Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration

Prokineticin-2 (PK2) is a secreted protein involved in a number of physiological functions. Here, the authors find that PK2 expression increases in surviving DA neurons from Parkinson's disease patients, and show it protects against dopaminergic degeneration in PD mouse models.

Guardado en:

Detalles Bibliográficos
Autores principales:	Richard Gordon, Matthew L. Neal, Jie Luo, Monica R. Langley, Dilshan S. Harischandra, Nikhil Panicker, Adhithiya Charli, Huajun Jin, Vellareddy Anantharam, Trent M. Woodruff, Qun-Yong Zhou, Anumantha G. Kanthasamy, Arthi Kanthasamy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b8d6e03a18c04bd3a3c79b515e12e20f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b8d6e03a18c04bd3a3c79b515e12e20f
record_format	dspace
spelling	oai:doaj.org-article:b8d6e03a18c04bd3a3c79b515e12e20f2021-12-02T16:50:15ZProkineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration10.1038/ncomms129322041-1723https://doaj.org/article/b8d6e03a18c04bd3a3c79b515e12e20f2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms12932https://doaj.org/toc/2041-1723Prokineticin-2 (PK2) is a secreted protein involved in a number of physiological functions. Here, the authors find that PK2 expression increases in surviving DA neurons from Parkinson's disease patients, and show it protects against dopaminergic degeneration in PD mouse models.Richard GordonMatthew L. NealJie LuoMonica R. LangleyDilshan S. HarischandraNikhil PanickerAdhithiya CharliHuajun JinVellareddy AnantharamTrent M. WoodruffQun-Yong ZhouAnumantha G. KanthasamyArthi KanthasamyNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-18 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Richard Gordon Matthew L. Neal Jie Luo Monica R. Langley Dilshan S. Harischandra Nikhil Panicker Adhithiya Charli Huajun Jin Vellareddy Anantharam Trent M. Woodruff Qun-Yong Zhou Anumantha G. Kanthasamy Arthi Kanthasamy Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration
description	Prokineticin-2 (PK2) is a secreted protein involved in a number of physiological functions. Here, the authors find that PK2 expression increases in surviving DA neurons from Parkinson's disease patients, and show it protects against dopaminergic degeneration in PD mouse models.
format	article
author	Richard Gordon Matthew L. Neal Jie Luo Monica R. Langley Dilshan S. Harischandra Nikhil Panicker Adhithiya Charli Huajun Jin Vellareddy Anantharam Trent M. Woodruff Qun-Yong Zhou Anumantha G. Kanthasamy Arthi Kanthasamy
author_facet	Richard Gordon Matthew L. Neal Jie Luo Monica R. Langley Dilshan S. Harischandra Nikhil Panicker Adhithiya Charli Huajun Jin Vellareddy Anantharam Trent M. Woodruff Qun-Yong Zhou Anumantha G. Kanthasamy Arthi Kanthasamy
author_sort	Richard Gordon
title	Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration
title_short	Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration
title_full	Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration
title_fullStr	Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration
title_full_unstemmed	Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration
title_sort	prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/b8d6e03a18c04bd3a3c79b515e12e20f
work_keys_str_mv	AT richardgordon prokineticin2upregulationduringneuronalinjurymediatesacompensatoryprotectiveresponseagainstdopaminergicneuronaldegeneration AT matthewlneal prokineticin2upregulationduringneuronalinjurymediatesacompensatoryprotectiveresponseagainstdopaminergicneuronaldegeneration AT jieluo prokineticin2upregulationduringneuronalinjurymediatesacompensatoryprotectiveresponseagainstdopaminergicneuronaldegeneration AT monicarlangley prokineticin2upregulationduringneuronalinjurymediatesacompensatoryprotectiveresponseagainstdopaminergicneuronaldegeneration AT dilshansharischandra prokineticin2upregulationduringneuronalinjurymediatesacompensatoryprotectiveresponseagainstdopaminergicneuronaldegeneration AT nikhilpanicker prokineticin2upregulationduringneuronalinjurymediatesacompensatoryprotectiveresponseagainstdopaminergicneuronaldegeneration AT adhithiyacharli prokineticin2upregulationduringneuronalinjurymediatesacompensatoryprotectiveresponseagainstdopaminergicneuronaldegeneration AT huajunjin prokineticin2upregulationduringneuronalinjurymediatesacompensatoryprotectiveresponseagainstdopaminergicneuronaldegeneration AT vellareddyanantharam prokineticin2upregulationduringneuronalinjurymediatesacompensatoryprotectiveresponseagainstdopaminergicneuronaldegeneration AT trentmwoodruff prokineticin2upregulationduringneuronalinjurymediatesacompensatoryprotectiveresponseagainstdopaminergicneuronaldegeneration AT qunyongzhou prokineticin2upregulationduringneuronalinjurymediatesacompensatoryprotectiveresponseagainstdopaminergicneuronaldegeneration AT anumanthagkanthasamy prokineticin2upregulationduringneuronalinjurymediatesacompensatoryprotectiveresponseagainstdopaminergicneuronaldegeneration AT arthikanthasamy prokineticin2upregulationduringneuronalinjurymediatesacompensatoryprotectiveresponseagainstdopaminergicneuronaldegeneration
_version_	1718383062129049600

Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration

Ejemplares similares