TwinCons: Conservation score for uncovering deep sequence similarity and divergence.

We have developed the program TwinCons, to detect noisy signals of deep ancestry of proteins or nucleic acids. As input, the program uses a composite alignment containing pre-defined groups, and mathematically determines a 'cost' of transforming one group to the other at each position of t...

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Bibliographic Details
Main Authors: Petar I Penev, Claudia Alvarez-Carreño, Eric Smith, Anton S Petrov, Loren Dean Williams
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2021
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Online Access:https://doaj.org/article/b8aec4db844f4ec1adda39cb98b36cd8
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