ADRENERGIC REGULATION OF IMMUNE RESPONSE UNDER EXPERIMENTAL THYROTOXICOSIS IN RATS

It was established that a changes of antibody production and reaction of delayed—type hypersensitivity at the local immune response to thymus-dependent antigen were opposite in rats with varying severity of experimental thyrotoxicosis — stimulation under a mild form of thyrotoxicosis and depression...

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Autores principales:	Ju. I. Shilov, A. P. Godovalov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2012
Materias:	experimental thyrotoxicosis adrenoceptors the immune response Science Q
Acceso en línea:	https://doaj.org/article/b8b0f68f48234d7a9c4d0605da17e999
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spelling	oai:doaj.org-article:b8b0f68f48234d7a9c4d0605da17e9992021-11-23T06:14:20ZADRENERGIC REGULATION OF IMMUNE RESPONSE UNDER EXPERIMENTAL THYROTOXICOSIS IN RATS2541-94202587-9596https://doaj.org/article/b8b0f68f48234d7a9c4d0605da17e9992012-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/950https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596It was established that a changes of antibody production and reaction of delayed—type hypersensitivity at the local immune response to thymus-dependent antigen were opposite in rats with varying severity of experimental thyrotoxicosis — stimulation under a mild form of thyrotoxicosis and depression under more severe form. The increase in glucocorticoid level may be involved in the mechanism of immunosuppression under severe form thyrotoxicosis. The administration of agonist or antagonist of beta-adrenoceptors to animals with thyrotoxicosis led to the significant modification of changes of an immune response parameters, that confirms the participation of an increase in the sensitivity to beta-adrenergic regulation of immune system cells in immunomodulation under thyrotoxicosis.Ju. I. ShilovA. P. GodovalovScientific Сentre for Family Health and Human Reproduction Problemsarticleexperimental thyrotoxicosisadrenoceptorsthe immune responseScienceQRUActa Biomedica Scientifica, Vol 0, Iss 3(2), Pp 348-354 (2012)
institution	DOAJ
collection	DOAJ
language	RU
topic	experimental thyrotoxicosis adrenoceptors the immune response Science Q
spellingShingle	experimental thyrotoxicosis adrenoceptors the immune response Science Q Ju. I. Shilov A. P. Godovalov ADRENERGIC REGULATION OF IMMUNE RESPONSE UNDER EXPERIMENTAL THYROTOXICOSIS IN RATS
description	It was established that a changes of antibody production and reaction of delayed—type hypersensitivity at the local immune response to thymus-dependent antigen were opposite in rats with varying severity of experimental thyrotoxicosis — stimulation under a mild form of thyrotoxicosis and depression under more severe form. The increase in glucocorticoid level may be involved in the mechanism of immunosuppression under severe form thyrotoxicosis. The administration of agonist or antagonist of beta-adrenoceptors to animals with thyrotoxicosis led to the significant modification of changes of an immune response parameters, that confirms the participation of an increase in the sensitivity to beta-adrenergic regulation of immune system cells in immunomodulation under thyrotoxicosis.
format	article
author	Ju. I. Shilov A. P. Godovalov
author_facet	Ju. I. Shilov A. P. Godovalov
author_sort	Ju. I. Shilov
title	ADRENERGIC REGULATION OF IMMUNE RESPONSE UNDER EXPERIMENTAL THYROTOXICOSIS IN RATS
title_short	ADRENERGIC REGULATION OF IMMUNE RESPONSE UNDER EXPERIMENTAL THYROTOXICOSIS IN RATS
title_full	ADRENERGIC REGULATION OF IMMUNE RESPONSE UNDER EXPERIMENTAL THYROTOXICOSIS IN RATS
title_fullStr	ADRENERGIC REGULATION OF IMMUNE RESPONSE UNDER EXPERIMENTAL THYROTOXICOSIS IN RATS
title_full_unstemmed	ADRENERGIC REGULATION OF IMMUNE RESPONSE UNDER EXPERIMENTAL THYROTOXICOSIS IN RATS
title_sort	adrenergic regulation of immune response under experimental thyrotoxicosis in rats
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2012
url	https://doaj.org/article/b8b0f68f48234d7a9c4d0605da17e999
work_keys_str_mv	AT juishilov adrenergicregulationofimmuneresponseunderexperimentalthyrotoxicosisinrats AT apgodovalov adrenergicregulationofimmuneresponseunderexperimentalthyrotoxicosisinrats
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ADRENERGIC REGULATION OF IMMUNE RESPONSE UNDER EXPERIMENTAL THYROTOXICOSIS IN RATS

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