Prospects for the use of a drug based on a complex of fatty acid esters in models of laboratory animals in vivo

In this work we carried out studies of the first obtained micellar composition of fatty acid esters with allantoin on a water basis to determine its local irritant effect and therapeutic efficacy in the treatment of burns. It was found that there was a sequential change in the phases of the burn wou...

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Autores principales:	Smirnova K.Yu., Bannikova A.V., Kozlov S.V., Romanova O.V.
Formato:	article
Lenguaje:	EN FR
Publicado:	EDP Sciences 2021
Materias:	Microbiology QR1-502 Physiology QP1-981 Zoology QL1-991
Acceso en línea:	https://doaj.org/article/b8d668ee97c84a418c8e971e6403459d
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spelling	oai:doaj.org-article:b8d668ee97c84a418c8e971e6403459d2021-11-08T15:17:24ZProspects for the use of a drug based on a complex of fatty acid esters in models of laboratory animals in vivo2117-445810.1051/bioconf/20213700175https://doaj.org/article/b8d668ee97c84a418c8e971e6403459d2021-01-01T00:00:00Zhttps://www.bio-conferences.org/articles/bioconf/pdf/2021/09/bioconf_fies2021_00175.pdfhttps://doaj.org/toc/2117-4458In this work we carried out studies of the first obtained micellar composition of fatty acid esters with allantoin on a water basis to determine its local irritant effect and therapeutic efficacy in the treatment of burns. It was found that there was a sequential change in the phases of the burn wound process in all groups. During the observation period, wound suppuration was not observed; there were 4 cases of a complicated course of the wound process and a fatal outcome in the control group. When conducting studies of local irritant effects, the assessment was carried out in points, in the experimental group it was on average 2 points as for the animals of the control group. The conducted studies allow us to conclude that the drug, when applied to the skin according to the interstate standard GOST ISO 10993-10—2011, has a weak degree of response to irritation in guinea pigs. The application of a permissive dose of the drug to sensitized guinea pigs does not cause a response from the skin, which indicates the absence of allergenic properties in this composition.Smirnova K.Yu.Bannikova A.V.Kozlov S.V.Romanova O.V.EDP SciencesarticleMicrobiologyQR1-502PhysiologyQP1-981ZoologyQL1-991ENFRBIO Web of Conferences, Vol 37, p 00175 (2021)
institution	DOAJ
collection	DOAJ
language	EN FR
topic	Microbiology QR1-502 Physiology QP1-981 Zoology QL1-991
spellingShingle	Microbiology QR1-502 Physiology QP1-981 Zoology QL1-991 Smirnova K.Yu. Bannikova A.V. Kozlov S.V. Romanova O.V. Prospects for the use of a drug based on a complex of fatty acid esters in models of laboratory animals in vivo
description	In this work we carried out studies of the first obtained micellar composition of fatty acid esters with allantoin on a water basis to determine its local irritant effect and therapeutic efficacy in the treatment of burns. It was found that there was a sequential change in the phases of the burn wound process in all groups. During the observation period, wound suppuration was not observed; there were 4 cases of a complicated course of the wound process and a fatal outcome in the control group. When conducting studies of local irritant effects, the assessment was carried out in points, in the experimental group it was on average 2 points as for the animals of the control group. The conducted studies allow us to conclude that the drug, when applied to the skin according to the interstate standard GOST ISO 10993-10—2011, has a weak degree of response to irritation in guinea pigs. The application of a permissive dose of the drug to sensitized guinea pigs does not cause a response from the skin, which indicates the absence of allergenic properties in this composition.
format	article
author	Smirnova K.Yu. Bannikova A.V. Kozlov S.V. Romanova O.V.
author_facet	Smirnova K.Yu. Bannikova A.V. Kozlov S.V. Romanova O.V.
author_sort	Smirnova K.Yu.
title	Prospects for the use of a drug based on a complex of fatty acid esters in models of laboratory animals in vivo
title_short	Prospects for the use of a drug based on a complex of fatty acid esters in models of laboratory animals in vivo
title_full	Prospects for the use of a drug based on a complex of fatty acid esters in models of laboratory animals in vivo
title_fullStr	Prospects for the use of a drug based on a complex of fatty acid esters in models of laboratory animals in vivo
title_full_unstemmed	Prospects for the use of a drug based on a complex of fatty acid esters in models of laboratory animals in vivo
title_sort	prospects for the use of a drug based on a complex of fatty acid esters in models of laboratory animals in vivo
publisher	EDP Sciences
publishDate	2021
url	https://doaj.org/article/b8d668ee97c84a418c8e971e6403459d
work_keys_str_mv	AT smirnovakyu prospectsfortheuseofadrugbasedonacomplexoffattyacidestersinmodelsoflaboratoryanimalsinvivo AT bannikovaav prospectsfortheuseofadrugbasedonacomplexoffattyacidestersinmodelsoflaboratoryanimalsinvivo AT kozlovsv prospectsfortheuseofadrugbasedonacomplexoffattyacidestersinmodelsoflaboratoryanimalsinvivo AT romanovaov prospectsfortheuseofadrugbasedonacomplexoffattyacidestersinmodelsoflaboratoryanimalsinvivo
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Prospects for the use of a drug based on a complex of fatty acid esters in models of laboratory animals in vivo

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