middle cingulum cortex, and bilateral precuneus. Furthermore, the age of OGI patients showed a negative correlation with the ALFF signal value of the left middle cingulum cortex (r=-0.557, P=0.016) and a negative correlation with the mean ALFF signal value of the bilateral precuneus (r=-0.746, P<0.001). The ALFF signal value of the bilateral precuneus was negatively correlated with the duration of OGI (r=-0.493, P=0.038) and positively correlated with the vision acuity of the injured eye (r=0.583, P=0.011).Conclusion: Acute OGI mainly induces dysfunction in the left cuneus, left middle cingulum cortex, and bilateral precuneus, which may reflect the underlying pathologic mechanisms of abnormal brain activities in OGI patients. Keywords: ALFF, open globe injury, resting state, spontaneous activity, magnetic resonance imaging Tan GHuang XYe LWu AHHe LXZhong YLJiang NZhou FQShao YDove Medical PressarticleALFFopen globe injuryresting statespontaneous activityNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 2015-2020 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	ALFF open globe injury resting state spontaneous activity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	ALFF open globe injury resting state spontaneous activity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Tan G Huang X Ye L Wu AH He LX Zhong YL Jiang N Zhou FQ Shao Y Altered spontaneous brain activity patterns in patients with unilateral acute open globe injury using amplitude of low-frequency fluctuation: a functional magnetic resonance imaging study
description	Gang Tan,1,2,* Xin Huang,1,3,* Lei Ye,1 An-Hua Wu,2 Li-Xian He,2 Yu-Lin Zhong,1 Nan Jiang,1 Fu-Qing Zhou,4 Yi Shao1 1Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 2Department of Ophthalmology, The First Affiliated Hospital of University of South China, Hengyang, Hunan, 3Department of Ophthalmology, The First People’s Hospital of Jiujiang City, Jiujiang, 4Department of Radiology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Medical Imaging Research Institute, Nanchang, Jiangxi, People’s Republic of China *These authors contributed equally to this work Objective: The aim of this study was to evaluate altered spontaneous brain activities in patients with unilateral acute open globe injury (OGI) using amplitude of low-frequency fluctuation (ALFF) method and its relationship with their clinical manifestations.Patients and methods: A total of 18 patients with acute OGI (16 males and two females) and 18 healthy controls (HCs, 16 males and two females) closely matched in age, sex, and education were recruited in this study. The ALFF method was used to evaluate the altered spontaneous brain activities. The relationships between the mean ALFF signal values of different brain regions and the clinical features were evaluated by correlation analysis. Acute OGI patients were distinguished from HCs by receiver operating characteristic curve.Results: Compared with HCs, acute OGI patients had significantly higher ALFF values in the left cuneus, left middle cingulum cortex, and bilateral precuneus. Furthermore, the age of OGI patients showed a negative correlation with the ALFF signal value of the left middle cingulum cortex (r=-0.557, P=0.016) and a negative correlation with the mean ALFF signal value of the bilateral precuneus (r=-0.746, P<0.001). The ALFF signal value of the bilateral precuneus was negatively correlated with the duration of OGI (r=-0.493, P=0.038) and positively correlated with the vision acuity of the injured eye (r=0.583, P=0.011).Conclusion: Acute OGI mainly induces dysfunction in the left cuneus, left middle cingulum cortex, and bilateral precuneus, which may reflect the underlying pathologic mechanisms of abnormal brain activities in OGI patients. Keywords: ALFF, open globe injury, resting state, spontaneous activity, magnetic resonance imaging
format	article
author	Tan G Huang X Ye L Wu AH He LX Zhong YL Jiang N Zhou FQ Shao Y
author_facet	Tan G Huang X Ye L Wu AH He LX Zhong YL Jiang N Zhou FQ Shao Y
author_sort	Tan G
title	Altered spontaneous brain activity patterns in patients with unilateral acute open globe injury using amplitude of low-frequency fluctuation: a functional magnetic resonance imaging study
title_short	Altered spontaneous brain activity patterns in patients with unilateral acute open globe injury using amplitude of low-frequency fluctuation: a functional magnetic resonance imaging study
title_full	Altered spontaneous brain activity patterns in patients with unilateral acute open globe injury using amplitude of low-frequency fluctuation: a functional magnetic resonance imaging study
title_fullStr	Altered spontaneous brain activity patterns in patients with unilateral acute open globe injury using amplitude of low-frequency fluctuation: a functional magnetic resonance imaging study
title_full_unstemmed	Altered spontaneous brain activity patterns in patients with unilateral acute open globe injury using amplitude of low-frequency fluctuation: a functional magnetic resonance imaging study
title_sort	altered spontaneous brain activity patterns in patients with unilateral acute open globe injury using amplitude of low-frequency fluctuation: a functional magnetic resonance imaging study
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/b8a8f31e266a4cbf97b27f90476bceba
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Altered spontaneous brain activity patterns in patients with unilateral acute open globe injury using amplitude of low-frequency fluctuation: a functional magnetic resonance imaging study

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