Novel circular RNA circATRNL1 accelerates the osteosarcoma aerobic glycolysis through targeting miR-409-3p/LDHA

In recent researches, circular RNAs (circRNAs) have been shown to exert critical functions in osteosarcoma biology. Nevertheless, the contribution of circRNAs to osteosarcoma remains largely unclear. Results indicated that expression of circATRNL1 was higher in osteosarcoma tissues and cells. The hi...

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Auteurs principaux:	Quanbin Zhang, Lina Wang, Lili Cao, Tao Wei
Format:	article
Langue:	EN
Publié:	Taylor & Francis Group 2021
Sujets:	osteosarcoma circular rna circatrnl1 aerobic glycolysis ldha Biotechnology TP248.13-248.65
Accès en ligne:	https://doaj.org/article/b8b6e232cb834dbe8b8189a185c3db96
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spelling	oai:doaj.org-article:b8b6e232cb834dbe8b8189a185c3db962021-12-01T14:41:00ZNovel circular RNA circATRNL1 accelerates the osteosarcoma aerobic glycolysis through targeting miR-409-3p/LDHA2165-59792165-598710.1080/21655979.2021.1985343https://doaj.org/article/b8b6e232cb834dbe8b8189a185c3db962021-12-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.1985343https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987In recent researches, circular RNAs (circRNAs) have been shown to exert critical functions in osteosarcoma biology. Nevertheless, the contribution of circRNAs to osteosarcoma remains largely unclear. Results indicated that expression of circATRNL1 was higher in osteosarcoma tissues and cells. The high-expression of circATRNL1 was significantly correlated with aggressive features and acted as an independent risk factor for osteosarcoma patients’ overall survival. Functionally, our findings demonstrate that circATRNL1 promotes the osteosarcoma aerobic glycolysis in vitro. Mechanistically, circATRNL1 up-regulated the expression level of LDHA, which was also targeted by miR-409-3p. Therefore, circATRNL1 exerted the accelerative roles of osteosarcoma aerobic glycolysis through miR-409-3p/LDHA axis. In conclusion, circATRNL1 promoted osteosarcoma progression by enhancing glycolysis via circATRNL1/miR-409-3p/LDHA axis, which may inspire a novel therapeutic target for osteosarcoma.Quanbin ZhangLina WangLili CaoTao WeiTaylor & Francis Grouparticleosteosarcomacircular rnacircatrnl1aerobic glycolysisldhaBiotechnologyTP248.13-248.65ENBioengineered, Vol 12, Iss 2, Pp 9965-9975 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	osteosarcoma circular rna circatrnl1 aerobic glycolysis ldha Biotechnology TP248.13-248.65
spellingShingle	osteosarcoma circular rna circatrnl1 aerobic glycolysis ldha Biotechnology TP248.13-248.65 Quanbin Zhang Lina Wang Lili Cao Tao Wei Novel circular RNA circATRNL1 accelerates the osteosarcoma aerobic glycolysis through targeting miR-409-3p/LDHA
description	In recent researches, circular RNAs (circRNAs) have been shown to exert critical functions in osteosarcoma biology. Nevertheless, the contribution of circRNAs to osteosarcoma remains largely unclear. Results indicated that expression of circATRNL1 was higher in osteosarcoma tissues and cells. The high-expression of circATRNL1 was significantly correlated with aggressive features and acted as an independent risk factor for osteosarcoma patients’ overall survival. Functionally, our findings demonstrate that circATRNL1 promotes the osteosarcoma aerobic glycolysis in vitro. Mechanistically, circATRNL1 up-regulated the expression level of LDHA, which was also targeted by miR-409-3p. Therefore, circATRNL1 exerted the accelerative roles of osteosarcoma aerobic glycolysis through miR-409-3p/LDHA axis. In conclusion, circATRNL1 promoted osteosarcoma progression by enhancing glycolysis via circATRNL1/miR-409-3p/LDHA axis, which may inspire a novel therapeutic target for osteosarcoma.
format	article
author	Quanbin Zhang Lina Wang Lili Cao Tao Wei
author_facet	Quanbin Zhang Lina Wang Lili Cao Tao Wei
author_sort	Quanbin Zhang
title	Novel circular RNA circATRNL1 accelerates the osteosarcoma aerobic glycolysis through targeting miR-409-3p/LDHA
title_short	Novel circular RNA circATRNL1 accelerates the osteosarcoma aerobic glycolysis through targeting miR-409-3p/LDHA
title_full	Novel circular RNA circATRNL1 accelerates the osteosarcoma aerobic glycolysis through targeting miR-409-3p/LDHA
title_fullStr	Novel circular RNA circATRNL1 accelerates the osteosarcoma aerobic glycolysis through targeting miR-409-3p/LDHA
title_full_unstemmed	Novel circular RNA circATRNL1 accelerates the osteosarcoma aerobic glycolysis through targeting miR-409-3p/LDHA
title_sort	novel circular rna circatrnl1 accelerates the osteosarcoma aerobic glycolysis through targeting mir-409-3p/ldha
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/b8b6e232cb834dbe8b8189a185c3db96
work_keys_str_mv	AT quanbinzhang novelcircularrnacircatrnl1acceleratestheosteosarcomaaerobicglycolysisthroughtargetingmir4093pldha AT linawang novelcircularrnacircatrnl1acceleratestheosteosarcomaaerobicglycolysisthroughtargetingmir4093pldha AT lilicao novelcircularrnacircatrnl1acceleratestheosteosarcomaaerobicglycolysisthroughtargetingmir4093pldha AT taowei novelcircularrnacircatrnl1acceleratestheosteosarcomaaerobicglycolysisthroughtargetingmir4093pldha
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Novel circular RNA circATRNL1 accelerates the osteosarcoma aerobic glycolysis through targeting miR-409-3p/LDHA

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