Melatonin and Pathological Cell Interactions: Mitochondrial Glucose Processing in Cancer Cells

The Tibetan Plateau (TP), atmosphere, and Indo-Pacific warm pool (IPWP) together constitute a regional land–atmosphere–ocean water vapor transport system. This study uses remote sensing data, reanalysis data, and observational data to explore the spatiotemporal variations of the summer atmospheric w...

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Autores principales:	Russel J Reiter, Ramaswamy Sharma, Sergio Rosales-Corral, Walter Manucha, Luiz Gustavo de Almeida Gustavo de Almeida Chuffa, Debora Aparecida Pires de Campos Aparecida Pires de Campos Zuccari
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	n/a Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/b8c075225f5941d3bd0da924f60871b4
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spelling	oai:doaj.org-article:b8c075225f5941d3bd0da924f60871b42021-11-25T17:57:14ZMelatonin and Pathological Cell Interactions: Mitochondrial Glucose Processing in Cancer Cells10.3390/ijms2222124941422-00671661-6596https://doaj.org/article/b8c075225f5941d3bd0da924f60871b42021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12494https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The Tibetan Plateau (TP), atmosphere, and Indo-Pacific warm pool (IPWP) together constitute a regional land–atmosphere–ocean water vapor transport system. This study uses remote sensing data, reanalysis data, and observational data to explore the spatiotemporal variations of the summer atmospheric water cycle over the TP and its possible response to the air–sea interaction in the IPWP during the period 1958–2019. The results reveal that the atmospheric water cycle process over the TP presented an interannual and interdecadal strengthening trend. The climatic precipitation recycle ratio (PRR) over the TP was 18%, and the stronger the evapotranspiration, the higher the PRR. On the interdecadal scale, the change in evapotranspiration has a significant negative correlation with the Pacific Decadal Oscillation (PDO) index. The variability of the water vapor transport (WVT) over the TP was controlled by the dynamic and thermal conditions inside the plateau and the external air–sea interaction processes of the IPWP. When the summer monsoon over the TP was strong, there was an anomalous cyclonic WVT, which increased the water vapor budget (<em>WVB</em>) over the TP. The central and eastern tropical Pacific, the maritime continent and the western Indian Ocean together constituted the triple Sea Surface Temperature (SST) anomaly, which enhanced the convective activity over the IPWP and induced a significant easterly wind anomaly in the middle and lower troposphere, and then generated pronounced easterly WVT anomalies from the tropical Pacific to the maritime continent and the Bay of Bengal. Affected by the air–sea changes in the IPWP, the combined effects of the upstream strengthening and the downstream weakening in the water vapor transport process, directly and indirectly, increased the water vapor transport and budget of TP.Russel J ReiterRamaswamy SharmaSergio Rosales-CorralWalter ManuchaLuiz Gustavo de Almeida Gustavo de Almeida ChuffaDebora Aparecida Pires de Campos Aparecida Pires de Campos ZuccariMDPI AGarticlen/aBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12494, p 12494 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	n/a Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	n/a Biology (General) QH301-705.5 Chemistry QD1-999 Russel J Reiter Ramaswamy Sharma Sergio Rosales-Corral Walter Manucha Luiz Gustavo de Almeida Gustavo de Almeida Chuffa Debora Aparecida Pires de Campos Aparecida Pires de Campos Zuccari Melatonin and Pathological Cell Interactions: Mitochondrial Glucose Processing in Cancer Cells
description	The Tibetan Plateau (TP), atmosphere, and Indo-Pacific warm pool (IPWP) together constitute a regional land–atmosphere–ocean water vapor transport system. This study uses remote sensing data, reanalysis data, and observational data to explore the spatiotemporal variations of the summer atmospheric water cycle over the TP and its possible response to the air–sea interaction in the IPWP during the period 1958–2019. The results reveal that the atmospheric water cycle process over the TP presented an interannual and interdecadal strengthening trend. The climatic precipitation recycle ratio (PRR) over the TP was 18%, and the stronger the evapotranspiration, the higher the PRR. On the interdecadal scale, the change in evapotranspiration has a significant negative correlation with the Pacific Decadal Oscillation (PDO) index. The variability of the water vapor transport (WVT) over the TP was controlled by the dynamic and thermal conditions inside the plateau and the external air–sea interaction processes of the IPWP. When the summer monsoon over the TP was strong, there was an anomalous cyclonic WVT, which increased the water vapor budget (<em>WVB</em>) over the TP. The central and eastern tropical Pacific, the maritime continent and the western Indian Ocean together constituted the triple Sea Surface Temperature (SST) anomaly, which enhanced the convective activity over the IPWP and induced a significant easterly wind anomaly in the middle and lower troposphere, and then generated pronounced easterly WVT anomalies from the tropical Pacific to the maritime continent and the Bay of Bengal. Affected by the air–sea changes in the IPWP, the combined effects of the upstream strengthening and the downstream weakening in the water vapor transport process, directly and indirectly, increased the water vapor transport and budget of TP.
format	article
author	Russel J Reiter Ramaswamy Sharma Sergio Rosales-Corral Walter Manucha Luiz Gustavo de Almeida Gustavo de Almeida Chuffa Debora Aparecida Pires de Campos Aparecida Pires de Campos Zuccari
author_facet	Russel J Reiter Ramaswamy Sharma Sergio Rosales-Corral Walter Manucha Luiz Gustavo de Almeida Gustavo de Almeida Chuffa Debora Aparecida Pires de Campos Aparecida Pires de Campos Zuccari
author_sort	Russel J Reiter
title	Melatonin and Pathological Cell Interactions: Mitochondrial Glucose Processing in Cancer Cells
title_short	Melatonin and Pathological Cell Interactions: Mitochondrial Glucose Processing in Cancer Cells
title_full	Melatonin and Pathological Cell Interactions: Mitochondrial Glucose Processing in Cancer Cells
title_fullStr	Melatonin and Pathological Cell Interactions: Mitochondrial Glucose Processing in Cancer Cells
title_full_unstemmed	Melatonin and Pathological Cell Interactions: Mitochondrial Glucose Processing in Cancer Cells
title_sort	melatonin and pathological cell interactions: mitochondrial glucose processing in cancer cells
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b8c075225f5941d3bd0da924f60871b4
work_keys_str_mv	AT russeljreiter melatoninandpathologicalcellinteractionsmitochondrialglucoseprocessingincancercells AT ramaswamysharma melatoninandpathologicalcellinteractionsmitochondrialglucoseprocessingincancercells AT sergiorosalescorral melatoninandpathologicalcellinteractionsmitochondrialglucoseprocessingincancercells AT waltermanucha melatoninandpathologicalcellinteractionsmitochondrialglucoseprocessingincancercells AT luizgustavodealmeidagustavodealmeidachuffa melatoninandpathologicalcellinteractionsmitochondrialglucoseprocessingincancercells AT deboraaparecidapiresdecamposaparecidapiresdecamposzuccari melatoninandpathologicalcellinteractionsmitochondrialglucoseprocessingincancercells
_version_	1718411824419831808

Melatonin and Pathological Cell Interactions: Mitochondrial Glucose Processing in Cancer Cells

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