Shared heritability and functional enrichment across six solid cancers

Similarities in cancers can be studied to interrogate their etiology. Here, the authors use genome-wide association study summary statistics from six cancer types based on 296,215 cases and 301,319 controls of European ancestry, showing that solid tumours arising from different tissues share a degre...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xia Jiang, Hilary K. Finucane, Fredrick R. Schumacher, Stephanie L. Schmit, Jonathan P. Tyrer, Younghun Han, Kyriaki Michailidou, Corina Lesseur, Karoline B. Kuchenbaecker, Joe Dennis, David V. Conti, Graham Casey, Mia M. Gaudet, Jeroen R. Huyghe, Demetrius Albanes, Melinda C. Aldrich, Angeline S. Andrew, Irene L. Andrulis, Hoda Anton-Culver, Antonis C. Antoniou, Natalia N. Antonenkova, Susanne M. Arnold, Kristan J. Aronson, Banu K. Arun, Elisa V. Bandera, Rosa B. Barkardottir, Daniel R. Barnes, Jyotsna Batra, Matthias W. Beckmann, Javier Benitez, Sara Benlloch, Andrew Berchuck, Sonja I. Berndt, Heike Bickeböller, Stephanie A. Bien, Carl Blomqvist, Stefania Boccia, Natalia V. Bogdanova, Stig E. Bojesen, Manjeet K. Bolla, Hiltrud Brauch, Hermann Brenner, James D. Brenton, Mark N. Brook, Joan Brunet, Hans Brunnström, Daniel D. Buchanan, Barbara Burwinkel, Ralf Butzow, Gabriella Cadoni, Trinidad Caldés, Maria A. Caligo, Ian Campbell, Peter T. Campbell, Géraldine Cancel-Tassin, Lisa Cannon-Albright, Daniele Campa, Neil Caporaso, André L. Carvalho, Andrew T. Chan, Jenny Chang-Claude, Stephen J. Chanock, Chu Chen, David C. Christiani, Kathleen B. M. Claes, Frank Claessens, Judith Clements, J. Margriet Collée, Marcia Cruz Correa, Fergus J. Couch, Angela Cox, Julie M. Cunningham, Cezary Cybulski, Kamila Czene, Mary B. Daly, Anna deFazio, Peter Devilee, Orland Diez, Manuela Gago-Dominguez, Jenny L. Donovan, Thilo Dörk, Eric J. Duell, Alison M. Dunning, Miriam Dwek, Diana M. Eccles, Christopher K. Edlund, Digna R Velez Edwards, Carolina Ellberg, D. Gareth Evans, Peter A. Fasching, Robert L. Ferris, Triantafillos Liloglou, Jane C. Figueiredo, Olivia Fletcher, Renée T. Fortner, Florentia Fostira, Silvia Franceschi, Eitan Friedman, Steven J. Gallinger, Patricia A. Ganz, Judy Garber, José A. García-Sáenz, Simon A. Gayther, Graham G. Giles, Andrew K. Godwin, Mark S. Goldberg, David E. Goldgar, Ellen L. Goode, Marc T. Goodman, Gary Goodman, Kjell Grankvist, Mark H. Greene, Henrik Gronberg, Jacek Gronwald, Pascal Guénel, Niclas Håkansson, Per Hall, Ute Hamann, Freddie C. Hamdy, Robert J. Hamilton, Jochen Hampe, Aage Haugen, Florian Heitz, Rolando Herrero, Peter Hillemanns, Michael Hoffmeister, Estrid Høgdall, Yun-Chul Hong, John L. Hopper, Richard Houlston, Peter J. Hulick, David J. Hunter, David G. Huntsman, Gregory Idos, Evgeny N. Imyanitov, Sue Ann Ingles, Claudine Isaacs, Anna Jakubowska, Paul James, Mark A. Jenkins, Mattias Johansson, Mikael Johansson, Esther M. John, Amit D. Joshi, Radka Kaneva, Beth Y. Karlan, Linda E. Kelemen, Tabea Kühl, Kay-Tee Khaw, Elza Khusnutdinova, Adam S. Kibel, Lambertus A. Kiemeney, Jeri Kim, Susanne K. Kjaer, Julia A. Knight, Manolis Kogevinas, Zsofia Kote-Jarai, Stella Koutros, Vessela N. Kristensen, Jolanta Kupryjanczyk, Martin Lacko, Stephan Lam, Diether Lambrechts, Maria Teresa Landi, Philip Lazarus, Nhu D. Le, Eunjung Lee, Flavio Lejbkowicz, Heinz-Josef Lenz, Goska Leslie, Davor Lessel, Jenny Lester, Douglas A. Levine, Li Li, Christopher I. Li, Annika Lindblom, Noralane M. Lindor, Geoffrey Liu, Fotios Loupakis, Jan Lubiński, Lovise Maehle, Christiane Maier, Arto Mannermaa, Loic Le Marchand, Sara Margolin, Taymaa May, Lesley McGuffog, Alfons Meindl, Pooja Middha, Austin Miller, Roger L. Milne, Robert J. MacInnis, Francesmary Modugno, Marco Montagna, Victor Moreno, Kirsten B. Moysich, Lorelei Mucci, Kenneth Muir, Anna Marie Mulligan, Katherine L. Nathanson, David E. Neal, Andrew R. Ness, Susan L. Neuhausen, Heli Nevanlinna, Polly A. Newcomb, Lisa F. Newcomb, Finn Cilius Nielsen, Liene Nikitina-Zake, Børge G. Nordestgaard, Robert L. Nussbaum, Kenneth Offit, Edith Olah, Ali Amin Al Olama, Olufunmilayo I. Olopade, Andrew F. Olshan, Håkan Olsson, Ana Osorio, Hardev Pandha, Jong Y. Park, Nora Pashayan, Michael T. Parsons, Tanja Pejovic, Kathryn L. Penney, Wilbert H M. Peters, Catherine M. Phelan, Amanda I. Phipps, Dijana Plaseska-Karanfilska, Miranda Pring, Darya Prokofyeva, Paolo Radice, Kari Stefansson, Susan J. Ramus, Leon Raskin, Gad Rennert, Hedy S. Rennert, Elizabeth J. van Rensburg, Marjorie J. Riggan, Harvey A. Risch, Angela Risch, Monique J. Roobol, Barry S. Rosenstein, Mary Anne Rossing, Kim De Ruyck, Emmanouil Saloustros, Dale P. Sandler, Elinor J. Sawyer, Matthew B. Schabath, Johanna Schleutker, Marjanka K. Schmidt, V. Wendy Setiawan, Hongbing Shen, Erin M. Siegel, Weiva Sieh, Christian F. Singer, Martha L. Slattery, Karina Dalsgaard Sorensen, Melissa C. Southey, Amanda B. Spurdle, Janet L. Stanford, Victoria L. Stevens, Sebastian Stintzing, Jennifer Stone, Karin Sundfeldt, Rebecca Sutphen, Anthony J. Swerdlow, Eloiza H. Tajara, Catherine M. Tangen, Adonina Tardon, Jack A. Taylor, M. Dawn Teare, Manuel R. Teixeira, Mary Beth Terry, Kathryn L. Terry, Stephen N. Thibodeau, Mads Thomassen, Line Bjørge, Marc Tischkowitz, Amanda E. Toland, Diana Torres, Paul A. Townsend, Ruth C. Travis, Nadine Tung, Shelley S. Tworoger, Cornelia M. Ulrich, Nawaid Usmani, Celine M. Vachon, Els Van Nieuwenhuysen, Ana Vega, Miguel Elías Aguado-Barrera, Qin Wang, Penelope M. Webb, Clarice R. Weinberg, Stephanie Weinstein, Mark C. Weissler, Jeffrey N. Weitzel, Catharine M. L. West, Emily White, Alice S. Whittemore, H-Erich Wichmann, Fredrik Wiklund, Robert Winqvist, Alicja Wolk, Penella Woll, Michael Woods, Anna H. Wu, Xifeng Wu, Drakoulis Yannoukakos, Wei Zheng, Shanbeh Zienolddiny, Argyrios Ziogas, Kristin K. Zorn, Jacqueline M. Lane, Richa Saxena, Duncan Thomas, Rayjean J. Hung, Brenda Diergaarde, James McKay, Ulrike Peters, Li Hsu, Montserrat García-Closas, Rosalind A. Eeles, Georgia Chenevix-Trench, Paul J. Brennan, Christopher A. Haiman, Jacques Simard, Douglas F. Easton, Stephen B. Gruber, Paul D. P. Pharoah, Alkes L. Price, Bogdan Pasaniuc, Christopher I. Amos, Peter Kraft, Sara Lindström
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b8cd2398d6804293b10da647205e9798
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b8cd2398d6804293b10da647205e9798
record_format	dspace
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xia Jiang Hilary K. Finucane Fredrick R. Schumacher Stephanie L. Schmit Jonathan P. Tyrer Younghun Han Kyriaki Michailidou Corina Lesseur Karoline B. Kuchenbaecker Joe Dennis David V. Conti Graham Casey Mia M. Gaudet Jeroen R. Huyghe Demetrius Albanes Melinda C. Aldrich Angeline S. Andrew Irene L. Andrulis Hoda Anton-Culver Antonis C. Antoniou Natalia N. Antonenkova Susanne M. Arnold Kristan J. Aronson Banu K. Arun Elisa V. Bandera Rosa B. Barkardottir Daniel R. Barnes Jyotsna Batra Matthias W. Beckmann Javier Benitez Sara Benlloch Andrew Berchuck Sonja I. Berndt Heike Bickeböller Stephanie A. Bien Carl Blomqvist Stefania Boccia Natalia V. Bogdanova Stig E. Bojesen Manjeet K. Bolla Hiltrud Brauch Hermann Brenner James D. Brenton Mark N. Brook Joan Brunet Hans Brunnström Daniel D. Buchanan Barbara Burwinkel Ralf Butzow Gabriella Cadoni Trinidad Caldés Maria A. Caligo Ian Campbell Peter T. Campbell Géraldine Cancel-Tassin Lisa Cannon-Albright Daniele Campa Neil Caporaso André L. Carvalho Andrew T. Chan Jenny Chang-Claude Stephen J. Chanock Chu Chen David C. Christiani Kathleen B. M. Claes Frank Claessens Judith Clements J. Margriet Collée Marcia Cruz Correa Fergus J. Couch Angela Cox Julie M. Cunningham Cezary Cybulski Kamila Czene Mary B. Daly Anna deFazio Peter Devilee Orland Diez Manuela Gago-Dominguez Jenny L. Donovan Thilo Dörk Eric J. Duell Alison M. Dunning Miriam Dwek Diana M. Eccles Christopher K. Edlund Digna R Velez Edwards Carolina Ellberg D. Gareth Evans Peter A. Fasching Robert L. Ferris Triantafillos Liloglou Jane C. Figueiredo Olivia Fletcher Renée T. Fortner Florentia Fostira Silvia Franceschi Eitan Friedman Steven J. Gallinger Patricia A. Ganz Judy Garber José A. García-Sáenz Simon A. Gayther Graham G. Giles Andrew K. Godwin Mark S. Goldberg David E. Goldgar Ellen L. Goode Marc T. Goodman Gary Goodman Kjell Grankvist Mark H. Greene Henrik Gronberg Jacek Gronwald Pascal Guénel Niclas Håkansson Per Hall Ute Hamann Freddie C. Hamdy Robert J. Hamilton Jochen Hampe Aage Haugen Florian Heitz Rolando Herrero Peter Hillemanns Michael Hoffmeister Estrid Høgdall Yun-Chul Hong John L. Hopper Richard Houlston Peter J. Hulick David J. Hunter David G. Huntsman Gregory Idos Evgeny N. Imyanitov Sue Ann Ingles Claudine Isaacs Anna Jakubowska Paul James Mark A. Jenkins Mattias Johansson Mikael Johansson Esther M. John Amit D. Joshi Radka Kaneva Beth Y. Karlan Linda E. Kelemen Tabea Kühl Kay-Tee Khaw Elza Khusnutdinova Adam S. Kibel Lambertus A. Kiemeney Jeri Kim Susanne K. Kjaer Julia A. Knight Manolis Kogevinas Zsofia Kote-Jarai Stella Koutros Vessela N. Kristensen Jolanta Kupryjanczyk Martin Lacko Stephan Lam Diether Lambrechts Maria Teresa Landi Philip Lazarus Nhu D. Le Eunjung Lee Flavio Lejbkowicz Heinz-Josef Lenz Goska Leslie Davor Lessel Jenny Lester Douglas A. Levine Li Li Christopher I. Li Annika Lindblom Noralane M. Lindor Geoffrey Liu Fotios Loupakis Jan Lubiński Lovise Maehle Christiane Maier Arto Mannermaa Loic Le Marchand Sara Margolin Taymaa May Lesley McGuffog Alfons Meindl Pooja Middha Austin Miller Roger L. Milne Robert J. MacInnis Francesmary Modugno Marco Montagna Victor Moreno Kirsten B. Moysich Lorelei Mucci Kenneth Muir Anna Marie Mulligan Katherine L. Nathanson David E. Neal Andrew R. Ness Susan L. Neuhausen Heli Nevanlinna Polly A. Newcomb Lisa F. Newcomb Finn Cilius Nielsen Liene Nikitina-Zake Børge G. Nordestgaard Robert L. Nussbaum Kenneth Offit Edith Olah Ali Amin Al Olama Olufunmilayo I. Olopade Andrew F. Olshan Håkan Olsson Ana Osorio Hardev Pandha Jong Y. Park Nora Pashayan Michael T. Parsons Tanja Pejovic Kathryn L. Penney Wilbert H M. Peters Catherine M. Phelan Amanda I. Phipps Dijana Plaseska-Karanfilska Miranda Pring Darya Prokofyeva Paolo Radice Kari Stefansson Susan J. Ramus Leon Raskin Gad Rennert Hedy S. Rennert Elizabeth J. van Rensburg Marjorie J. Riggan Harvey A. Risch Angela Risch Monique J. Roobol Barry S. Rosenstein Mary Anne Rossing Kim De Ruyck Emmanouil Saloustros Dale P. Sandler Elinor J. Sawyer Matthew B. Schabath Johanna Schleutker Marjanka K. Schmidt V. Wendy Setiawan Hongbing Shen Erin M. Siegel Weiva Sieh Christian F. Singer Martha L. Slattery Karina Dalsgaard Sorensen Melissa C. Southey Amanda B. Spurdle Janet L. Stanford Victoria L. Stevens Sebastian Stintzing Jennifer Stone Karin Sundfeldt Rebecca Sutphen Anthony J. Swerdlow Eloiza H. Tajara Catherine M. Tangen Adonina Tardon Jack A. Taylor M. Dawn Teare Manuel R. Teixeira Mary Beth Terry Kathryn L. Terry Stephen N. Thibodeau Mads Thomassen Line Bjørge Marc Tischkowitz Amanda E. Toland Diana Torres Paul A. Townsend Ruth C. Travis Nadine Tung Shelley S. Tworoger Cornelia M. Ulrich Nawaid Usmani Celine M. Vachon Els Van Nieuwenhuysen Ana Vega Miguel Elías Aguado-Barrera Qin Wang Penelope M. Webb Clarice R. Weinberg Stephanie Weinstein Mark C. Weissler Jeffrey N. Weitzel Catharine M. L. West Emily White Alice S. Whittemore H-Erich Wichmann Fredrik Wiklund Robert Winqvist Alicja Wolk Penella Woll Michael Woods Anna H. Wu Xifeng Wu Drakoulis Yannoukakos Wei Zheng Shanbeh Zienolddiny Argyrios Ziogas Kristin K. Zorn Jacqueline M. Lane Richa Saxena Duncan Thomas Rayjean J. Hung Brenda Diergaarde James McKay Ulrike Peters Li Hsu Montserrat García-Closas Rosalind A. Eeles Georgia Chenevix-Trench Paul J. Brennan Christopher A. Haiman Jacques Simard Douglas F. Easton Stephen B. Gruber Paul D. P. Pharoah Alkes L. Price Bogdan Pasaniuc Christopher I. Amos Peter Kraft Sara Lindström Shared heritability and functional enrichment across six solid cancers
description	Similarities in cancers can be studied to interrogate their etiology. Here, the authors use genome-wide association study summary statistics from six cancer types based on 296,215 cases and 301,319 controls of European ancestry, showing that solid tumours arising from different tissues share a degree of common germline genetic basis.
format	article
author	Xia Jiang Hilary K. Finucane Fredrick R. Schumacher Stephanie L. Schmit Jonathan P. Tyrer Younghun Han Kyriaki Michailidou Corina Lesseur Karoline B. Kuchenbaecker Joe Dennis David V. Conti Graham Casey Mia M. Gaudet Jeroen R. Huyghe Demetrius Albanes Melinda C. Aldrich Angeline S. Andrew Irene L. Andrulis Hoda Anton-Culver Antonis C. Antoniou Natalia N. Antonenkova Susanne M. Arnold Kristan J. Aronson Banu K. Arun Elisa V. Bandera Rosa B. Barkardottir Daniel R. Barnes Jyotsna Batra Matthias W. Beckmann Javier Benitez Sara Benlloch Andrew Berchuck Sonja I. Berndt Heike Bickeböller Stephanie A. Bien Carl Blomqvist Stefania Boccia Natalia V. Bogdanova Stig E. Bojesen Manjeet K. Bolla Hiltrud Brauch Hermann Brenner James D. Brenton Mark N. Brook Joan Brunet Hans Brunnström Daniel D. Buchanan Barbara Burwinkel Ralf Butzow Gabriella Cadoni Trinidad Caldés Maria A. Caligo Ian Campbell Peter T. Campbell Géraldine Cancel-Tassin Lisa Cannon-Albright Daniele Campa Neil Caporaso André L. Carvalho Andrew T. Chan Jenny Chang-Claude Stephen J. Chanock Chu Chen David C. Christiani Kathleen B. M. Claes Frank Claessens Judith Clements J. Margriet Collée Marcia Cruz Correa Fergus J. Couch Angela Cox Julie M. Cunningham Cezary Cybulski Kamila Czene Mary B. Daly Anna deFazio Peter Devilee Orland Diez Manuela Gago-Dominguez Jenny L. Donovan Thilo Dörk Eric J. Duell Alison M. Dunning Miriam Dwek Diana M. Eccles Christopher K. Edlund Digna R Velez Edwards Carolina Ellberg D. Gareth Evans Peter A. Fasching Robert L. Ferris Triantafillos Liloglou Jane C. Figueiredo Olivia Fletcher Renée T. Fortner Florentia Fostira Silvia Franceschi Eitan Friedman Steven J. Gallinger Patricia A. Ganz Judy Garber José A. García-Sáenz Simon A. Gayther Graham G. Giles Andrew K. Godwin Mark S. Goldberg David E. Goldgar Ellen L. Goode Marc T. Goodman Gary Goodman Kjell Grankvist Mark H. Greene Henrik Gronberg Jacek Gronwald Pascal Guénel Niclas Håkansson Per Hall Ute Hamann Freddie C. Hamdy Robert J. Hamilton Jochen Hampe Aage Haugen Florian Heitz Rolando Herrero Peter Hillemanns Michael Hoffmeister Estrid Høgdall Yun-Chul Hong John L. Hopper Richard Houlston Peter J. Hulick David J. Hunter David G. Huntsman Gregory Idos Evgeny N. Imyanitov Sue Ann Ingles Claudine Isaacs Anna Jakubowska Paul James Mark A. Jenkins Mattias Johansson Mikael Johansson Esther M. John Amit D. Joshi Radka Kaneva Beth Y. Karlan Linda E. Kelemen Tabea Kühl Kay-Tee Khaw Elza Khusnutdinova Adam S. Kibel Lambertus A. Kiemeney Jeri Kim Susanne K. Kjaer Julia A. Knight Manolis Kogevinas Zsofia Kote-Jarai Stella Koutros Vessela N. Kristensen Jolanta Kupryjanczyk Martin Lacko Stephan Lam Diether Lambrechts Maria Teresa Landi Philip Lazarus Nhu D. Le Eunjung Lee Flavio Lejbkowicz Heinz-Josef Lenz Goska Leslie Davor Lessel Jenny Lester Douglas A. Levine Li Li Christopher I. Li Annika Lindblom Noralane M. Lindor Geoffrey Liu Fotios Loupakis Jan Lubiński Lovise Maehle Christiane Maier Arto Mannermaa Loic Le Marchand Sara Margolin Taymaa May Lesley McGuffog Alfons Meindl Pooja Middha Austin Miller Roger L. Milne Robert J. MacInnis Francesmary Modugno Marco Montagna Victor Moreno Kirsten B. Moysich Lorelei Mucci Kenneth Muir Anna Marie Mulligan Katherine L. Nathanson David E. Neal Andrew R. Ness Susan L. Neuhausen Heli Nevanlinna Polly A. Newcomb Lisa F. Newcomb Finn Cilius Nielsen Liene Nikitina-Zake Børge G. Nordestgaard Robert L. Nussbaum Kenneth Offit Edith Olah Ali Amin Al Olama Olufunmilayo I. Olopade Andrew F. Olshan Håkan Olsson Ana Osorio Hardev Pandha Jong Y. Park Nora Pashayan Michael T. Parsons Tanja Pejovic Kathryn L. Penney Wilbert H M. Peters Catherine M. Phelan Amanda I. Phipps Dijana Plaseska-Karanfilska Miranda Pring Darya Prokofyeva Paolo Radice Kari Stefansson Susan J. Ramus Leon Raskin Gad Rennert Hedy S. Rennert Elizabeth J. van Rensburg Marjorie J. Riggan Harvey A. Risch Angela Risch Monique J. Roobol Barry S. Rosenstein Mary Anne Rossing Kim De Ruyck Emmanouil Saloustros Dale P. Sandler Elinor J. Sawyer Matthew B. Schabath Johanna Schleutker Marjanka K. Schmidt V. Wendy Setiawan Hongbing Shen Erin M. Siegel Weiva Sieh Christian F. Singer Martha L. Slattery Karina Dalsgaard Sorensen Melissa C. Southey Amanda B. Spurdle Janet L. Stanford Victoria L. Stevens Sebastian Stintzing Jennifer Stone Karin Sundfeldt Rebecca Sutphen Anthony J. Swerdlow Eloiza H. Tajara Catherine M. Tangen Adonina Tardon Jack A. Taylor M. Dawn Teare Manuel R. Teixeira Mary Beth Terry Kathryn L. Terry Stephen N. Thibodeau Mads Thomassen Line Bjørge Marc Tischkowitz Amanda E. Toland Diana Torres Paul A. Townsend Ruth C. Travis Nadine Tung Shelley S. Tworoger Cornelia M. Ulrich Nawaid Usmani Celine M. Vachon Els Van Nieuwenhuysen Ana Vega Miguel Elías Aguado-Barrera Qin Wang Penelope M. Webb Clarice R. Weinberg Stephanie Weinstein Mark C. Weissler Jeffrey N. Weitzel Catharine M. L. West Emily White Alice S. Whittemore H-Erich Wichmann Fredrik Wiklund Robert Winqvist Alicja Wolk Penella Woll Michael Woods Anna H. Wu Xifeng Wu Drakoulis Yannoukakos Wei Zheng Shanbeh Zienolddiny Argyrios Ziogas Kristin K. Zorn Jacqueline M. Lane Richa Saxena Duncan Thomas Rayjean J. Hung Brenda Diergaarde James McKay Ulrike Peters Li Hsu Montserrat García-Closas Rosalind A. Eeles Georgia Chenevix-Trench Paul J. Brennan Christopher A. Haiman Jacques Simard Douglas F. Easton Stephen B. Gruber Paul D. P. Pharoah Alkes L. Price Bogdan Pasaniuc Christopher I. Amos Peter Kraft Sara Lindström
author_facet	Xia Jiang Hilary K. Finucane Fredrick R. Schumacher Stephanie L. Schmit Jonathan P. Tyrer Younghun Han Kyriaki Michailidou Corina Lesseur Karoline B. Kuchenbaecker Joe Dennis David V. Conti Graham Casey Mia M. Gaudet Jeroen R. Huyghe Demetrius Albanes Melinda C. Aldrich Angeline S. Andrew Irene L. Andrulis Hoda Anton-Culver Antonis C. Antoniou Natalia N. Antonenkova Susanne M. Arnold Kristan J. Aronson Banu K. Arun Elisa V. Bandera Rosa B. Barkardottir Daniel R. Barnes Jyotsna Batra Matthias W. Beckmann Javier Benitez Sara Benlloch Andrew Berchuck Sonja I. Berndt Heike Bickeböller Stephanie A. Bien Carl Blomqvist Stefania Boccia Natalia V. Bogdanova Stig E. Bojesen Manjeet K. Bolla Hiltrud Brauch Hermann Brenner James D. Brenton Mark N. Brook Joan Brunet Hans Brunnström Daniel D. Buchanan Barbara Burwinkel Ralf Butzow Gabriella Cadoni Trinidad Caldés Maria A. Caligo Ian Campbell Peter T. Campbell Géraldine Cancel-Tassin Lisa Cannon-Albright Daniele Campa Neil Caporaso André L. Carvalho Andrew T. Chan Jenny Chang-Claude Stephen J. Chanock Chu Chen David C. Christiani Kathleen B. M. Claes Frank Claessens Judith Clements J. Margriet Collée Marcia Cruz Correa Fergus J. Couch Angela Cox Julie M. Cunningham Cezary Cybulski Kamila Czene Mary B. Daly Anna deFazio Peter Devilee Orland Diez Manuela Gago-Dominguez Jenny L. Donovan Thilo Dörk Eric J. Duell Alison M. Dunning Miriam Dwek Diana M. Eccles Christopher K. Edlund Digna R Velez Edwards Carolina Ellberg D. Gareth Evans Peter A. Fasching Robert L. Ferris Triantafillos Liloglou Jane C. Figueiredo Olivia Fletcher Renée T. Fortner Florentia Fostira Silvia Franceschi Eitan Friedman Steven J. Gallinger Patricia A. Ganz Judy Garber José A. García-Sáenz Simon A. Gayther Graham G. Giles Andrew K. Godwin Mark S. Goldberg David E. Goldgar Ellen L. Goode Marc T. Goodman Gary Goodman Kjell Grankvist Mark H. Greene Henrik Gronberg Jacek Gronwald Pascal Guénel Niclas Håkansson Per Hall Ute Hamann Freddie C. Hamdy Robert J. Hamilton Jochen Hampe Aage Haugen Florian Heitz Rolando Herrero Peter Hillemanns Michael Hoffmeister Estrid Høgdall Yun-Chul Hong John L. Hopper Richard Houlston Peter J. Hulick David J. Hunter David G. Huntsman Gregory Idos Evgeny N. Imyanitov Sue Ann Ingles Claudine Isaacs Anna Jakubowska Paul James Mark A. Jenkins Mattias Johansson Mikael Johansson Esther M. John Amit D. Joshi Radka Kaneva Beth Y. Karlan Linda E. Kelemen Tabea Kühl Kay-Tee Khaw Elza Khusnutdinova Adam S. Kibel Lambertus A. Kiemeney Jeri Kim Susanne K. Kjaer Julia A. Knight Manolis Kogevinas Zsofia Kote-Jarai Stella Koutros Vessela N. Kristensen Jolanta Kupryjanczyk Martin Lacko Stephan Lam Diether Lambrechts Maria Teresa Landi Philip Lazarus Nhu D. Le Eunjung Lee Flavio Lejbkowicz Heinz-Josef Lenz Goska Leslie Davor Lessel Jenny Lester Douglas A. Levine Li Li Christopher I. Li Annika Lindblom Noralane M. Lindor Geoffrey Liu Fotios Loupakis Jan Lubiński Lovise Maehle Christiane Maier Arto Mannermaa Loic Le Marchand Sara Margolin Taymaa May Lesley McGuffog Alfons Meindl Pooja Middha Austin Miller Roger L. Milne Robert J. MacInnis Francesmary Modugno Marco Montagna Victor Moreno Kirsten B. Moysich Lorelei Mucci Kenneth Muir Anna Marie Mulligan Katherine L. Nathanson David E. Neal Andrew R. Ness Susan L. Neuhausen Heli Nevanlinna Polly A. Newcomb Lisa F. Newcomb Finn Cilius Nielsen Liene Nikitina-Zake Børge G. Nordestgaard Robert L. Nussbaum Kenneth Offit Edith Olah Ali Amin Al Olama Olufunmilayo I. Olopade Andrew F. Olshan Håkan Olsson Ana Osorio Hardev Pandha Jong Y. Park Nora Pashayan Michael T. Parsons Tanja Pejovic Kathryn L. Penney Wilbert H M. Peters Catherine M. Phelan Amanda I. Phipps Dijana Plaseska-Karanfilska Miranda Pring Darya Prokofyeva Paolo Radice Kari Stefansson Susan J. Ramus Leon Raskin Gad Rennert Hedy S. Rennert Elizabeth J. van Rensburg Marjorie J. Riggan Harvey A. Risch Angela Risch Monique J. Roobol Barry S. Rosenstein Mary Anne Rossing Kim De Ruyck Emmanouil Saloustros Dale P. Sandler Elinor J. Sawyer Matthew B. Schabath Johanna Schleutker Marjanka K. Schmidt V. Wendy Setiawan Hongbing Shen Erin M. Siegel Weiva Sieh Christian F. Singer Martha L. Slattery Karina Dalsgaard Sorensen Melissa C. Southey Amanda B. Spurdle Janet L. Stanford Victoria L. Stevens Sebastian Stintzing Jennifer Stone Karin Sundfeldt Rebecca Sutphen Anthony J. Swerdlow Eloiza H. Tajara Catherine M. Tangen Adonina Tardon Jack A. Taylor M. Dawn Teare Manuel R. Teixeira Mary Beth Terry Kathryn L. Terry Stephen N. Thibodeau Mads Thomassen Line Bjørge Marc Tischkowitz Amanda E. Toland Diana Torres Paul A. Townsend Ruth C. Travis Nadine Tung Shelley S. Tworoger Cornelia M. Ulrich Nawaid Usmani Celine M. Vachon Els Van Nieuwenhuysen Ana Vega Miguel Elías Aguado-Barrera Qin Wang Penelope M. Webb Clarice R. Weinberg Stephanie Weinstein Mark C. Weissler Jeffrey N. Weitzel Catharine M. L. West Emily White Alice S. Whittemore H-Erich Wichmann Fredrik Wiklund Robert Winqvist Alicja Wolk Penella Woll Michael Woods Anna H. Wu Xifeng Wu Drakoulis Yannoukakos Wei Zheng Shanbeh Zienolddiny Argyrios Ziogas Kristin K. Zorn Jacqueline M. Lane Richa Saxena Duncan Thomas Rayjean J. Hung Brenda Diergaarde James McKay Ulrike Peters Li Hsu Montserrat García-Closas Rosalind A. Eeles Georgia Chenevix-Trench Paul J. Brennan Christopher A. Haiman Jacques Simard Douglas F. Easton Stephen B. Gruber Paul D. P. Pharoah Alkes L. Price Bogdan Pasaniuc Christopher I. Amos Peter Kraft Sara Lindström
author_sort	Xia Jiang
title	Shared heritability and functional enrichment across six solid cancers
title_short	Shared heritability and functional enrichment across six solid cancers
title_full	Shared heritability and functional enrichment across six solid cancers
title_fullStr	Shared heritability and functional enrichment across six solid cancers
title_full_unstemmed	Shared heritability and functional enrichment across six solid cancers
title_sort	shared heritability and functional enrichment across six solid cancers
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b8cd2398d6804293b10da647205e9798
work_keys_str_mv	AT xiajiang sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT hilarykfinucane sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT fredrickrschumacher sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT stephanielschmit sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT jonathanptyrer sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT younghunhan sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT kyriakimichailidou sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT corinalesseur sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT karolinebkuchenbaecker sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT joedennis sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT davidvconti sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT grahamcasey sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT miamgaudet sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT jeroenrhuyghe sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT demetriusalbanes sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT melindacaldrich sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT angelinesandrew sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT irenelandrulis sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT hodaantonculver sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT antoniscantoniou sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT natalianantonenkova sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT susannemarnold sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT kristanjaronson sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT banukarun sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT elisavbandera sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT rosabbarkardottir sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT danielrbarnes sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT jyotsnabatra sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT matthiaswbeckmann sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT javierbenitez sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT sarabenlloch sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT andrewberchuck sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT sonjaiberndt sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT heikebickeboller sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT stephanieabien sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT carlblomqvist sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT stefaniaboccia sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT nataliavbogdanova sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT stigebojesen sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT manjeetkbolla sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT hiltrudbrauch sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT hermannbrenner sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT jamesdbrenton sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT marknbrook sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT joanbrunet sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT hansbrunnstrom sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT danieldbuchanan sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT barbaraburwinkel sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT ralfbutzow sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT gabriellacadoni sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT trinidadcaldes sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT mariaacaligo sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT iancampbell sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT petertcampbell sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT geraldinecanceltassin sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT lisacannonalbright sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT danielecampa sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT neilcaporaso sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT andrelcarvalho sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT andrewtchan sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT jennychangclaude sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT stephenjchanock sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT chuchen sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT davidcchristiani sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT kathleenbmclaes sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT frankclaessens sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT judithclements sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT jmargrietcollee sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT marciacruzcorrea sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT fergusjcouch sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT angelacox sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT juliemcunningham sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT cezarycybulski sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT kamilaczene sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT marybdaly sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT annadefazio sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT peterdevilee sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT orlanddiez sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT manuelagagodominguez sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT jennyldonovan sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT thilodork sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT ericjduell sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT alisonmdunning sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT miriamdwek sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT dianameccles sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT christopherkedlund sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT dignarvelezedwards sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT carolinaellberg sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT dgarethevans sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT peterafasching sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT robertlferris sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT triantafillosliloglou sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT janecfigueiredo sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT oliviafletcher sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT reneetfortner sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT florentiafostira sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT silviafranceschi sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT eitanfriedman sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT stevenjgallinger sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT patriciaaganz sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT judygarber sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT joseagarciasaenz sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT simonagayther sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT grahamggiles sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT andrewkgodwin sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT marksgoldberg sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT davidegoldgar sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT ellenlgoode sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT marctgoodman sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT garygoodman sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT kjellgrankvist sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT markhgreene sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT henrikgronberg sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT jacekgronwald sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT pascalguenel sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT niclashakansson sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT perhall sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT utehamann sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT freddiechamdy sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT robertjhamilton sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT jochenhampe sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT aagehaugen sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT florianheitz sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT rolandoherrero sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT peterhillemanns sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT michaelhoffmeister sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT estridhøgdall sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT yunchulhong sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT johnlhopper sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT richardhoulston sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT peterjhulick sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT davidjhunter sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT davidghuntsman sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT gregoryidos sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT evgenynimyanitov sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT sueanningles sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT claudineisaacs sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT annajakubowska sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT pauljames sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT markajenkins sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT mattiasjohansson sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT mikaeljohansson sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT esthermjohn sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT amitdjoshi sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT radkakaneva sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT bethykarlan sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT lindaekelemen sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT tabeakuhl sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT kayteekhaw sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT elzakhusnutdinova sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT adamskibel sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT lambertusakiemeney sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT jerikim sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT susannekkjaer sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT juliaaknight sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT manoliskogevinas sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT zsofiakotejarai sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT stellakoutros sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT vesselankristensen sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT jolantakupryjanczyk sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT martinlacko sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT stephanlam sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT dietherlambrechts sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT mariateresalandi sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT philiplazarus sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT nhudle sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT eunjunglee sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT flaviolejbkowicz sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT heinzjoseflenz sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT goskaleslie sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT davorlessel sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT jennylester sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT douglasalevine sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT lili sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT christopherili sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT annikalindblom sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT noralanemlindor sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT geoffreyliu sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT fotiosloupakis sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT janlubinski sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT lovisemaehle sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT christianemaier sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT artomannermaa sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT loiclemarchand sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT saramargolin sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT taymaamay sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT lesleymcguffog sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT alfonsmeindl sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT poojamiddha sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT austinmiller sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT rogerlmilne sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT robertjmacinnis sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT francesmarymodugno sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT marcomontagna sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT victormoreno sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT kirstenbmoysich sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT loreleimucci sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT kennethmuir sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT annamariemulligan sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT katherinelnathanson sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT davideneal sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT andrewrness sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT susanlneuhausen sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT helinevanlinna sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT pollyanewcomb sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT lisafnewcomb sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT finnciliusnielsen sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT lienenikitinazake sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT børgegnordestgaard sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT robertlnussbaum sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT kennethoffit sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT editholah sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT aliaminalolama sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT olufunmilayoiolopade sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT andrewfolshan sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT hakanolsson sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT anaosorio sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT hardevpandha sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT jongypark sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT norapashayan sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT michaeltparsons sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT tanjapejovic sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT kathrynlpenney sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT wilberthmpeters sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT catherinemphelan sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT amandaiphipps sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT dijanaplaseskakaranfilska sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT mirandapring sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT daryaprokofyeva sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT paoloradice sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT karistefansson sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT susanjramus sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT leonraskin sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT gadrennert sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT hedysrennert sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT elizabethjvanrensburg sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT marjoriejriggan sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT harveyarisch sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT angelarisch sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT moniquejroobol sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT barrysrosenstein sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT maryannerossing sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT kimderuyck sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT emmanouilsaloustros sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT dalepsandler sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT elinorjsawyer sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT matthewbschabath sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT johannaschleutker sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT marjankakschmidt sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT vwendysetiawan sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT hongbingshen sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT erinmsiegel sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT weivasieh sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT christianfsinger sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT marthalslattery sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT karinadalsgaardsorensen sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT melissacsouthey sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT amandabspurdle sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT janetlstanford sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT victorialstevens sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT sebastianstintzing sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT jenniferstone sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT karinsundfeldt sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT rebeccasutphen sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT anthonyjswerdlow sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT eloizahtajara sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT catherinemtangen sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT adoninatardon sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT jackataylor sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT mdawnteare sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT manuelrteixeira sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT marybethterry sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT kathrynlterry sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT stephennthibodeau sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT madsthomassen sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT linebjørge sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT marctischkowitz sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT amandaetoland sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT dianatorres sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT paulatownsend sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT ruthctravis sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT nadinetung sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT shelleystworoger sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT corneliamulrich sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT nawaidusmani sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT celinemvachon sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT elsvannieuwenhuysen sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT anavega sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT migueleliasaguadobarrera sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT qinwang sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT penelopemwebb sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT claricerweinberg sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT stephanieweinstein sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT markcweissler sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT jeffreynweitzel sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT catharinemlwest sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT emilywhite sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT aliceswhittemore sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT herichwichmann sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT fredrikwiklund sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT robertwinqvist sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT alicjawolk sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT penellawoll sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT michaelwoods sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT annahwu sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT xifengwu sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT drakoulisyannoukakos sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT weizheng sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT shanbehzienolddiny sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT argyriosziogas sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT kristinkzorn sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT jacquelinemlane sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT richasaxena sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT duncanthomas sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT rayjeanjhung sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT brendadiergaarde sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT jamesmckay sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT ulrikepeters sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT lihsu sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT montserratgarciaclosas sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT rosalindaeeles sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT georgiachenevixtrench sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT pauljbrennan sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT christopherahaiman sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT jacquessimard sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT douglasfeaston sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT stephenbgruber sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT pauldppharoah sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT alkeslprice sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT bogdanpasaniuc sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT christopheriamos sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT peterkraft sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers AT saralindstrom sharedheritabilityandfunctionalenrichmentacrosssixsolidcancers
_version_	1718390320864952320
spelling	oai:doaj.org-article:b8cd2398d6804293b10da647205e97982021-12-02T14:40:21ZShared heritability and functional enrichment across six solid cancers10.1038/s41467-018-08054-42041-1723https://doaj.org/article/b8cd2398d6804293b10da647205e97982019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08054-4https://doaj.org/toc/2041-1723Similarities in cancers can be studied to interrogate their etiology. Here, the authors use genome-wide association study summary statistics from six cancer types based on 296,215 cases and 301,319 controls of European ancestry, showing that solid tumours arising from different tissues share a degree of common germline genetic basis.Xia JiangHilary K. FinucaneFredrick R. SchumacherStephanie L. SchmitJonathan P. TyrerYounghun HanKyriaki MichailidouCorina LesseurKaroline B. KuchenbaeckerJoe DennisDavid V. ContiGraham CaseyMia M. GaudetJeroen R. HuygheDemetrius AlbanesMelinda C. AldrichAngeline S. AndrewIrene L. AndrulisHoda Anton-CulverAntonis C. AntoniouNatalia N. AntonenkovaSusanne M. ArnoldKristan J. AronsonBanu K. ArunElisa V. BanderaRosa B. BarkardottirDaniel R. BarnesJyotsna BatraMatthias W. BeckmannJavier BenitezSara BenllochAndrew BerchuckSonja I. BerndtHeike BickeböllerStephanie A. BienCarl BlomqvistStefania BocciaNatalia V. BogdanovaStig E. BojesenManjeet K. BollaHiltrud BrauchHermann BrennerJames D. BrentonMark N. BrookJoan BrunetHans BrunnströmDaniel D. BuchananBarbara BurwinkelRalf ButzowGabriella CadoniTrinidad CaldésMaria A. CaligoIan CampbellPeter T. CampbellGéraldine Cancel-TassinLisa Cannon-AlbrightDaniele CampaNeil CaporasoAndré L. CarvalhoAndrew T. ChanJenny Chang-ClaudeStephen J. ChanockChu ChenDavid C. ChristianiKathleen B. M. ClaesFrank ClaessensJudith ClementsJ. Margriet ColléeMarcia Cruz CorreaFergus J. CouchAngela CoxJulie M. CunninghamCezary CybulskiKamila CzeneMary B. DalyAnna deFazioPeter DevileeOrland DiezManuela Gago-DominguezJenny L. DonovanThilo DörkEric J. DuellAlison M. DunningMiriam DwekDiana M. EcclesChristopher K. EdlundDigna R Velez EdwardsCarolina EllbergD. Gareth EvansPeter A. FaschingRobert L. FerrisTriantafillos LiloglouJane C. FigueiredoOlivia FletcherRenée T. FortnerFlorentia FostiraSilvia FranceschiEitan FriedmanSteven J. GallingerPatricia A. GanzJudy GarberJosé A. García-SáenzSimon A. GaytherGraham G. GilesAndrew K. GodwinMark S. GoldbergDavid E. GoldgarEllen L. GoodeMarc T. GoodmanGary GoodmanKjell GrankvistMark H. GreeneHenrik GronbergJacek GronwaldPascal GuénelNiclas HåkanssonPer HallUte HamannFreddie C. HamdyRobert J. HamiltonJochen HampeAage HaugenFlorian HeitzRolando HerreroPeter HillemannsMichael HoffmeisterEstrid HøgdallYun-Chul HongJohn L. HopperRichard HoulstonPeter J. HulickDavid J. HunterDavid G. HuntsmanGregory IdosEvgeny N. ImyanitovSue Ann InglesClaudine IsaacsAnna JakubowskaPaul JamesMark A. JenkinsMattias JohanssonMikael JohanssonEsther M. JohnAmit D. JoshiRadka KanevaBeth Y. KarlanLinda E. KelemenTabea KühlKay-Tee KhawElza KhusnutdinovaAdam S. KibelLambertus A. KiemeneyJeri KimSusanne K. KjaerJulia A. KnightManolis KogevinasZsofia Kote-JaraiStella KoutrosVessela N. KristensenJolanta KupryjanczykMartin LackoStephan LamDiether LambrechtsMaria Teresa LandiPhilip LazarusNhu D. LeEunjung LeeFlavio LejbkowiczHeinz-Josef LenzGoska LeslieDavor LesselJenny LesterDouglas A. LevineLi LiChristopher I. LiAnnika LindblomNoralane M. LindorGeoffrey LiuFotios LoupakisJan LubińskiLovise MaehleChristiane MaierArto MannermaaLoic Le MarchandSara MargolinTaymaa MayLesley McGuffogAlfons MeindlPooja MiddhaAustin MillerRoger L. MilneRobert J. MacInnisFrancesmary ModugnoMarco MontagnaVictor MorenoKirsten B. MoysichLorelei MucciKenneth MuirAnna Marie MulliganKatherine L. NathansonDavid E. NealAndrew R. NessSusan L. NeuhausenHeli NevanlinnaPolly A. NewcombLisa F. NewcombFinn Cilius NielsenLiene Nikitina-ZakeBørge G. NordestgaardRobert L. NussbaumKenneth OffitEdith OlahAli Amin Al OlamaOlufunmilayo I. OlopadeAndrew F. OlshanHåkan OlssonAna OsorioHardev PandhaJong Y. ParkNora PashayanMichael T. ParsonsTanja PejovicKathryn L. PenneyWilbert H M. PetersCatherine M. PhelanAmanda I. PhippsDijana Plaseska-KaranfilskaMiranda PringDarya ProkofyevaPaolo RadiceKari StefanssonSusan J. RamusLeon RaskinGad RennertHedy S. RennertElizabeth J. van RensburgMarjorie J. RigganHarvey A. RischAngela RischMonique J. RoobolBarry S. RosensteinMary Anne RossingKim De RuyckEmmanouil SaloustrosDale P. SandlerElinor J. SawyerMatthew B. SchabathJohanna SchleutkerMarjanka K. SchmidtV. Wendy SetiawanHongbing ShenErin M. SiegelWeiva SiehChristian F. SingerMartha L. SlatteryKarina Dalsgaard SorensenMelissa C. SoutheyAmanda B. SpurdleJanet L. StanfordVictoria L. StevensSebastian StintzingJennifer StoneKarin SundfeldtRebecca SutphenAnthony J. SwerdlowEloiza H. TajaraCatherine M. TangenAdonina TardonJack A. TaylorM. Dawn TeareManuel R. TeixeiraMary Beth TerryKathryn L. TerryStephen N. ThibodeauMads ThomassenLine BjørgeMarc TischkowitzAmanda E. TolandDiana TorresPaul A. TownsendRuth C. TravisNadine TungShelley S. TworogerCornelia M. UlrichNawaid UsmaniCeline M. VachonEls Van NieuwenhuysenAna VegaMiguel Elías Aguado-BarreraQin WangPenelope M. WebbClarice R. WeinbergStephanie WeinsteinMark C. WeisslerJeffrey N. WeitzelCatharine M. L. WestEmily WhiteAlice S. WhittemoreH-Erich WichmannFredrik WiklundRobert WinqvistAlicja WolkPenella WollMichael WoodsAnna H. WuXifeng WuDrakoulis YannoukakosWei ZhengShanbeh ZienolddinyArgyrios ZiogasKristin K. ZornJacqueline M. LaneRicha SaxenaDuncan ThomasRayjean J. HungBrenda DiergaardeJames McKayUlrike PetersLi HsuMontserrat García-ClosasRosalind A. EelesGeorgia Chenevix-TrenchPaul J. BrennanChristopher A. HaimanJacques SimardDouglas F. EastonStephen B. GruberPaul D. P. PharoahAlkes L. PriceBogdan PasaniucChristopher I. AmosPeter KraftSara LindströmNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-23 (2019)

Shared heritability and functional enrichment across six solid cancers

Ejemplares similares