Genetic silencing of olivocerebellar synapses causes dystonia-like behaviour in mice

Dystonia is thought to be driven by impairments in cerebellar signalling. The authors use a mouse genetic approach to silence excitatory transmission in the inferior olive to cerebellum pathway, resulting in dystonia-like signs in the animals which can be alleviated using DBS stimulation of the path...

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Autores principales:	Joshua J. White, Roy V. Sillitoe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b8dadc060130475a8188dfeab7d70fe7
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spelling	oai:doaj.org-article:b8dadc060130475a8188dfeab7d70fe72021-12-02T15:38:36ZGenetic silencing of olivocerebellar synapses causes dystonia-like behaviour in mice10.1038/ncomms149122041-1723https://doaj.org/article/b8dadc060130475a8188dfeab7d70fe72017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms14912https://doaj.org/toc/2041-1723Dystonia is thought to be driven by impairments in cerebellar signalling. The authors use a mouse genetic approach to silence excitatory transmission in the inferior olive to cerebellum pathway, resulting in dystonia-like signs in the animals which can be alleviated using DBS stimulation of the pathway.Joshua J. WhiteRoy V. SillitoeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joshua J. White Roy V. Sillitoe Genetic silencing of olivocerebellar synapses causes dystonia-like behaviour in mice
description	Dystonia is thought to be driven by impairments in cerebellar signalling. The authors use a mouse genetic approach to silence excitatory transmission in the inferior olive to cerebellum pathway, resulting in dystonia-like signs in the animals which can be alleviated using DBS stimulation of the pathway.
format	article
author	Joshua J. White Roy V. Sillitoe
author_facet	Joshua J. White Roy V. Sillitoe
author_sort	Joshua J. White
title	Genetic silencing of olivocerebellar synapses causes dystonia-like behaviour in mice
title_short	Genetic silencing of olivocerebellar synapses causes dystonia-like behaviour in mice
title_full	Genetic silencing of olivocerebellar synapses causes dystonia-like behaviour in mice
title_fullStr	Genetic silencing of olivocerebellar synapses causes dystonia-like behaviour in mice
title_full_unstemmed	Genetic silencing of olivocerebellar synapses causes dystonia-like behaviour in mice
title_sort	genetic silencing of olivocerebellar synapses causes dystonia-like behaviour in mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b8dadc060130475a8188dfeab7d70fe7
work_keys_str_mv	AT joshuajwhite geneticsilencingofolivocerebellarsynapsescausesdystonialikebehaviourinmice AT royvsillitoe geneticsilencingofolivocerebellarsynapsescausesdystonialikebehaviourinmice
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Genetic silencing of olivocerebellar synapses causes dystonia-like behaviour in mice

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