Network pharmacology combined with metabolomics to investigate the anti-hyperlipidemia mechanism of a novel combination

This study aimed to investigate the hypolipidemic effect and mechanism of aqueous extract of Lindera aggregate leaves and Aloe vera (AqLL-A) in mice. Chemical profile of AqLL-A, serum/hepatic lipid profiles, and fecal TG were measured. The major components of AqLL-A related to hyperlipidemia, querci...

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Autores principales:	Furong Wang, Juan Wang, Hongdie Cai, Lixia Yuan, Chonglu Sun, Xin Peng, Weiwei Yan, Jiale Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Lindera aggregate leave Aloe vera Hyperlipidemia Network pharmacology Metabolomics Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/b8e8bf618c7e4ce5874764a6a15df0e6
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spelling	oai:doaj.org-article:b8e8bf618c7e4ce5874764a6a15df0e62021-11-12T04:28:57ZNetwork pharmacology combined with metabolomics to investigate the anti-hyperlipidemia mechanism of a novel combination1756-464610.1016/j.jff.2021.104848https://doaj.org/article/b8e8bf618c7e4ce5874764a6a15df0e62021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1756464621004977https://doaj.org/toc/1756-4646This study aimed to investigate the hypolipidemic effect and mechanism of aqueous extract of Lindera aggregate leaves and Aloe vera (AqLL-A) in mice. Chemical profile of AqLL-A, serum/hepatic lipid profiles, and fecal TG were measured. The major components of AqLL-A related to hyperlipidemia, quercitrin and aloin were confirmed by HPLC. AqLL-A reduced serum/hepatic lipids, while elevated serum HDL, APOA1, fecal TG levels in hyperlipidemia mice. Furthermore, 20 potential biomarkers were detected by UPLC-QTOF/MS, and all of them were approached to a normal-like level after treatment of AqLL-A. Network pharmacology combined with metabolomics elucidate the related pathways involved in hyperlipidemia. The experimental validation indicated the differential expressions of CYP7A1, ACAT and HMGCR contribute to the hypolipidemic mechanism of AqLL-A. These results suggested that AqLL-A alleviated hyperlipidemia effectively, it might play synergistic therapeutic efficacies through regulating metabolic profiles and related signaling pathway.Furong WangJuan WangHongdie CaiLixia YuanChonglu SunXin PengWeiwei YanJiale ZhangElsevierarticleLindera aggregate leaveAloe veraHyperlipidemiaNetwork pharmacologyMetabolomicsNutrition. Foods and food supplyTX341-641ENJournal of Functional Foods, Vol 87, Iss , Pp 104848- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Lindera aggregate leave Aloe vera Hyperlipidemia Network pharmacology Metabolomics Nutrition. Foods and food supply TX341-641
spellingShingle	Lindera aggregate leave Aloe vera Hyperlipidemia Network pharmacology Metabolomics Nutrition. Foods and food supply TX341-641 Furong Wang Juan Wang Hongdie Cai Lixia Yuan Chonglu Sun Xin Peng Weiwei Yan Jiale Zhang Network pharmacology combined with metabolomics to investigate the anti-hyperlipidemia mechanism of a novel combination
description	This study aimed to investigate the hypolipidemic effect and mechanism of aqueous extract of Lindera aggregate leaves and Aloe vera (AqLL-A) in mice. Chemical profile of AqLL-A, serum/hepatic lipid profiles, and fecal TG were measured. The major components of AqLL-A related to hyperlipidemia, quercitrin and aloin were confirmed by HPLC. AqLL-A reduced serum/hepatic lipids, while elevated serum HDL, APOA1, fecal TG levels in hyperlipidemia mice. Furthermore, 20 potential biomarkers were detected by UPLC-QTOF/MS, and all of them were approached to a normal-like level after treatment of AqLL-A. Network pharmacology combined with metabolomics elucidate the related pathways involved in hyperlipidemia. The experimental validation indicated the differential expressions of CYP7A1, ACAT and HMGCR contribute to the hypolipidemic mechanism of AqLL-A. These results suggested that AqLL-A alleviated hyperlipidemia effectively, it might play synergistic therapeutic efficacies through regulating metabolic profiles and related signaling pathway.
format	article
author	Furong Wang Juan Wang Hongdie Cai Lixia Yuan Chonglu Sun Xin Peng Weiwei Yan Jiale Zhang
author_facet	Furong Wang Juan Wang Hongdie Cai Lixia Yuan Chonglu Sun Xin Peng Weiwei Yan Jiale Zhang
author_sort	Furong Wang
title	Network pharmacology combined with metabolomics to investigate the anti-hyperlipidemia mechanism of a novel combination
title_short	Network pharmacology combined with metabolomics to investigate the anti-hyperlipidemia mechanism of a novel combination
title_full	Network pharmacology combined with metabolomics to investigate the anti-hyperlipidemia mechanism of a novel combination
title_fullStr	Network pharmacology combined with metabolomics to investigate the anti-hyperlipidemia mechanism of a novel combination
title_full_unstemmed	Network pharmacology combined with metabolomics to investigate the anti-hyperlipidemia mechanism of a novel combination
title_sort	network pharmacology combined with metabolomics to investigate the anti-hyperlipidemia mechanism of a novel combination
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/b8e8bf618c7e4ce5874764a6a15df0e6
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Network pharmacology combined with metabolomics to investigate the anti-hyperlipidemia mechanism of a novel combination

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