INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication

HIV-1 integrase (IN) binds the host factor INI1/SMARCB1, which is required at multiple stages of HIV-1 replication. Here, the authors show that the same IN residues are involved in INI1 and RNA binding and in influencing particle morphogenesis and suggest that the IN-binding INI1 domain is structura...

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Autores principales:	Updesh Dixit, Savita Bhutoria, Xuhong Wu, Liming Qiu, Menachem Spira, Sheeba Mathew, Richard Harris, Lucas J. Adams, Sean Cahill, Rajiv Pathak, P. Rajesh Kumar, Minh Nguyen, Seetharama A. Acharya, Michael Brenowitz, Steven C. Almo, Xiaoqin Zou, Alasdair C. Steven, David Cowburn, Mark Girvin, Ganjam V. Kalpana
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b8bafab2f92543e6a097c5d975bbcf2d
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spelling	oai:doaj.org-article:b8bafab2f92543e6a097c5d975bbcf2d2021-12-02T15:54:58ZINI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication10.1038/s41467-021-22733-92041-1723https://doaj.org/article/b8bafab2f92543e6a097c5d975bbcf2d2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22733-9https://doaj.org/toc/2041-1723HIV-1 integrase (IN) binds the host factor INI1/SMARCB1, which is required at multiple stages of HIV-1 replication. Here, the authors show that the same IN residues are involved in INI1 and RNA binding and in influencing particle morphogenesis and suggest that the IN-binding INI1 domain is structurally similar to HIV TAR RNA.Updesh DixitSavita BhutoriaXuhong WuLiming QiuMenachem SpiraSheeba MathewRichard HarrisLucas J. AdamsSean CahillRajiv PathakP. Rajesh KumarMinh NguyenSeetharama A. AcharyaMichael BrenowitzSteven C. AlmoXiaoqin ZouAlasdair C. StevenDavid CowburnMark GirvinGanjam V. KalpanaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Updesh Dixit Savita Bhutoria Xuhong Wu Liming Qiu Menachem Spira Sheeba Mathew Richard Harris Lucas J. Adams Sean Cahill Rajiv Pathak P. Rajesh Kumar Minh Nguyen Seetharama A. Acharya Michael Brenowitz Steven C. Almo Xiaoqin Zou Alasdair C. Steven David Cowburn Mark Girvin Ganjam V. Kalpana INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication
description	HIV-1 integrase (IN) binds the host factor INI1/SMARCB1, which is required at multiple stages of HIV-1 replication. Here, the authors show that the same IN residues are involved in INI1 and RNA binding and in influencing particle morphogenesis and suggest that the IN-binding INI1 domain is structurally similar to HIV TAR RNA.
format	article
author	Updesh Dixit Savita Bhutoria Xuhong Wu Liming Qiu Menachem Spira Sheeba Mathew Richard Harris Lucas J. Adams Sean Cahill Rajiv Pathak P. Rajesh Kumar Minh Nguyen Seetharama A. Acharya Michael Brenowitz Steven C. Almo Xiaoqin Zou Alasdair C. Steven David Cowburn Mark Girvin Ganjam V. Kalpana
author_facet	Updesh Dixit Savita Bhutoria Xuhong Wu Liming Qiu Menachem Spira Sheeba Mathew Richard Harris Lucas J. Adams Sean Cahill Rajiv Pathak P. Rajesh Kumar Minh Nguyen Seetharama A. Acharya Michael Brenowitz Steven C. Almo Xiaoqin Zou Alasdair C. Steven David Cowburn Mark Girvin Ganjam V. Kalpana
author_sort	Updesh Dixit
title	INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication
title_short	INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication
title_full	INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication
title_fullStr	INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication
title_full_unstemmed	INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication
title_sort	ini1/smarcb1 rpt1 domain mimics tar rna in binding to integrase to facilitate hiv-1 replication
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b8bafab2f92543e6a097c5d975bbcf2d
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INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication

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