The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks

The BLM helicase interacts with the topoisomerase TOP3A and RMI1 to form the BTR complex. Here, the authors reveal that this complex contains multiple binding sites for the single-stranded DNA-binding complex RPA, and that RPA-binding stimulates BLM recruitment to stalled replication forks to promot...

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Autores principales:	Ann-Marie K. Shorrocks, Samuel E. Jones, Kaima Tsukada, Carl A. Morrow, Zoulikha Belblidia, Johanna Shen, Iolanda Vendrell, Roman Fischer, Benedikt M. Kessler, Andrew N. Blackford
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b8e899d3fab949ef9615c88f13f058e9
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spelling	oai:doaj.org-article:b8e899d3fab949ef9615c88f13f058e92021-12-02T10:47:59ZThe Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks10.1038/s41467-020-20818-52041-1723https://doaj.org/article/b8e899d3fab949ef9615c88f13f058e92021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20818-5https://doaj.org/toc/2041-1723The BLM helicase interacts with the topoisomerase TOP3A and RMI1 to form the BTR complex. Here, the authors reveal that this complex contains multiple binding sites for the single-stranded DNA-binding complex RPA, and that RPA-binding stimulates BLM recruitment to stalled replication forks to promote their restart after replication stress.Ann-Marie K. ShorrocksSamuel E. JonesKaima TsukadaCarl A. MorrowZoulikha BelblidiaJohanna ShenIolanda VendrellRoman FischerBenedikt M. KesslerAndrew N. BlackfordNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ann-Marie K. Shorrocks Samuel E. Jones Kaima Tsukada Carl A. Morrow Zoulikha Belblidia Johanna Shen Iolanda Vendrell Roman Fischer Benedikt M. Kessler Andrew N. Blackford The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks
description	The BLM helicase interacts with the topoisomerase TOP3A and RMI1 to form the BTR complex. Here, the authors reveal that this complex contains multiple binding sites for the single-stranded DNA-binding complex RPA, and that RPA-binding stimulates BLM recruitment to stalled replication forks to promote their restart after replication stress.
format	article
author	Ann-Marie K. Shorrocks Samuel E. Jones Kaima Tsukada Carl A. Morrow Zoulikha Belblidia Johanna Shen Iolanda Vendrell Roman Fischer Benedikt M. Kessler Andrew N. Blackford
author_facet	Ann-Marie K. Shorrocks Samuel E. Jones Kaima Tsukada Carl A. Morrow Zoulikha Belblidia Johanna Shen Iolanda Vendrell Roman Fischer Benedikt M. Kessler Andrew N. Blackford
author_sort	Ann-Marie K. Shorrocks
title	The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks
title_short	The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks
title_full	The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks
title_fullStr	The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks
title_full_unstemmed	The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks
title_sort	bloom syndrome complex senses rpa-coated single-stranded dna to restart stalled replication forks
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b8e899d3fab949ef9615c88f13f058e9
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The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks

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