INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication

HIV-1 integrase (IN) binds the host factor INI1/SMARCB1, which is required at multiple stages of HIV-1 replication. Here, the authors show that the same IN residues are involved in INI1 and RNA binding and in influencing particle morphogenesis and suggest that the IN-binding INI1 domain is structura...

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Autores principales: Updesh Dixit, Savita Bhutoria, Xuhong Wu, Liming Qiu, Menachem Spira, Sheeba Mathew, Richard Harris, Lucas J. Adams, Sean Cahill, Rajiv Pathak, P. Rajesh Kumar, Minh Nguyen, Seetharama A. Acharya, Michael Brenowitz, Steven C. Almo, Xiaoqin Zou, Alasdair C. Steven, David Cowburn, Mark Girvin, Ganjam V. Kalpana
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Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/b8bafab2f92543e6a097c5d975bbcf2d
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spelling oai:doaj.org-article:b8bafab2f92543e6a097c5d975bbcf2d2021-12-02T15:54:58ZINI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication10.1038/s41467-021-22733-92041-1723https://doaj.org/article/b8bafab2f92543e6a097c5d975bbcf2d2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22733-9https://doaj.org/toc/2041-1723HIV-1 integrase (IN) binds the host factor INI1/SMARCB1, which is required at multiple stages of HIV-1 replication. Here, the authors show that the same IN residues are involved in INI1 and RNA binding and in influencing particle morphogenesis and suggest that the IN-binding INI1 domain is structurally similar to HIV TAR RNA.Updesh DixitSavita BhutoriaXuhong WuLiming QiuMenachem SpiraSheeba MathewRichard HarrisLucas J. AdamsSean CahillRajiv PathakP. Rajesh KumarMinh NguyenSeetharama A. AcharyaMichael BrenowitzSteven C. AlmoXiaoqin ZouAlasdair C. StevenDavid CowburnMark GirvinGanjam V. KalpanaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Updesh Dixit
Savita Bhutoria
Xuhong Wu
Liming Qiu
Menachem Spira
Sheeba Mathew
Richard Harris
Lucas J. Adams
Sean Cahill
Rajiv Pathak
P. Rajesh Kumar
Minh Nguyen
Seetharama A. Acharya
Michael Brenowitz
Steven C. Almo
Xiaoqin Zou
Alasdair C. Steven
David Cowburn
Mark Girvin
Ganjam V. Kalpana
INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication
description HIV-1 integrase (IN) binds the host factor INI1/SMARCB1, which is required at multiple stages of HIV-1 replication. Here, the authors show that the same IN residues are involved in INI1 and RNA binding and in influencing particle morphogenesis and suggest that the IN-binding INI1 domain is structurally similar to HIV TAR RNA.
format article
author Updesh Dixit
Savita Bhutoria
Xuhong Wu
Liming Qiu
Menachem Spira
Sheeba Mathew
Richard Harris
Lucas J. Adams
Sean Cahill
Rajiv Pathak
P. Rajesh Kumar
Minh Nguyen
Seetharama A. Acharya
Michael Brenowitz
Steven C. Almo
Xiaoqin Zou
Alasdair C. Steven
David Cowburn
Mark Girvin
Ganjam V. Kalpana
author_facet Updesh Dixit
Savita Bhutoria
Xuhong Wu
Liming Qiu
Menachem Spira
Sheeba Mathew
Richard Harris
Lucas J. Adams
Sean Cahill
Rajiv Pathak
P. Rajesh Kumar
Minh Nguyen
Seetharama A. Acharya
Michael Brenowitz
Steven C. Almo
Xiaoqin Zou
Alasdair C. Steven
David Cowburn
Mark Girvin
Ganjam V. Kalpana
author_sort Updesh Dixit
title INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication
title_short INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication
title_full INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication
title_fullStr INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication
title_full_unstemmed INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication
title_sort ini1/smarcb1 rpt1 domain mimics tar rna in binding to integrase to facilitate hiv-1 replication
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/b8bafab2f92543e6a097c5d975bbcf2d
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