CTCF-mediated chromatin looping in EGR2 regulation and SUZ12 recruitment critical for peripheral myelination and repair

CTCF-mediated chromatin looping in EGR2 regulation and SUZ12 recruitment critical for peripheral myelination and repair

Myelination by Schwann cells (SC) in the peripheral nervous system is essential for motor function, and dysregulation of SC myelination can lead to various neuropathies. Here the authors describe a critical role of CCCTC-binding factor (CTCF)-dependent chromatin reorganization in peripheral myelinat...

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Autores principales: Jincheng Wang, Jiajia Wang, Lijun Yang, Chuntao Zhao, Laiman Natalie Wu, Lingli Xu, Feng Zhang, Qinjie Weng, Michael Wegner, Q. Richard Lu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/b8e007163bbb4069ae16b578df1238e7
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spelling oai:doaj.org-article:b8e007163bbb4069ae16b578df1238e72021-12-02T18:01:15ZCTCF-mediated chromatin looping in EGR2 regulation and SUZ12 recruitment critical for peripheral myelination and repair10.1038/s41467-020-17955-22041-1723https://doaj.org/article/b8e007163bbb4069ae16b578df1238e72020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17955-2https://doaj.org/toc/2041-1723Myelination by Schwann cells (SC) in the peripheral nervous system is essential for motor function, and dysregulation of SC myelination can lead to various neuropathies. Here the authors describe a critical role of CCCTC-binding factor (CTCF)-dependent chromatin reorganization in peripheral myelination and myelin regeneration after injury.Jincheng WangJiajia WangLijun YangChuntao ZhaoLaiman Natalie WuLingli XuFeng ZhangQinjie WengMichael WegnerQ. Richard LuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jincheng Wang
Jiajia Wang
Lijun Yang
Chuntao Zhao
Laiman Natalie Wu
Lingli Xu
Feng Zhang
Qinjie Weng
Michael Wegner
Q. Richard Lu
CTCF-mediated chromatin looping in EGR2 regulation and SUZ12 recruitment critical for peripheral myelination and repair
description Myelination by Schwann cells (SC) in the peripheral nervous system is essential for motor function, and dysregulation of SC myelination can lead to various neuropathies. Here the authors describe a critical role of CCCTC-binding factor (CTCF)-dependent chromatin reorganization in peripheral myelination and myelin regeneration after injury.
format article
author Jincheng Wang
Jiajia Wang
Lijun Yang
Chuntao Zhao
Laiman Natalie Wu
Lingli Xu
Feng Zhang
Qinjie Weng
Michael Wegner
Q. Richard Lu
author_facet Jincheng Wang
Jiajia Wang
Lijun Yang
Chuntao Zhao
Laiman Natalie Wu
Lingli Xu
Feng Zhang
Qinjie Weng
Michael Wegner
Q. Richard Lu
author_sort Jincheng Wang
title CTCF-mediated chromatin looping in EGR2 regulation and SUZ12 recruitment critical for peripheral myelination and repair
title_short CTCF-mediated chromatin looping in EGR2 regulation and SUZ12 recruitment critical for peripheral myelination and repair
title_full CTCF-mediated chromatin looping in EGR2 regulation and SUZ12 recruitment critical for peripheral myelination and repair
title_fullStr CTCF-mediated chromatin looping in EGR2 regulation and SUZ12 recruitment critical for peripheral myelination and repair
title_full_unstemmed CTCF-mediated chromatin looping in EGR2 regulation and SUZ12 recruitment critical for peripheral myelination and repair
title_sort ctcf-mediated chromatin looping in egr2 regulation and suz12 recruitment critical for peripheral myelination and repair
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/b8e007163bbb4069ae16b578df1238e7
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AT jiajiawang ctcfmediatedchromatinloopinginegr2regulationandsuz12recruitmentcriticalforperipheralmyelinationandrepair
AT lijunyang ctcfmediatedchromatinloopinginegr2regulationandsuz12recruitmentcriticalforperipheralmyelinationandrepair
AT chuntaozhao ctcfmediatedchromatinloopinginegr2regulationandsuz12recruitmentcriticalforperipheralmyelinationandrepair
AT laimannataliewu ctcfmediatedchromatinloopinginegr2regulationandsuz12recruitmentcriticalforperipheralmyelinationandrepair
AT linglixu ctcfmediatedchromatinloopinginegr2regulationandsuz12recruitmentcriticalforperipheralmyelinationandrepair
AT fengzhang ctcfmediatedchromatinloopinginegr2regulationandsuz12recruitmentcriticalforperipheralmyelinationandrepair
AT qinjieweng ctcfmediatedchromatinloopinginegr2regulationandsuz12recruitmentcriticalforperipheralmyelinationandrepair
AT michaelwegner ctcfmediatedchromatinloopinginegr2regulationandsuz12recruitmentcriticalforperipheralmyelinationandrepair
AT qrichardlu ctcfmediatedchromatinloopinginegr2regulationandsuz12recruitmentcriticalforperipheralmyelinationandrepair
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