Gathering and exploring scientific knowledge in pharmacovigilance.

Pharmacovigilance plays a key role in the healthcare domain through the assessment, monitoring and discovery of interactions amongst drugs and their effects in the human organism. However, technological advances in this field have been slowing down over the last decade due to miscellaneous legal, et...

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Autores principales:	Pedro Lopes, Tiago Nunes, David Campos, Laura Ines Furlong, Anna Bauer-Mehren, Ferran Sanz, Maria Carmen Carrascosa, Jordi Mestres, Jan Kors, Bharat Singh, Erik van Mulligen, Johan Van der Lei, Gayo Diallo, Paul Avillach, Ernst Ahlberg, Scott Boyer, Carlos Diaz, José Luís Oliveira
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b8d3c88ad84a4bb2a59476df4ccc6583
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spelling	oai:doaj.org-article:b8d3c88ad84a4bb2a59476df4ccc65832021-11-18T08:42:22ZGathering and exploring scientific knowledge in pharmacovigilance.1932-620310.1371/journal.pone.0083016https://doaj.org/article/b8d3c88ad84a4bb2a59476df4ccc65832013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24349421/?tool=EBIhttps://doaj.org/toc/1932-6203Pharmacovigilance plays a key role in the healthcare domain through the assessment, monitoring and discovery of interactions amongst drugs and their effects in the human organism. However, technological advances in this field have been slowing down over the last decade due to miscellaneous legal, ethical and methodological constraints. Pharmaceutical companies started to realize that collaborative and integrative approaches boost current drug research and development processes. Hence, new strategies are required to connect researchers, datasets, biomedical knowledge and analysis algorithms, allowing them to fully exploit the true value behind state-of-the-art pharmacovigilance efforts. This manuscript introduces a new platform directed towards pharmacovigilance knowledge providers. This system, based on a service-oriented architecture, adopts a plugin-based approach to solve fundamental pharmacovigilance software challenges. With the wealth of collected clinical and pharmaceutical data, it is now possible to connect knowledge providers' analysis and exploration algorithms with real data. As a result, new strategies allow a faster identification of high-risk interactions between marketed drugs and adverse events, and enable the automated uncovering of scientific evidence behind them. With this architecture, the pharmacovigilance field has a new platform to coordinate large-scale drug evaluation efforts in a unique ecosystem, publicly available at http://bioinformatics.ua.pt/euadr/.Pedro LopesTiago NunesDavid CamposLaura Ines FurlongAnna Bauer-MehrenFerran SanzMaria Carmen CarrascosaJordi MestresJan KorsBharat SinghErik van MulligenJohan Van der LeiGayo DialloPaul AvillachErnst AhlbergScott BoyerCarlos DiazJosé Luís OliveiraPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e83016 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pedro Lopes Tiago Nunes David Campos Laura Ines Furlong Anna Bauer-Mehren Ferran Sanz Maria Carmen Carrascosa Jordi Mestres Jan Kors Bharat Singh Erik van Mulligen Johan Van der Lei Gayo Diallo Paul Avillach Ernst Ahlberg Scott Boyer Carlos Diaz José Luís Oliveira Gathering and exploring scientific knowledge in pharmacovigilance.
description	Pharmacovigilance plays a key role in the healthcare domain through the assessment, monitoring and discovery of interactions amongst drugs and their effects in the human organism. However, technological advances in this field have been slowing down over the last decade due to miscellaneous legal, ethical and methodological constraints. Pharmaceutical companies started to realize that collaborative and integrative approaches boost current drug research and development processes. Hence, new strategies are required to connect researchers, datasets, biomedical knowledge and analysis algorithms, allowing them to fully exploit the true value behind state-of-the-art pharmacovigilance efforts. This manuscript introduces a new platform directed towards pharmacovigilance knowledge providers. This system, based on a service-oriented architecture, adopts a plugin-based approach to solve fundamental pharmacovigilance software challenges. With the wealth of collected clinical and pharmaceutical data, it is now possible to connect knowledge providers' analysis and exploration algorithms with real data. As a result, new strategies allow a faster identification of high-risk interactions between marketed drugs and adverse events, and enable the automated uncovering of scientific evidence behind them. With this architecture, the pharmacovigilance field has a new platform to coordinate large-scale drug evaluation efforts in a unique ecosystem, publicly available at http://bioinformatics.ua.pt/euadr/.
format	article
author	Pedro Lopes Tiago Nunes David Campos Laura Ines Furlong Anna Bauer-Mehren Ferran Sanz Maria Carmen Carrascosa Jordi Mestres Jan Kors Bharat Singh Erik van Mulligen Johan Van der Lei Gayo Diallo Paul Avillach Ernst Ahlberg Scott Boyer Carlos Diaz José Luís Oliveira
author_facet	Pedro Lopes Tiago Nunes David Campos Laura Ines Furlong Anna Bauer-Mehren Ferran Sanz Maria Carmen Carrascosa Jordi Mestres Jan Kors Bharat Singh Erik van Mulligen Johan Van der Lei Gayo Diallo Paul Avillach Ernst Ahlberg Scott Boyer Carlos Diaz José Luís Oliveira
author_sort	Pedro Lopes
title	Gathering and exploring scientific knowledge in pharmacovigilance.
title_short	Gathering and exploring scientific knowledge in pharmacovigilance.
title_full	Gathering and exploring scientific knowledge in pharmacovigilance.
title_fullStr	Gathering and exploring scientific knowledge in pharmacovigilance.
title_full_unstemmed	Gathering and exploring scientific knowledge in pharmacovigilance.
title_sort	gathering and exploring scientific knowledge in pharmacovigilance.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/b8d3c88ad84a4bb2a59476df4ccc6583
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Gathering and exploring scientific knowledge in pharmacovigilance.

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