Shift from stochastic to spatially-ordered expression of serine-glycine synthesis enzymes in 3D microtumors

Abstract Cell-to-cell differences in protein expression in normal tissues and tumors are a common phenomenon, but the underlying principles that govern this heterogeneity are largely unknown. Here, we show that in monolayer cancer cell-line cultures, the expression of the five metabolic enzymes of s...

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Autores principales: Manjulata Singh, Katsuhiko Warita, Tomoko Warita, James R. Faeder, Robin E. C. Lee, Shilpa Sant, Zoltán N. Oltvai
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/b8b1173131934a50bf33d3f5f39499ac
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