Genetic silencing of olivocerebellar synapses causes dystonia-like behaviour in mice

Dystonia is thought to be driven by impairments in cerebellar signalling. The authors use a mouse genetic approach to silence excitatory transmission in the inferior olive to cerebellum pathway, resulting in dystonia-like signs in the animals which can be alleviated using DBS stimulation of the path...

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Autores principales: Joshua J. White, Roy V. Sillitoe
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/b8dadc060130475a8188dfeab7d70fe7
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