Characterization of Mechanically Matched Hydrogel Coatings to Improve the Biocompatibility of Neural Implants

Abstract Glial scar is a significant barrier to neural implant function. Micromotion between the implant and tissue is suspected to be a key driver of glial scar formation around neural implants. This study explores the ability of soft hydrogel coatings to modulate glial scar formation by reducing l...

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Autores principales:	Kevin C. Spencer, Jay C. Sy, Khalil B. Ramadi, Ann M. Graybiel, Robert Langer, Michael J. Cima
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b8e206c5bb394f56a0dc7f74f7e112c5
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spelling	oai:doaj.org-article:b8e206c5bb394f56a0dc7f74f7e112c52021-12-02T16:07:57ZCharacterization of Mechanically Matched Hydrogel Coatings to Improve the Biocompatibility of Neural Implants10.1038/s41598-017-02107-22045-2322https://doaj.org/article/b8e206c5bb394f56a0dc7f74f7e112c52017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02107-2https://doaj.org/toc/2045-2322Abstract Glial scar is a significant barrier to neural implant function. Micromotion between the implant and tissue is suspected to be a key driver of glial scar formation around neural implants. This study explores the ability of soft hydrogel coatings to modulate glial scar formation by reducing local strain. PEG hydrogels with controllable thickness and elastic moduli were formed on the surface of neural probes. These coatings significantly reduced the local strain resulting from micromotion around the implants. Coated implants were found to significantly reduce scarring in vivo, compared to hard implants of identical diameter. Increasing implant diameter was found to significantly increase scarring for glass implants, as well as increase local BBB permeability, increase macrophage activation, and decrease the local neural density. These results highlight the tradeoff in mechanical benefit with the size effects from increasing the overall diameter following the addition of a hydrogel coating. This study emphasizes the importance of both mechanical and geometric factors of neural implants on chronic timescales.Kevin C. SpencerJay C. SyKhalil B. RamadiAnn M. GraybielRobert LangerMichael J. CimaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kevin C. Spencer Jay C. Sy Khalil B. Ramadi Ann M. Graybiel Robert Langer Michael J. Cima Characterization of Mechanically Matched Hydrogel Coatings to Improve the Biocompatibility of Neural Implants
description	Abstract Glial scar is a significant barrier to neural implant function. Micromotion between the implant and tissue is suspected to be a key driver of glial scar formation around neural implants. This study explores the ability of soft hydrogel coatings to modulate glial scar formation by reducing local strain. PEG hydrogels with controllable thickness and elastic moduli were formed on the surface of neural probes. These coatings significantly reduced the local strain resulting from micromotion around the implants. Coated implants were found to significantly reduce scarring in vivo, compared to hard implants of identical diameter. Increasing implant diameter was found to significantly increase scarring for glass implants, as well as increase local BBB permeability, increase macrophage activation, and decrease the local neural density. These results highlight the tradeoff in mechanical benefit with the size effects from increasing the overall diameter following the addition of a hydrogel coating. This study emphasizes the importance of both mechanical and geometric factors of neural implants on chronic timescales.
format	article
author	Kevin C. Spencer Jay C. Sy Khalil B. Ramadi Ann M. Graybiel Robert Langer Michael J. Cima
author_facet	Kevin C. Spencer Jay C. Sy Khalil B. Ramadi Ann M. Graybiel Robert Langer Michael J. Cima
author_sort	Kevin C. Spencer
title	Characterization of Mechanically Matched Hydrogel Coatings to Improve the Biocompatibility of Neural Implants
title_short	Characterization of Mechanically Matched Hydrogel Coatings to Improve the Biocompatibility of Neural Implants
title_full	Characterization of Mechanically Matched Hydrogel Coatings to Improve the Biocompatibility of Neural Implants
title_fullStr	Characterization of Mechanically Matched Hydrogel Coatings to Improve the Biocompatibility of Neural Implants
title_full_unstemmed	Characterization of Mechanically Matched Hydrogel Coatings to Improve the Biocompatibility of Neural Implants
title_sort	characterization of mechanically matched hydrogel coatings to improve the biocompatibility of neural implants
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b8e206c5bb394f56a0dc7f74f7e112c5
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Characterization of Mechanically Matched Hydrogel Coatings to Improve the Biocompatibility of Neural Implants

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