Adding a low-concentration sciatic nerve block to total knee arthroplasty in patients susceptible to the adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs): a randomized controlled trial

Abstract Background This study compared the effects of adductor canal blocks with those of a low concentration of popliteal-sciatic nerve block (SNB) and dexamethasone as an adjunctive technique for total knee arthroplasties (TKA) in patients susceptible to the adverse effects of NSAIDs. Methods A p...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Busara Sirivanasandha, Kulwadee Sutthivaiyakit, Thippatai Kerdchan, Suppachai Poolsuppasit, Suwimon Tangwiwat, Pathom Halilamien
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Adverse effects of NSAIDs Popliteal-sciatic nerve block (SNB) Dexamethasone Total knee arthroplasty (TKA) Adductor canal blocks Pain management Anesthesiology RD78.3-87.3
Acceso en línea:	https://doaj.org/article/b8a9f0d6b57b4f0fba4eb4140212e941
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b8a9f0d6b57b4f0fba4eb4140212e941
record_format	dspace
spelling	oai:doaj.org-article:b8a9f0d6b57b4f0fba4eb4140212e9412021-11-14T12:11:44ZAdding a low-concentration sciatic nerve block to total knee arthroplasty in patients susceptible to the adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs): a randomized controlled trial10.1186/s12871-021-01491-71471-2253https://doaj.org/article/b8a9f0d6b57b4f0fba4eb4140212e9412021-11-01T00:00:00Zhttps://doi.org/10.1186/s12871-021-01491-7https://doaj.org/toc/1471-2253Abstract Background This study compared the effects of adductor canal blocks with those of a low concentration of popliteal-sciatic nerve block (SNB) and dexamethasone as an adjunctive technique for total knee arthroplasties (TKA) in patients susceptible to the adverse effects of NSAIDs. Methods A prospective, double-blinded, randomized controlled trial was performed in 50 patients susceptible to the adverse effects of NSAIDs undergoing unilateral TKAs. All patients received spinal anesthesia, adductor canal blocks, and periarticular infiltration. The 25 patients in the intervention group received SNB (0.125% bupivacaine [20 ml] and dexamethasone [5 mg]). Results The SNB group significantly had lower median resting pain scores at 6, 12, and 18 h: the control group, 1 (0–4.5), 3 (0–5), and 3 (2–5); the intervention group, 0 (0–0), 0 (0–3), and 1 (0–3); p-values, 0.012, 0.021, and 0.010, respectively. Movement-evoked pain scores at 6, 12, and 18 h were also lower: control group, 3 (0–5.5), 5 (2.5–6.5), and 7 (4–9); intervention group, 0 (0–1.5), 2 (0–4), and 3 (2–5); p-values, 0.019, 0.005, and 0.001, respectively. There were no differences in motor function. Moreover, the mean morphine consumption 24 h was also reduced in the SNB group: control group, 3.80 ± 2.48 mg; intervention group, 1.96 ± 2 mg; p-value, 0.005. Conclusion For patients susceptible to the adverse effects of NSAIDs, a low concentration of SNB and dexamethasone is an effective adjunctive technique for early postoperative pain control (especially on movement) following TKAs, without an increase in motor weakness. Trial registration ClinicalTrials.gov , NCT03486548 , Registered 3 April 2018.Busara SirivanasandhaKulwadee SutthivaiyakitThippatai KerdchanSuppachai PoolsuppasitSuwimon TangwiwatPathom HalilamienBMCarticleAdverse effects of NSAIDsPopliteal-sciatic nerve block (SNB)DexamethasoneTotal knee arthroplasty (TKA)Adductor canal blocksPain managementAnesthesiologyRD78.3-87.3ENBMC Anesthesiology, Vol 21, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Adverse effects of NSAIDs Popliteal-sciatic nerve block (SNB) Dexamethasone Total knee arthroplasty (TKA) Adductor canal blocks Pain management Anesthesiology RD78.3-87.3
spellingShingle	Adverse effects of NSAIDs Popliteal-sciatic nerve block (SNB) Dexamethasone Total knee arthroplasty (TKA) Adductor canal blocks Pain management Anesthesiology RD78.3-87.3 Busara Sirivanasandha Kulwadee Sutthivaiyakit Thippatai Kerdchan Suppachai Poolsuppasit Suwimon Tangwiwat Pathom Halilamien Adding a low-concentration sciatic nerve block to total knee arthroplasty in patients susceptible to the adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs): a randomized controlled trial
description	Abstract Background This study compared the effects of adductor canal blocks with those of a low concentration of popliteal-sciatic nerve block (SNB) and dexamethasone as an adjunctive technique for total knee arthroplasties (TKA) in patients susceptible to the adverse effects of NSAIDs. Methods A prospective, double-blinded, randomized controlled trial was performed in 50 patients susceptible to the adverse effects of NSAIDs undergoing unilateral TKAs. All patients received spinal anesthesia, adductor canal blocks, and periarticular infiltration. The 25 patients in the intervention group received SNB (0.125% bupivacaine [20 ml] and dexamethasone [5 mg]). Results The SNB group significantly had lower median resting pain scores at 6, 12, and 18 h: the control group, 1 (0–4.5), 3 (0–5), and 3 (2–5); the intervention group, 0 (0–0), 0 (0–3), and 1 (0–3); p-values, 0.012, 0.021, and 0.010, respectively. Movement-evoked pain scores at 6, 12, and 18 h were also lower: control group, 3 (0–5.5), 5 (2.5–6.5), and 7 (4–9); intervention group, 0 (0–1.5), 2 (0–4), and 3 (2–5); p-values, 0.019, 0.005, and 0.001, respectively. There were no differences in motor function. Moreover, the mean morphine consumption 24 h was also reduced in the SNB group: control group, 3.80 ± 2.48 mg; intervention group, 1.96 ± 2 mg; p-value, 0.005. Conclusion For patients susceptible to the adverse effects of NSAIDs, a low concentration of SNB and dexamethasone is an effective adjunctive technique for early postoperative pain control (especially on movement) following TKAs, without an increase in motor weakness. Trial registration ClinicalTrials.gov , NCT03486548 , Registered 3 April 2018.
format	article
author	Busara Sirivanasandha Kulwadee Sutthivaiyakit Thippatai Kerdchan Suppachai Poolsuppasit Suwimon Tangwiwat Pathom Halilamien
author_facet	Busara Sirivanasandha Kulwadee Sutthivaiyakit Thippatai Kerdchan Suppachai Poolsuppasit Suwimon Tangwiwat Pathom Halilamien
author_sort	Busara Sirivanasandha
title	Adding a low-concentration sciatic nerve block to total knee arthroplasty in patients susceptible to the adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs): a randomized controlled trial
title_short	Adding a low-concentration sciatic nerve block to total knee arthroplasty in patients susceptible to the adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs): a randomized controlled trial
title_full	Adding a low-concentration sciatic nerve block to total knee arthroplasty in patients susceptible to the adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs): a randomized controlled trial
title_fullStr	Adding a low-concentration sciatic nerve block to total knee arthroplasty in patients susceptible to the adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs): a randomized controlled trial
title_full_unstemmed	Adding a low-concentration sciatic nerve block to total knee arthroplasty in patients susceptible to the adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs): a randomized controlled trial
title_sort	adding a low-concentration sciatic nerve block to total knee arthroplasty in patients susceptible to the adverse effects of non-steroidal anti-inflammatory drugs (nsaids): a randomized controlled trial
publisher	BMC
publishDate	2021
url	https://doaj.org/article/b8a9f0d6b57b4f0fba4eb4140212e941
work_keys_str_mv	AT busarasirivanasandha addingalowconcentrationsciaticnerveblocktototalkneearthroplastyinpatientssusceptibletotheadverseeffectsofnonsteroidalantiinflammatorydrugsnsaidsarandomizedcontrolledtrial AT kulwadeesutthivaiyakit addingalowconcentrationsciaticnerveblocktototalkneearthroplastyinpatientssusceptibletotheadverseeffectsofnonsteroidalantiinflammatorydrugsnsaidsarandomizedcontrolledtrial AT thippataikerdchan addingalowconcentrationsciaticnerveblocktototalkneearthroplastyinpatientssusceptibletotheadverseeffectsofnonsteroidalantiinflammatorydrugsnsaidsarandomizedcontrolledtrial AT suppachaipoolsuppasit addingalowconcentrationsciaticnerveblocktototalkneearthroplastyinpatientssusceptibletotheadverseeffectsofnonsteroidalantiinflammatorydrugsnsaidsarandomizedcontrolledtrial AT suwimontangwiwat addingalowconcentrationsciaticnerveblocktototalkneearthroplastyinpatientssusceptibletotheadverseeffectsofnonsteroidalantiinflammatorydrugsnsaidsarandomizedcontrolledtrial AT pathomhalilamien addingalowconcentrationsciaticnerveblocktototalkneearthroplastyinpatientssusceptibletotheadverseeffectsofnonsteroidalantiinflammatorydrugsnsaidsarandomizedcontrolledtrial
_version_	1718429427354828800

Adding a low-concentration sciatic nerve block to total knee arthroplasty in patients susceptible to the adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs): a randomized controlled trial

Ejemplares similares