DHHC9-mediated GLUT1 S-palmitoylation promotes glioblastoma glycolysis and tumorigenesis

The glucose transporter GLUT1 is upregulated in multiple cancers and may contribute to tumour progression, but the underlying mechanisms are poorly understood. Here, the authors show that DHHC9-mediated GLUT1 palmitoylation at Cys207 is crucial for plasma membrane localisation of GLUT1 and for tumou...

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Autores principales:	Zhenxing Zhang, Xin Li, Fan Yang, Chao Chen, Ping Liu, Yi Ren, Pengkai Sun, Zixiong Wang, Yongping You, Yi-Xin Zeng, Xinjian Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b8b913d2c1a64f169a6b4afab3593903
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spelling	oai:doaj.org-article:b8b913d2c1a64f169a6b4afab35939032021-12-02T18:37:28ZDHHC9-mediated GLUT1 S-palmitoylation promotes glioblastoma glycolysis and tumorigenesis10.1038/s41467-021-26180-42041-1723https://doaj.org/article/b8b913d2c1a64f169a6b4afab35939032021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26180-4https://doaj.org/toc/2041-1723The glucose transporter GLUT1 is upregulated in multiple cancers and may contribute to tumour progression, but the underlying mechanisms are poorly understood. Here, the authors show that DHHC9-mediated GLUT1 palmitoylation at Cys207 is crucial for plasma membrane localisation of GLUT1 and for tumourigenesis in glioblastoma cells.Zhenxing ZhangXin LiFan YangChao ChenPing LiuYi RenPengkai SunZixiong WangYongping YouYi-Xin ZengXinjian LiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhenxing Zhang Xin Li Fan Yang Chao Chen Ping Liu Yi Ren Pengkai Sun Zixiong Wang Yongping You Yi-Xin Zeng Xinjian Li DHHC9-mediated GLUT1 S-palmitoylation promotes glioblastoma glycolysis and tumorigenesis
description	The glucose transporter GLUT1 is upregulated in multiple cancers and may contribute to tumour progression, but the underlying mechanisms are poorly understood. Here, the authors show that DHHC9-mediated GLUT1 palmitoylation at Cys207 is crucial for plasma membrane localisation of GLUT1 and for tumourigenesis in glioblastoma cells.
format	article
author	Zhenxing Zhang Xin Li Fan Yang Chao Chen Ping Liu Yi Ren Pengkai Sun Zixiong Wang Yongping You Yi-Xin Zeng Xinjian Li
author_facet	Zhenxing Zhang Xin Li Fan Yang Chao Chen Ping Liu Yi Ren Pengkai Sun Zixiong Wang Yongping You Yi-Xin Zeng Xinjian Li
author_sort	Zhenxing Zhang
title	DHHC9-mediated GLUT1 S-palmitoylation promotes glioblastoma glycolysis and tumorigenesis
title_short	DHHC9-mediated GLUT1 S-palmitoylation promotes glioblastoma glycolysis and tumorigenesis
title_full	DHHC9-mediated GLUT1 S-palmitoylation promotes glioblastoma glycolysis and tumorigenesis
title_fullStr	DHHC9-mediated GLUT1 S-palmitoylation promotes glioblastoma glycolysis and tumorigenesis
title_full_unstemmed	DHHC9-mediated GLUT1 S-palmitoylation promotes glioblastoma glycolysis and tumorigenesis
title_sort	dhhc9-mediated glut1 s-palmitoylation promotes glioblastoma glycolysis and tumorigenesis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b8b913d2c1a64f169a6b4afab3593903
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DHHC9-mediated GLUT1 S-palmitoylation promotes glioblastoma glycolysis and tumorigenesis

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