The preparation of 3,5-dihydroxy-4-isopropylstilbene nanoemulsion and in vitro release

Yue Zhang1,2, Jungang Gao1, Hetang Zheng2, Ran Zhang3, Yucui Han21College of Chemistry and Enviromental Science, Hebei University, Baoding, China; 2School of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, China; 3College of Chemical Engineering, Ea...

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Autores principales:	Zhang Y, Gao JG, Zheng HT, Zhang R, Han YC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b8cddd42232a467ca8bb6bd843eac7df
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spelling	oai:doaj.org-article:b8cddd42232a467ca8bb6bd843eac7df2021-12-02T03:03:58ZThe preparation of 3,5-dihydroxy-4-isopropylstilbene nanoemulsion and in vitro release1176-91141178-2013https://doaj.org/article/b8cddd42232a467ca8bb6bd843eac7df2011-04-01T00:00:00Zhttp://www.dovepress.com/the-preparation-of-35-dihydroxy-4-isopropylstilbene-nanoemulsion-and-i-a6935https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Yue Zhang1,2, Jungang Gao1, Hetang Zheng2, Ran Zhang3, Yucui Han21College of Chemistry and Enviromental Science, Hebei University, Baoding, China; 2School of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, China; 3College of Chemical Engineering, East China University of Science and Technology, Shanghai, ChinaAbstract: We have reported a novel procedure to prepare 3,5-dihydroxy-4-isopropylstilbene (DHPS) nanoemulsion, using a low-energy emulsification method. Based on the phase diagram, the optimum prescription of nanoemulsion preparation was screened. With polyoxyethylenated castor oil (EL-40) as the surfactant, ethanol as the co-surfactant, and isopropyl myristate (IPM) as the oil phase, the DHPS nanoemulsion was obtained with a transparent appearance, little viscosity, and spherically uniform distribution verified by transmission electron microscopy and laser scattering analyzer. The nanoemulsion was also determined by FT-Raman spectroscopy. The DHPS nanoemulsion demonstrated good stability and stable physical and chemical properties. The nanoemulsion dramatically improved the transdermal release of DHPS (from 8.02 &micro;g&nbsp;&middot; cm-2 to 273.15 &micro;g&nbsp;&middot; cm-2) and could become a favorable new dosage form for DHPS.Keywords: nanoemulsion, 3,5-dihydroxy-4-isopropylstilbene, DHPS, pseudo-ternary phase diagram Zhang YGao JGZheng HTZhang RHan YCDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 649-657 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Zhang Y Gao JG Zheng HT Zhang R Han YC The preparation of 3,5-dihydroxy-4-isopropylstilbene nanoemulsion and in vitro release
description	Yue Zhang1,2, Jungang Gao1, Hetang Zheng2, Ran Zhang3, Yucui Han21College of Chemistry and Enviromental Science, Hebei University, Baoding, China; 2School of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, China; 3College of Chemical Engineering, East China University of Science and Technology, Shanghai, ChinaAbstract: We have reported a novel procedure to prepare 3,5-dihydroxy-4-isopropylstilbene (DHPS) nanoemulsion, using a low-energy emulsification method. Based on the phase diagram, the optimum prescription of nanoemulsion preparation was screened. With polyoxyethylenated castor oil (EL-40) as the surfactant, ethanol as the co-surfactant, and isopropyl myristate (IPM) as the oil phase, the DHPS nanoemulsion was obtained with a transparent appearance, little viscosity, and spherically uniform distribution verified by transmission electron microscopy and laser scattering analyzer. The nanoemulsion was also determined by FT-Raman spectroscopy. The DHPS nanoemulsion demonstrated good stability and stable physical and chemical properties. The nanoemulsion dramatically improved the transdermal release of DHPS (from 8.02 &micro;g&nbsp;&middot; cm-2 to 273.15 &micro;g&nbsp;&middot; cm-2) and could become a favorable new dosage form for DHPS.Keywords: nanoemulsion, 3,5-dihydroxy-4-isopropylstilbene, DHPS, pseudo-ternary phase diagram
format	article
author	Zhang Y Gao JG Zheng HT Zhang R Han YC
author_facet	Zhang Y Gao JG Zheng HT Zhang R Han YC
author_sort	Zhang Y
title	The preparation of 3,5-dihydroxy-4-isopropylstilbene nanoemulsion and in vitro release
title_short	The preparation of 3,5-dihydroxy-4-isopropylstilbene nanoemulsion and in vitro release
title_full	The preparation of 3,5-dihydroxy-4-isopropylstilbene nanoemulsion and in vitro release
title_fullStr	The preparation of 3,5-dihydroxy-4-isopropylstilbene nanoemulsion and in vitro release
title_full_unstemmed	The preparation of 3,5-dihydroxy-4-isopropylstilbene nanoemulsion and in vitro release
title_sort	preparation of 3,5-dihydroxy-4-isopropylstilbene nanoemulsion and in vitro release
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/b8cddd42232a467ca8bb6bd843eac7df
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The preparation of 3,5-dihydroxy-4-isopropylstilbene nanoemulsion and in vitro release

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