Muscular and systemic correlates of resistance training-induced muscle hypertrophy.

<h4>Purpose</h4>To determine relationships between post-exercise changes in systemic [testosterone, growth hormone (GH), insulin like grow factor 1 (IGF-1) and interleukin 6 (IL-6)], or intramuscular [skeletal muscle androgen receptor (AR) protein content and p70S6K phosphorylation statu...

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Autores principales:	Cameron J Mitchell, Tyler A Churchward-Venne, Leeann Bellamy, Gianni Parise, Steven K Baker, Stuart M Phillips
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b8c9b346037d412d840a1050a0d3f874
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spelling	oai:doaj.org-article:b8c9b346037d412d840a1050a0d3f8742021-11-18T08:51:42ZMuscular and systemic correlates of resistance training-induced muscle hypertrophy.1932-620310.1371/journal.pone.0078636https://doaj.org/article/b8c9b346037d412d840a1050a0d3f8742013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24130904/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Purpose</h4>To determine relationships between post-exercise changes in systemic [testosterone, growth hormone (GH), insulin like grow factor 1 (IGF-1) and interleukin 6 (IL-6)], or intramuscular [skeletal muscle androgen receptor (AR) protein content and p70S6K phosphorylation status] factors in a moderately-sized cohort of young men exhibiting divergent resistance training-mediated muscle hypertrophy.<h4>Methods</h4>Twenty three adult males completed 4 sessions•wk⁻¹ of resistance training for 16 wk. Muscle biopsies were obtained before and after the training period and acutely 1 and 5 h after the first training session. Serum hormones and cytokines were measured immediately, 15, 30 and 60 minutes following the first and last training sessions of the study.<h4>Results</h4>Mean fiber area increased by 20% (range: -7 to 80%; P<0.001). Protein content of the AR was unchanged with training (fold change = 1.17 ± 0.61; P=0.19); however, there was a significant correlation between the changes in AR content and fiber area (r=0.60, P=0.023). Phosphorylation of p70S6K was elevated 5 hours following exercise, which was correlated with gains in mean fiber area (r=0.54, P=0.007). There was no relationship between the magnitude of the pre- or post-training exercise-induced changes in free testosterone, GH, or IGF-1 concentration and muscle fiber hypertrophy; however, the magnitude of the post exercise IL-6 response was correlated with muscle hypertrophy (r=0.48, P=0.019).<h4>Conclusion</h4>Post-exercise increases in circulating hormones are not related to hypertrophy following training. Exercise-induced changes in IL-6 correlated with hypertrophy, but the mechanism for the role of IL-6 in hypertrophy is not known. Acute increases, in p70S6K phosphorylation and changes in muscle AR protein content correlated with muscle hypertrophy implicating intramuscular rather than systemic processes in mediating hypertrophy.Cameron J MitchellTyler A Churchward-VenneLeeann BellamyGianni PariseSteven K BakerStuart M PhillipsPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 10, p e78636 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cameron J Mitchell Tyler A Churchward-Venne Leeann Bellamy Gianni Parise Steven K Baker Stuart M Phillips Muscular and systemic correlates of resistance training-induced muscle hypertrophy.
description	<h4>Purpose</h4>To determine relationships between post-exercise changes in systemic [testosterone, growth hormone (GH), insulin like grow factor 1 (IGF-1) and interleukin 6 (IL-6)], or intramuscular [skeletal muscle androgen receptor (AR) protein content and p70S6K phosphorylation status] factors in a moderately-sized cohort of young men exhibiting divergent resistance training-mediated muscle hypertrophy.<h4>Methods</h4>Twenty three adult males completed 4 sessions•wk⁻¹ of resistance training for 16 wk. Muscle biopsies were obtained before and after the training period and acutely 1 and 5 h after the first training session. Serum hormones and cytokines were measured immediately, 15, 30 and 60 minutes following the first and last training sessions of the study.<h4>Results</h4>Mean fiber area increased by 20% (range: -7 to 80%; P<0.001). Protein content of the AR was unchanged with training (fold change = 1.17 ± 0.61; P=0.19); however, there was a significant correlation between the changes in AR content and fiber area (r=0.60, P=0.023). Phosphorylation of p70S6K was elevated 5 hours following exercise, which was correlated with gains in mean fiber area (r=0.54, P=0.007). There was no relationship between the magnitude of the pre- or post-training exercise-induced changes in free testosterone, GH, or IGF-1 concentration and muscle fiber hypertrophy; however, the magnitude of the post exercise IL-6 response was correlated with muscle hypertrophy (r=0.48, P=0.019).<h4>Conclusion</h4>Post-exercise increases in circulating hormones are not related to hypertrophy following training. Exercise-induced changes in IL-6 correlated with hypertrophy, but the mechanism for the role of IL-6 in hypertrophy is not known. Acute increases, in p70S6K phosphorylation and changes in muscle AR protein content correlated with muscle hypertrophy implicating intramuscular rather than systemic processes in mediating hypertrophy.
format	article
author	Cameron J Mitchell Tyler A Churchward-Venne Leeann Bellamy Gianni Parise Steven K Baker Stuart M Phillips
author_facet	Cameron J Mitchell Tyler A Churchward-Venne Leeann Bellamy Gianni Parise Steven K Baker Stuart M Phillips
author_sort	Cameron J Mitchell
title	Muscular and systemic correlates of resistance training-induced muscle hypertrophy.
title_short	Muscular and systemic correlates of resistance training-induced muscle hypertrophy.
title_full	Muscular and systemic correlates of resistance training-induced muscle hypertrophy.
title_fullStr	Muscular and systemic correlates of resistance training-induced muscle hypertrophy.
title_full_unstemmed	Muscular and systemic correlates of resistance training-induced muscle hypertrophy.
title_sort	muscular and systemic correlates of resistance training-induced muscle hypertrophy.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/b8c9b346037d412d840a1050a0d3f874
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Muscular and systemic correlates of resistance training-induced muscle hypertrophy.

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