Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones

Combining genome mining and heterologous expression in a genetically tractable host can lead to bioactive natural products discovery and production. Here, the authors employ this strategy for new decalin-containing diterpenoid pyrenes production by expressing native, extended, and shunt pathways in...

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Autores principales:	Kento Tsukada, Shono Shinki, Akiho Kaneko, Kazuma Murakami, Kazuhiro Irie, Masatoshi Murai, Hideto Miyoshi, Shingo Dan, Kumi Kawaji, Hironori Hayashi, Eiichi N. Kodama, Aki Hori, Emil Salim, Takayuki Kuraishi, Naoya Hirata, Yasunari Kanda, Teigo Asai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b8d5d9bdb0c848689511d663ed7160bb
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spelling	oai:doaj.org-article:b8d5d9bdb0c848689511d663ed7160bb2021-12-02T16:56:32ZSynthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones10.1038/s41467-020-15664-42041-1723https://doaj.org/article/b8d5d9bdb0c848689511d663ed7160bb2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15664-4https://doaj.org/toc/2041-1723Combining genome mining and heterologous expression in a genetically tractable host can lead to bioactive natural products discovery and production. Here, the authors employ this strategy for new decalin-containing diterpenoid pyrenes production by expressing native, extended, and shunt pathways in Aspergillus oryzae.Kento TsukadaShono ShinkiAkiho KanekoKazuma MurakamiKazuhiro IrieMasatoshi MuraiHideto MiyoshiShingo DanKumi KawajiHironori HayashiEiichi N. KodamaAki HoriEmil SalimTakayuki KuraishiNaoya HirataYasunari KandaTeigo AsaiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kento Tsukada Shono Shinki Akiho Kaneko Kazuma Murakami Kazuhiro Irie Masatoshi Murai Hideto Miyoshi Shingo Dan Kumi Kawaji Hironori Hayashi Eiichi N. Kodama Aki Hori Emil Salim Takayuki Kuraishi Naoya Hirata Yasunari Kanda Teigo Asai Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones
description	Combining genome mining and heterologous expression in a genetically tractable host can lead to bioactive natural products discovery and production. Here, the authors employ this strategy for new decalin-containing diterpenoid pyrenes production by expressing native, extended, and shunt pathways in Aspergillus oryzae.
format	article
author	Kento Tsukada Shono Shinki Akiho Kaneko Kazuma Murakami Kazuhiro Irie Masatoshi Murai Hideto Miyoshi Shingo Dan Kumi Kawaji Hironori Hayashi Eiichi N. Kodama Aki Hori Emil Salim Takayuki Kuraishi Naoya Hirata Yasunari Kanda Teigo Asai
author_facet	Kento Tsukada Shono Shinki Akiho Kaneko Kazuma Murakami Kazuhiro Irie Masatoshi Murai Hideto Miyoshi Shingo Dan Kumi Kawaji Hironori Hayashi Eiichi N. Kodama Aki Hori Emil Salim Takayuki Kuraishi Naoya Hirata Yasunari Kanda Teigo Asai
author_sort	Kento Tsukada
title	Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones
title_short	Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones
title_full	Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones
title_fullStr	Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones
title_full_unstemmed	Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones
title_sort	synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b8d5d9bdb0c848689511d663ed7160bb
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Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones

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