Profiling serum antibodies with a pan allergen phage library identifies key wheat allergy epitopes

A diverse array of antigens can trigger allergic reactions. Here the authors present the ‘AllerScan’ programmable phage display library, which is an efficient and unbiased approach for profiling anti-allergen antibody reactivities at cohort scale, with which a key wheat epitope is found to distingui...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Daniel R. Monaco, Brandon M. Sie, Thomas R. Nirschl, Audrey C. Knight, Hugh A. Sampson, Anna Nowak-Wegrzyn, Robert A. Wood, Robert G. Hamilton, Pamela A. Frischmeyer-Guerrerio, H. Benjamin Larman
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Q
Acceso en línea:https://doaj.org/article/b8e61b941a1b437c95176c991f1acd7e
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
Descripción
Sumario:A diverse array of antigens can trigger allergic reactions. Here the authors present the ‘AllerScan’ programmable phage display library, which is an efficient and unbiased approach for profiling anti-allergen antibody reactivities at cohort scale, with which a key wheat epitope is found to distinguish between wheat allergy and tolerance.