INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication
HIV-1 integrase (IN) binds the host factor INI1/SMARCB1, which is required at multiple stages of HIV-1 replication. Here, the authors show that the same IN residues are involved in INI1 and RNA binding and in influencing particle morphogenesis and suggest that the IN-binding INI1 domain is structura...
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Nature Portfolio
2021
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oai:doaj.org-article:b8bafab2f92543e6a097c5d975bbcf2d2021-12-02T15:54:58ZINI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication10.1038/s41467-021-22733-92041-1723https://doaj.org/article/b8bafab2f92543e6a097c5d975bbcf2d2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22733-9https://doaj.org/toc/2041-1723HIV-1 integrase (IN) binds the host factor INI1/SMARCB1, which is required at multiple stages of HIV-1 replication. Here, the authors show that the same IN residues are involved in INI1 and RNA binding and in influencing particle morphogenesis and suggest that the IN-binding INI1 domain is structurally similar to HIV TAR RNA.Updesh DixitSavita BhutoriaXuhong WuLiming QiuMenachem SpiraSheeba MathewRichard HarrisLucas J. AdamsSean CahillRajiv PathakP. Rajesh KumarMinh NguyenSeetharama A. AcharyaMichael BrenowitzSteven C. AlmoXiaoqin ZouAlasdair C. StevenDavid CowburnMark GirvinGanjam V. KalpanaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021) |
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Science Q Updesh Dixit Savita Bhutoria Xuhong Wu Liming Qiu Menachem Spira Sheeba Mathew Richard Harris Lucas J. Adams Sean Cahill Rajiv Pathak P. Rajesh Kumar Minh Nguyen Seetharama A. Acharya Michael Brenowitz Steven C. Almo Xiaoqin Zou Alasdair C. Steven David Cowburn Mark Girvin Ganjam V. Kalpana INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication |
description |
HIV-1 integrase (IN) binds the host factor INI1/SMARCB1, which is required at multiple stages of HIV-1 replication. Here, the authors show that the same IN residues are involved in INI1 and RNA binding and in influencing particle morphogenesis and suggest that the IN-binding INI1 domain is structurally similar to HIV TAR RNA. |
format |
article |
author |
Updesh Dixit Savita Bhutoria Xuhong Wu Liming Qiu Menachem Spira Sheeba Mathew Richard Harris Lucas J. Adams Sean Cahill Rajiv Pathak P. Rajesh Kumar Minh Nguyen Seetharama A. Acharya Michael Brenowitz Steven C. Almo Xiaoqin Zou Alasdair C. Steven David Cowburn Mark Girvin Ganjam V. Kalpana |
author_facet |
Updesh Dixit Savita Bhutoria Xuhong Wu Liming Qiu Menachem Spira Sheeba Mathew Richard Harris Lucas J. Adams Sean Cahill Rajiv Pathak P. Rajesh Kumar Minh Nguyen Seetharama A. Acharya Michael Brenowitz Steven C. Almo Xiaoqin Zou Alasdair C. Steven David Cowburn Mark Girvin Ganjam V. Kalpana |
author_sort |
Updesh Dixit |
title |
INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication |
title_short |
INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication |
title_full |
INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication |
title_fullStr |
INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication |
title_full_unstemmed |
INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication |
title_sort |
ini1/smarcb1 rpt1 domain mimics tar rna in binding to integrase to facilitate hiv-1 replication |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/b8bafab2f92543e6a097c5d975bbcf2d |
work_keys_str_mv |
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