Rationale and validation of a novel mobile application probing motor inhibition: Proof of concept of CALM-IT.

Identification of behavioral mechanisms underlying psychopathology is essential for the development of novel targeted therapeutics. However, this work relies on rigorous, time-intensive, clinic-based laboratory research, making it difficult to translate research paradigms into tools that can be used...

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Autores principales:	Elise M Cardinale, Reut Naim, Simone P Haller, Ramaris German, Christian Botz-Zapp, Jessica Bezek, David C Jangraw, Melissa A Brotman
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b8d7dd4a3f2b4ae1ade06f9129b6f1fe
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spelling	oai:doaj.org-article:b8d7dd4a3f2b4ae1ade06f9129b6f1fe2021-11-25T06:23:36ZRationale and validation of a novel mobile application probing motor inhibition: Proof of concept of CALM-IT.1932-620310.1371/journal.pone.0252245https://doaj.org/article/b8d7dd4a3f2b4ae1ade06f9129b6f1fe2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252245https://doaj.org/toc/1932-6203Identification of behavioral mechanisms underlying psychopathology is essential for the development of novel targeted therapeutics. However, this work relies on rigorous, time-intensive, clinic-based laboratory research, making it difficult to translate research paradigms into tools that can be used by clinicians in the community. The broad adoption of smartphone technology provides a promising opportunity to bridge the gap between the mechanisms identified in the laboratory and the clinical interventions targeting them in the community. The goal of the current study is to develop a developmentally appropriate, engaging, novel mobile application called CALM-IT that probes a narrow biologically informed process, inhibitory control. We aim to leverage the rigorous and robust methods traditionally used in laboratory settings to validate this novel mechanism-driven but easily disseminatable tool that can be used by clinicians to probe inhibitory control in the community. The development of CALM-IT has significant implications for the ability to screen for inhibitory control deficits in the community by both clinicians and researchers. By facilitating assessment of inhibitory control outside of the laboratory setting, researchers could have access to larger and more diverse samples. Additionally, in the clinical setting, CALM-IT represents a novel clinical screening measure that could be used to determine personalized courses of treatment based on the presence of inhibitory control deficits.Elise M CardinaleReut NaimSimone P HallerRamaris GermanChristian Botz-ZappJessica BezekDavid C JangrawMelissa A BrotmanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0252245 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elise M Cardinale Reut Naim Simone P Haller Ramaris German Christian Botz-Zapp Jessica Bezek David C Jangraw Melissa A Brotman Rationale and validation of a novel mobile application probing motor inhibition: Proof of concept of CALM-IT.
description	Identification of behavioral mechanisms underlying psychopathology is essential for the development of novel targeted therapeutics. However, this work relies on rigorous, time-intensive, clinic-based laboratory research, making it difficult to translate research paradigms into tools that can be used by clinicians in the community. The broad adoption of smartphone technology provides a promising opportunity to bridge the gap between the mechanisms identified in the laboratory and the clinical interventions targeting them in the community. The goal of the current study is to develop a developmentally appropriate, engaging, novel mobile application called CALM-IT that probes a narrow biologically informed process, inhibitory control. We aim to leverage the rigorous and robust methods traditionally used in laboratory settings to validate this novel mechanism-driven but easily disseminatable tool that can be used by clinicians to probe inhibitory control in the community. The development of CALM-IT has significant implications for the ability to screen for inhibitory control deficits in the community by both clinicians and researchers. By facilitating assessment of inhibitory control outside of the laboratory setting, researchers could have access to larger and more diverse samples. Additionally, in the clinical setting, CALM-IT represents a novel clinical screening measure that could be used to determine personalized courses of treatment based on the presence of inhibitory control deficits.
format	article
author	Elise M Cardinale Reut Naim Simone P Haller Ramaris German Christian Botz-Zapp Jessica Bezek David C Jangraw Melissa A Brotman
author_facet	Elise M Cardinale Reut Naim Simone P Haller Ramaris German Christian Botz-Zapp Jessica Bezek David C Jangraw Melissa A Brotman
author_sort	Elise M Cardinale
title	Rationale and validation of a novel mobile application probing motor inhibition: Proof of concept of CALM-IT.
title_short	Rationale and validation of a novel mobile application probing motor inhibition: Proof of concept of CALM-IT.
title_full	Rationale and validation of a novel mobile application probing motor inhibition: Proof of concept of CALM-IT.
title_fullStr	Rationale and validation of a novel mobile application probing motor inhibition: Proof of concept of CALM-IT.
title_full_unstemmed	Rationale and validation of a novel mobile application probing motor inhibition: Proof of concept of CALM-IT.
title_sort	rationale and validation of a novel mobile application probing motor inhibition: proof of concept of calm-it.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/b8d7dd4a3f2b4ae1ade06f9129b6f1fe
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Rationale and validation of a novel mobile application probing motor inhibition: Proof of concept of CALM-IT.

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