Diverse inhibitory projections from the cerebellar interposed nucleus

The cerebellum consists of parallel circuit modules that contribute to diverse behaviors, spanning motor to cognitive. Recent work employing cell-type-specific tracing has identified circumscribed output channels of the cerebellar nuclei (CbN) that could confer tight functional specificity. These st...

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Autores principales:	Elena N Judd, Samantha M Lewis, Abigail L Person
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	cerebellum inferior olive circuits Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b8d0c06216904f2ba19207a0ca8fa0cf
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spelling	oai:doaj.org-article:b8d0c06216904f2ba19207a0ca8fa0cf2021-11-17T10:53:56ZDiverse inhibitory projections from the cerebellar interposed nucleus10.7554/eLife.662312050-084Xe66231https://doaj.org/article/b8d0c06216904f2ba19207a0ca8fa0cf2021-09-01T00:00:00Zhttps://elifesciences.org/articles/66231https://doaj.org/toc/2050-084XThe cerebellum consists of parallel circuit modules that contribute to diverse behaviors, spanning motor to cognitive. Recent work employing cell-type-specific tracing has identified circumscribed output channels of the cerebellar nuclei (CbN) that could confer tight functional specificity. These studies have largely focused on excitatory projections of the CbN, however, leaving open the question of whether inhibitory neurons also constitute multiple output modules. We mapped output and input patterns to intersectionally restricted cell types of the interposed and adjacent interstitial nuclei in mice. In contrast to the widespread assumption of primarily excitatory outputs and restricted inferior olive-targeting inhibitory output, we found that inhibitory neurons from this region ramified widely within the brainstem, targeting both motor- and sensory-related nuclei, distinct from excitatory output targets. Despite differences in output targeting, monosynaptic rabies tracing revealed largely shared afferents to both cell classes. We discuss the potential novel functional roles for inhibitory outputs in the context of cerebellar theory.Elena N JuddSamantha M LewisAbigail L PersoneLife Sciences Publications Ltdarticlecerebelluminferior olivecircuitsMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cerebellum inferior olive circuits Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	cerebellum inferior olive circuits Medicine R Science Q Biology (General) QH301-705.5 Elena N Judd Samantha M Lewis Abigail L Person Diverse inhibitory projections from the cerebellar interposed nucleus
description	The cerebellum consists of parallel circuit modules that contribute to diverse behaviors, spanning motor to cognitive. Recent work employing cell-type-specific tracing has identified circumscribed output channels of the cerebellar nuclei (CbN) that could confer tight functional specificity. These studies have largely focused on excitatory projections of the CbN, however, leaving open the question of whether inhibitory neurons also constitute multiple output modules. We mapped output and input patterns to intersectionally restricted cell types of the interposed and adjacent interstitial nuclei in mice. In contrast to the widespread assumption of primarily excitatory outputs and restricted inferior olive-targeting inhibitory output, we found that inhibitory neurons from this region ramified widely within the brainstem, targeting both motor- and sensory-related nuclei, distinct from excitatory output targets. Despite differences in output targeting, monosynaptic rabies tracing revealed largely shared afferents to both cell classes. We discuss the potential novel functional roles for inhibitory outputs in the context of cerebellar theory.
format	article
author	Elena N Judd Samantha M Lewis Abigail L Person
author_facet	Elena N Judd Samantha M Lewis Abigail L Person
author_sort	Elena N Judd
title	Diverse inhibitory projections from the cerebellar interposed nucleus
title_short	Diverse inhibitory projections from the cerebellar interposed nucleus
title_full	Diverse inhibitory projections from the cerebellar interposed nucleus
title_fullStr	Diverse inhibitory projections from the cerebellar interposed nucleus
title_full_unstemmed	Diverse inhibitory projections from the cerebellar interposed nucleus
title_sort	diverse inhibitory projections from the cerebellar interposed nucleus
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/b8d0c06216904f2ba19207a0ca8fa0cf
work_keys_str_mv	AT elenanjudd diverseinhibitoryprojectionsfromthecerebellarinterposednucleus AT samanthamlewis diverseinhibitoryprojectionsfromthecerebellarinterposednucleus AT abigaillperson diverseinhibitoryprojectionsfromthecerebellarinterposednucleus
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Diverse inhibitory projections from the cerebellar interposed nucleus

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