Cell competition corrects noisy Wnt morphogen gradients to achieve robust patterning in the zebrafish embryo
Gradients of morphogens such as Wnt provide instructive cues for cell identities during development. Here, the authors report that in the developing zebrafish embryo, cell competition and elimination of unfit cells are required for proper Wnt gradient formation.
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Nature Portfolio
2019
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oai:doaj.org-article:b8bdf608e4c044408a0b01088889fa792021-12-02T17:31:52ZCell competition corrects noisy Wnt morphogen gradients to achieve robust patterning in the zebrafish embryo10.1038/s41467-019-12609-42041-1723https://doaj.org/article/b8bdf608e4c044408a0b01088889fa792019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12609-4https://doaj.org/toc/2041-1723Gradients of morphogens such as Wnt provide instructive cues for cell identities during development. Here, the authors report that in the developing zebrafish embryo, cell competition and elimination of unfit cells are required for proper Wnt gradient formation.Yuki AkiedaShohei OgaminoHironobu FuruieShizuka IshitaniRyutaro AkiyoshiJumpei NogamiTakamasa MasudaNobuyuki ShimizuYasuyuki OhkawaTohru IshitaniNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Yuki Akieda Shohei Ogamino Hironobu Furuie Shizuka Ishitani Ryutaro Akiyoshi Jumpei Nogami Takamasa Masuda Nobuyuki Shimizu Yasuyuki Ohkawa Tohru Ishitani Cell competition corrects noisy Wnt morphogen gradients to achieve robust patterning in the zebrafish embryo |
| description |
Gradients of morphogens such as Wnt provide instructive cues for cell identities during development. Here, the authors report that in the developing zebrafish embryo, cell competition and elimination of unfit cells are required for proper Wnt gradient formation. |
| format |
article |
| author |
Yuki Akieda Shohei Ogamino Hironobu Furuie Shizuka Ishitani Ryutaro Akiyoshi Jumpei Nogami Takamasa Masuda Nobuyuki Shimizu Yasuyuki Ohkawa Tohru Ishitani |
| author_facet |
Yuki Akieda Shohei Ogamino Hironobu Furuie Shizuka Ishitani Ryutaro Akiyoshi Jumpei Nogami Takamasa Masuda Nobuyuki Shimizu Yasuyuki Ohkawa Tohru Ishitani |
| author_sort |
Yuki Akieda |
| title |
Cell competition corrects noisy Wnt morphogen gradients to achieve robust patterning in the zebrafish embryo |
| title_short |
Cell competition corrects noisy Wnt morphogen gradients to achieve robust patterning in the zebrafish embryo |
| title_full |
Cell competition corrects noisy Wnt morphogen gradients to achieve robust patterning in the zebrafish embryo |
| title_fullStr |
Cell competition corrects noisy Wnt morphogen gradients to achieve robust patterning in the zebrafish embryo |
| title_full_unstemmed |
Cell competition corrects noisy Wnt morphogen gradients to achieve robust patterning in the zebrafish embryo |
| title_sort |
cell competition corrects noisy wnt morphogen gradients to achieve robust patterning in the zebrafish embryo |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/b8bdf608e4c044408a0b01088889fa79 |
| work_keys_str_mv |
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1718380452353409024 |