Functional and structural network impairment in childhood frontal lobe epilepsy.

In childhood frontal lobe epilepsy (FLE), cognitive impairment and educational underachievement are serious, well-known co-morbidities. The broad scale of affected cognitive domains suggests wide-spread network disturbances that not only involves, but also extends beyond the frontal lobe. In this st...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Maarten J Vaessen, Jacobus F A Jansen, Hilde M H Braakman, Paul A M Hofman, Anton De Louw, Albert P Aldenkamp, Walter H Backes
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b8d6991917ff4d6ca4dd23772e125327
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b8d6991917ff4d6ca4dd23772e125327
record_format	dspace
spelling	oai:doaj.org-article:b8d6991917ff4d6ca4dd23772e1253272021-11-18T08:29:52ZFunctional and structural network impairment in childhood frontal lobe epilepsy.1932-620310.1371/journal.pone.0090068https://doaj.org/article/b8d6991917ff4d6ca4dd23772e1253272014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24594874/?tool=EBIhttps://doaj.org/toc/1932-6203In childhood frontal lobe epilepsy (FLE), cognitive impairment and educational underachievement are serious, well-known co-morbidities. The broad scale of affected cognitive domains suggests wide-spread network disturbances that not only involves, but also extends beyond the frontal lobe. In this study we have investigated whole brain connectional properties of children with FLE in relation to their cognitive impairment and compared them with healthy controls. Functional connectivity (FC) of the networks was derived from dynamic fluctuations of resting state fMRI and structural connectivity (SC) was obtained from fiber tractograms of diffusion weighted MRI. The whole brain network was characterized with graph theoretical metrics and decomposed into modules. Subsequently, the graph metrics and the connectivity within and between modules were related to cognitive performance. Functional network disturbances in FLE were related to increased clustering, increased path length, and stronger modularity compared to healthy controls, which was accompanied by stronger within- and weaker between-module functional connectivity. Although structural path length and clustering appeared normal in children with FLE, structural modularity increased with stronger cognitive impairment. It is concluded that decreased coupling between large-scale functional network modules is a hallmark for impaired cognition in childhood FLE.Maarten J VaessenJacobus F A JansenHilde M H BraakmanPaul A M HofmanAnton De LouwAlbert P AldenkampWalter H BackesPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 3, p e90068 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maarten J Vaessen Jacobus F A Jansen Hilde M H Braakman Paul A M Hofman Anton De Louw Albert P Aldenkamp Walter H Backes Functional and structural network impairment in childhood frontal lobe epilepsy.
description	In childhood frontal lobe epilepsy (FLE), cognitive impairment and educational underachievement are serious, well-known co-morbidities. The broad scale of affected cognitive domains suggests wide-spread network disturbances that not only involves, but also extends beyond the frontal lobe. In this study we have investigated whole brain connectional properties of children with FLE in relation to their cognitive impairment and compared them with healthy controls. Functional connectivity (FC) of the networks was derived from dynamic fluctuations of resting state fMRI and structural connectivity (SC) was obtained from fiber tractograms of diffusion weighted MRI. The whole brain network was characterized with graph theoretical metrics and decomposed into modules. Subsequently, the graph metrics and the connectivity within and between modules were related to cognitive performance. Functional network disturbances in FLE were related to increased clustering, increased path length, and stronger modularity compared to healthy controls, which was accompanied by stronger within- and weaker between-module functional connectivity. Although structural path length and clustering appeared normal in children with FLE, structural modularity increased with stronger cognitive impairment. It is concluded that decreased coupling between large-scale functional network modules is a hallmark for impaired cognition in childhood FLE.
format	article
author	Maarten J Vaessen Jacobus F A Jansen Hilde M H Braakman Paul A M Hofman Anton De Louw Albert P Aldenkamp Walter H Backes
author_facet	Maarten J Vaessen Jacobus F A Jansen Hilde M H Braakman Paul A M Hofman Anton De Louw Albert P Aldenkamp Walter H Backes
author_sort	Maarten J Vaessen
title	Functional and structural network impairment in childhood frontal lobe epilepsy.
title_short	Functional and structural network impairment in childhood frontal lobe epilepsy.
title_full	Functional and structural network impairment in childhood frontal lobe epilepsy.
title_fullStr	Functional and structural network impairment in childhood frontal lobe epilepsy.
title_full_unstemmed	Functional and structural network impairment in childhood frontal lobe epilepsy.
title_sort	functional and structural network impairment in childhood frontal lobe epilepsy.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/b8d6991917ff4d6ca4dd23772e125327
work_keys_str_mv	AT maartenjvaessen functionalandstructuralnetworkimpairmentinchildhoodfrontallobeepilepsy AT jacobusfajansen functionalandstructuralnetworkimpairmentinchildhoodfrontallobeepilepsy AT hildemhbraakman functionalandstructuralnetworkimpairmentinchildhoodfrontallobeepilepsy AT paulamhofman functionalandstructuralnetworkimpairmentinchildhoodfrontallobeepilepsy AT antondelouw functionalandstructuralnetworkimpairmentinchildhoodfrontallobeepilepsy AT albertpaldenkamp functionalandstructuralnetworkimpairmentinchildhoodfrontallobeepilepsy AT walterhbackes functionalandstructuralnetworkimpairmentinchildhoodfrontallobeepilepsy
_version_	1718421766422921216

Functional and structural network impairment in childhood frontal lobe epilepsy.

Ejemplares similares