Genetic silencing of olivocerebellar synapses causes dystonia-like behaviour in mice
Dystonia is thought to be driven by impairments in cerebellar signalling. The authors use a mouse genetic approach to silence excitatory transmission in the inferior olive to cerebellum pathway, resulting in dystonia-like signs in the animals which can be alleviated using DBS stimulation of the path...
Guardado en:
Autores principales: | Joshua J. White, Roy V. Sillitoe |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
|
Materias: | |
Acceso en línea: | https://doaj.org/article/b8dadc060130475a8188dfeab7d70fe7 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Spatial reorganization of putaminal dopamine D2-like receptors in cranial and hand dystonia.
por: Kevin J Black, et al.
Publicado: (2014) -
The dystonia patient a guide to practical management /
Publicado: (2009) -
Identifying genetic modifiers of age-associated penetrance in X-linked dystonia-parkinsonism
por: Björn-Hergen Laabs, et al.
Publicado: (2021) -
Internet-based cognitive behavioural therapy as a feasible treatment of adult-onset, focal, isolated, idiopathic cervical dystonia
por: Megan E. Wadon, et al.
Publicado: (2021) -
Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism–dystonia
por: Karin Tuschl, et al.
Publicado: (2016)